ID A0A0R4J1R5_MOUSE Unreviewed; 219 AA.
AC A0A0R4J1R5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Interferon activated gene 214 {ECO:0000313|Ensembl:ENSMUSP00000115105.2};
GN Name=Ifi214 {ECO:0000313|Ensembl:ENSMUSP00000115105.2,
GN ECO:0000313|MGI:MGI:3584522};
GN Synonyms=BC094916 {ECO:0000313|MGI:MGI:3584522};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115105.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000115105.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115105.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000115105.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115105.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the HIN-200 family.
CC {ECO:0000256|ARBA:ARBA00008647}.
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DR RefSeq; NP_001019892.2; NM_001024721.2.
DR AlphaFoldDB; A0A0R4J1R5; -.
DR SMR; A0A0R4J1R5; -.
DR STRING; 10090.ENSMUSP00000115105; -.
DR jPOST; A0A0R4J1R5; -.
DR PaxDb; 10090-ENSMUSP00000115105; -.
DR ProteomicsDB; 373897; -.
DR Ensembl; ENSMUST00000139092.8; ENSMUSP00000115105.2; ENSMUSG00000070501.15.
DR GeneID; 545384; -.
DR KEGG; mmu:545384; -.
DR AGR; MGI:3584522; -.
DR CTD; 545384; -.
DR MGI; MGI:3584522; Ifi214.
DR VEuPathDB; HostDB:ENSMUSG00000070501; -.
DR eggNOG; ENOG502QTQS; Eukaryota.
DR GeneTree; ENSGT00390000013296; -.
DR OrthoDB; 5360740at2759; -.
DR BioGRID-ORCS; 545384; 2 hits in 75 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000070501; Expressed in spleen and 12 other cell types or tissues.
DR ExpressionAtlas; A0A0R4J1R5; baseline and differential.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR CDD; cd08305; Pyrin; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR PANTHER; PTHR12200:SF24; INTERFERON-ACTIVABLE PROTEIN 203-RELATED; 1.
DR PANTHER; PTHR12200; INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR PROSITE; PS50824; DAPIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..87
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT REGION 82..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 219 AA; 23990 MW; 0AFD211AD5397383 CRC64;
MVNEYKRIVL LTGLMGINDH DFRMVKSLLS KELKLNKMQD EYDRVKIADL MEDKFPKDAG
VVQLIKLYKQ IPGLGDIANK LKNEKAKAKR KGKGKRKTAA KRQRQEEPST SQPMSTTNED
AEPESGRSTP DTQVAQLSLP TASRRNQAIQ ISPTIASSSG QTSSRSSETL QSIIQSPETP
TRSSSRILDP PVSPGTAYSS AQALGVLLAT PAKVIKARN
//
