ID A0A0R4J268_MOUSE Unreviewed; 970 AA.
AC A0A0R4J268;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Oncostatin M receptor {ECO:0000313|Ensembl:ENSMUSP00000135204.2};
GN Name=Osmr {ECO:0000313|Ensembl:ENSMUSP00000135204.2,
GN ECO:0000313|MGI:MGI:1330819};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000135204.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000135204.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135204.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000135204.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135204.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR RefSeq; NP_001297398.1; NM_001310469.1.
DR AlphaFoldDB; A0A0R4J268; -.
DR SMR; A0A0R4J268; -.
DR ProteomicsDB; 314465; -.
DR Antibodypedia; 2731; 475 antibodies from 35 providers.
DR DNASU; 18414; -.
DR Ensembl; ENSMUST00000176826.2; ENSMUSP00000135204.2; ENSMUSG00000022146.13.
DR GeneID; 18414; -.
DR AGR; MGI:1330819; -.
DR CTD; 9180; -.
DR MGI; MGI:1330819; Osmr.
DR VEuPathDB; HostDB:ENSMUSG00000022146; -.
DR GeneTree; ENSGT00940000160851; -.
DR OrthoDB; 5347052at2759; -.
DR BioGRID-ORCS; 18414; 4 hits in 80 CRISPR screens.
DR ChiTaRS; Osmr; mouse.
DR Proteomes; UP000000589; Chromosome 15.
DR Bgee; ENSMUSG00000022146; Expressed in pigmented layer of retina and 195 other cell types or tissues.
DR ExpressionAtlas; A0A0R4J268; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048497; LIF-R-like_Ig-like.
DR InterPro; IPR040817; LIFR_D2.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF95; ONCOSTATIN-M-SPECIFIC RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF21177; LIF-R_Ig-like; 1.
DR Pfam; PF17971; LIFR_D2; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:A0A0R4J268,
KW ECO:0007829|PeptideAtlas:A0A0R4J268};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..970
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006452027"
FT TRANSMEM 736..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 332..425
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 523..619
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 621..732
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 948..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 110070 MW; E3A07D41754FA847 CRC64;
MAFSVVLHPA FLLAVLSLRA SRSEVLEEPL PLTPEIHKVS FQLKLQEVNL EWTVPALTHE
ELNMIFQIEI SRLNISNTIW VENYSTTVKR EEAVRWNWTS DIPLECVKHF IRIRALVDDT
KSLPQSSWGN WSSWKEVNAK VSVEPDKSLI FPKDKVLEEG SNVTICLMYG QNVYNVSCKL
QDEPIHGEQL DSHVSLLKLN NVVFLSDTGT NINCQATKGP KRIFGTVLFV SKVLEEPKNV
SCETRDFKTL DCSWEPGVDT TLTWRKQRFQ NYTLCESFSK RCEVSNYRNS YTWQITEGSQ
EMYNFTLTAE NQLRKRSVNI NFNLTHRVHP KAPQDVTLKI IGATKANMTW KVHSHGNNYT
LLCQVKLQYG EVIHEHNVSV HMSANYLFSD LDPDTKYKAF VRCASANHFW KWSDWTQKEF
STPETAPSQA LDVWRQVWSE NGRRIVTLFW KPLLKSQANG KIISYNIVVE NEAKPTESEH
YCVWAPALST NLSLDLQPYK IRITANNSMG ASPESLMVLS NDSGHEVKEK TIKGIKDAFN
ISWEPVSGDT MGYVVDWCAH SQDQRCDLQW KNLGPNTTST TITSDDFKPG VRYNFRIFER
SVEHKARLVE KQRGYTQELA PLVNPKVEIP YSTPNSFVLR WPDYDSDFQA GFIKGYLVYV
KSKEMQCNQP WERTLLPDNS VLCKYDINGS ETKTLTVENL QPESLYEFFV TPYTSAGPGP
NETFTKVTTP DARSHMLLQI ILPMTLCVLL SIIVCYWKSQ WVKEKCYPDI PNPYKSSILS
LIKSKKNPHL IMNVKDCIPD VLEVINKAEG SKTQCVGSGK LHIEDVPTKP PIVPTEKDSS
GPVPCIFFEN FTYDQSAFDS GSHGLIPGPL KDTAHQLGLL APPNKFQNVL KNDYMKPLVE
SPTEETSLIY VSQLASPMCG DKDTLATEPP VPVHGSEYKR QMVVPGSLAS PSLKEDNSLT
STVLLGQGEQ
//
