ID A0A0R4J0U3_MOUSE Unreviewed; 1257 AA.
AC A0A0R4J0U3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Period circadian protein homolog 2 {ECO:0000256|ARBA:ARBA00039684};
DE AltName: Full=Circadian clock protein PERIOD 2 {ECO:0000256|ARBA:ARBA00042893};
GN Name=Per2 {ECO:0000313|Ensembl:ENSMUSP00000066620.9};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000066620.9, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000066620.9, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000066620.9,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000066620.9}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000066620.9};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_035196.2; NM_011066.3.
DR AlphaFoldDB; A0A0R4J0U3; -.
DR SMR; A0A0R4J0U3; -.
DR ProteomicsDB; 359489; -.
DR Antibodypedia; 34500; 453 antibodies from 34 providers.
DR DNASU; 18627; -.
DR Ensembl; ENSMUST00000069620.10; ENSMUSP00000066620.9; ENSMUSG00000055866.10.
DR GeneID; 18627; -.
DR KEGG; mmu:18627; -.
DR CTD; 8864; -.
DR MGI; MGI:1195265; Per2.
DR VEuPathDB; HostDB:ENSMUSG00000055866; -.
DR GeneTree; ENSGT00940000156342; -.
DR OMA; ENCSMGR; -.
DR OrthoDB; 2971905at2759; -.
DR PhylomeDB; A0A0R4J0U3; -.
DR BioGRID-ORCS; 18627; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Per2; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000055866; Expressed in caudate-putamen and 238 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR048814; Per1-3_PAS-A.
DR InterPro; IPR022728; Period_circadian-like_C.
DR PANTHER; PTHR11269; PERIOD CIRCADIAN PROTEIN; 1.
DR PANTHER; PTHR11269:SF9; PERIOD CIRCADIAN PROTEIN HOMOLOG 2; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF21353; Per3-like_PAS-A; 1.
DR Pfam; PF12114; Period_C; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50112; PAS; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 344..387
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1257 AA; 135899 MW; 57D6D3599BAB57D2 CRC64;
MNGYVDFSPS PTSPTKEPGA PQPTQAVLQE DVDMSSGSSG NENCSTGRDS QGSDCDDNGK
ELRMLVESSN THPSPDDAFR LMMTEAEHNP STSGCSSEQS AKADAHKELI RTLKELKVHL
PADKKAKGKA STLATLKYAL RSVKQVKANE EYYQLLMSSE SQPCSVDVPS YSMEQVEGIT
SEYIVKNADM FAVAVSLVSG KILYISNQVA SIFHCKKDAF SDAKFVEFLA PHDVSVFHSY
TTPYKLPPWS VCSGLDSFTQ ECMEEKSFFC RVSVGKHHEN EIRYQPFRMT PYLVKVQEQQ
GAESQLCCLL LAERVHSGYE APRIPPEKRI FTTTHTPNCL FQAVDERAVP LLGYLPQDLI
ETPVLVQLHP SDRPLMLAIH KKILQAGGQP FDYSPIRFRT RNGEYITLDT SWSSFINPWS
RKISFIIGRH KVRVGPLNED VFAASPCPEE KTPHPSVQEL TEQIHRLLMQ PVPHSGSSGY
GSLGSNGSHE HLMSQTSSSD SNGQEESHRR RSGIFKTSGK IQTKSHVSHE SGGQKEASVA
EMQSSPPAQV KAVTTIERDS SGASLPKASF PEELAYKNQP PCSYQQISCL DSVIRYLESC
SEAATLKRKC EFPANIPSRK ATVSPGLHSG EAARPSKVTS HTEVSAHLSS LTLPGKAESV
VSLTSQCSYS STIVHVGDKK PQPELETVED MASGPESLDG AAGGLSQEKG PLQKLGLTKE
VLAAHTQREE QGFLQRFREV SRLSALQAHC QNYLQERSRA QASDRGLRNT SGLESSWKKT
GKNRKLKSKR VKTRDSSEST GSGGPVSHRP PLMGLNATAW SPSDTSQSSC PSAPFPTAVP
AYPLPVFQAP GIVSTPGTVV APPAATHTGF TMPVVPMGTQ PEFAVQPLPF AAPLAPVMAF
MLPSYPFPPA TPNLPQAFLP SQPHFPAHPT LASEITPASQ AEFPSRTSTL RQPCACPVTP
PAGTVALGRA SPPLFQSRGS SPLQLNLLQL EEAPEGSTGA AGTLGTTGTA ASGLDCTSGT
SRDRQPKAPP TCNEPSDTQN SDAISTSSDL LNLLLGEDLC SATGSALSRS GASATSDSLG
SSSLGFGTSQ SGAGSSDTSH TSKYFGSIDS SENNHKAKMI PDTEESEQFI KYVLQDPIWL
LMANTDDSIM MTYQLPSRDL QAVLKEDQEK LKLLQRSQPR FTEGQRRELR EVHPWVHTGG
LPTAIDVTGC VYCESEEKGN ICLPYEEDSP SPGLCDTSEA KEEEGEQLTG PRIEAQT
//
