ID A0A0R4J156_MOUSE Unreviewed; 300 AA.
AC A0A0R4J156;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Renalase {ECO:0000313|Ensembl:ENSMUSP00000093825};
GN Name=Rnls {ECO:0000313|Ensembl:ENSMUSP00000093825,
GN ECO:0000313|MGI:MGI:1915045};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000093825, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000093825, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000093825,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000093825}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000093825};
RG Ensembl;
RL Submitted (MAR-2016) to UniProtKB.
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DR EMBL; AC117183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC125381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC160088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001161290.1; NM_001167818.1.
DR AlphaFoldDB; A0A0R4J156; -.
DR SMR; A0A0R4J156; -.
DR ProteomicsDB; 359560; -.
DR Antibodypedia; 30183; 320 antibodies from 32 providers.
DR Ensembl; ENSMUST00000096114; ENSMUSP00000093825; ENSMUSG00000071573.
DR AGR; MGI:1915045; -.
DR MGI; MGI:1915045; Rnls.
DR GeneTree; ENSGT00390000016052; -.
DR PhylomeDB; A0A0R4J156; -.
DR BioGRID-ORCS; 67795; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Rnls; mouse.
DR Proteomes; UP000000589; Chromosome 19.
DR Bgee; ENSMUSG00000071573; Expressed in spermatocyte and 139 other cell types or tissues.
DR ExpressionAtlas; A0A0R4J156; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0051379; F:epinephrine binding; IEA:Ensembl.
DR GO; GO:0097621; F:monoamine oxidase activity; IEA:Ensembl.
DR GO; GO:0070404; F:NADH binding; IEA:Ensembl.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:Ensembl.
DR GO; GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0010459; P:negative regulation of heart rate; IEA:Ensembl.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR040174; RNLS.
DR PANTHER; PTHR23357:SF1; RENALASE; 1.
DR PANTHER; PTHR23357; UNCHARACTERIZED; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 1: Evidence at protein level;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Proteomics identification {ECO:0007829|MaxQB:A0A0R4J156,
KW ECO:0007829|ProteomicsDB:A0A0R4J156};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 63..291
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 300 AA; 33286 MW; 341B064A041B3262 CRC64;
MITASSPHNP RCTADLGAQY ITCSPHYVKE HQNFYEELLA HGILKPLTSP IEGMKGKEGD
CNFVAPQGFS SVIKYYLKKS GAEVSLKHCV TQIHLKDNKW EVSTDTGSAE QFDLVILTMP
APQILELQGD IVNLISERQR EQLKSVSYSS RYALGLFYEV GMKIGVPWSC RYLSSHPCIC
FISIDNKKRN IESSECGPSV VIQTTVPFGV QHLEASEADV QKLMIQQLET ILPGLPQPVA
TICHKWTYSQ VTSSVSDRPG QMTLHLKPFL VCGGDGFTHS NFNGCISSAL SVMKVLKRYI
//
