ID A0A0S0WIG6_DROME Unreviewed; 991 AA.
AC A0A0S0WIG6;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Ecdysone-induced protein 75B, isoform G {ECO:0000313|EMBL:ALI30484.1};
GN Name=Eip75B {ECO:0000313|EMBL:ALI30484.1,
GN ECO:0000313|FlyBase:FBgn0000568};
GN Synonyms=57B {ECO:0000313|EMBL:ALI30484.1}, 75B
GN {ECO:0000313|EMBL:ALI30484.1}, anon-WO0172774.31
GN {ECO:0000313|EMBL:ALI30484.1}, anon-WO0172774.32
GN {ECO:0000313|EMBL:ALI30484.1}, BcDNA:GM02640
GN {ECO:0000313|EMBL:ALI30484.1}, dE75 {ECO:0000313|EMBL:ALI30484.1},
GN DmE75 {ECO:0000313|EMBL:ALI30484.1}, DmE75A
GN {ECO:0000313|EMBL:ALI30484.1}, DmE75B {ECO:0000313|EMBL:ALI30484.1},
GN Dmel\CG8127 {ECO:0000313|EMBL:ALI30484.1}, E75
GN {ECO:0000313|EMBL:ALI30484.1}, E75-C {ECO:0000313|EMBL:ALI30484.1},
GN E75A {ECO:0000313|EMBL:ALI30484.1}, E75B
GN {ECO:0000313|EMBL:ALI30484.1}, E75C {ECO:0000313|EMBL:ALI30484.1},
GN EiP75 {ECO:0000313|EMBL:ALI30484.1}, Eip75
GN {ECO:0000313|EMBL:ALI30484.1}, Eip75 A {ECO:0000313|EMBL:ALI30484.1},
GN Eip75A {ECO:0000313|EMBL:ALI30484.1}, eip75a
GN {ECO:0000313|EMBL:ALI30484.1}, eip75B {ECO:0000313|EMBL:ALI30484.1},
GN EP1121b {ECO:0000313|EMBL:ALI30484.1}, l(3)07041
GN {ECO:0000313|EMBL:ALI30484.1}, l(3)j11A6
GN {ECO:0000313|EMBL:ALI30484.1}, l(3)j12E8
GN {ECO:0000313|EMBL:ALI30484.1}, l(3)j3A6 {ECO:0000313|EMBL:ALI30484.1},
GN l(3)j5E1 {ECO:0000313|EMBL:ALI30484.1}, l(3)neo25
GN {ECO:0000313|EMBL:ALI30484.1}, Mgn00274 {ECO:0000313|EMBL:ALI30484.1},
GN NR1D3 {ECO:0000313|EMBL:ALI30484.1}, Rev-Erb
GN {ECO:0000313|EMBL:ALI30484.1}, REV-ERB&agr
GN {ECO:0000313|EMBL:ALI30484.1};
GN ORFNames=CG8127 {ECO:0000313|EMBL:ALI30484.1,
GN ECO:0000313|FlyBase:FBgn0000568}, Dmel_CG8127
GN {ECO:0000313|EMBL:ALI30484.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ALI30484.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:ALI30484.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:ALI30484.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:ALI30484.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:ALI30484.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:ALI30484.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR EMBL; AE014296; ALI30484.1; -; Genomic_DNA.
DR RefSeq; NP_001303380.1; NM_001316451.1.
DR AlphaFoldDB; A0A0S0WIG6; -.
DR SMR; A0A0S0WIG6; -.
DR DNASU; 39999; -.
DR EnsemblMetazoa; FBtr0347013; FBpp0312446; FBgn0000568.
DR GeneID; 39999; -.
DR AGR; FB:FBgn0000568; -.
DR CTD; 39999; -.
DR FlyBase; FBgn0000568; Eip75B.
DR VEuPathDB; VectorBase:FBgn0000568; -.
DR OrthoDB; 3475284at2759; -.
DR BioGRID-ORCS; 39999; 1 hit in 3 CRISPR screens.
DR ChiTaRS; Eip75B; fly.
DR GenomeRNAi; 39999; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0000568; Expressed in brain and 27 other cell types or tissues.
DR ExpressionAtlas; A0A0S0WIG6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd07166; NR_DBD_REV_ERB; 1.
DR CDD; cd06940; NR_LBD_REV_ERB; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001728; ThyrH_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082:SF508; ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B; 1.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00546; THYROIDHORMR.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 34..110
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 144..392
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 416..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 991 AA; 106223 MW; A4F945E12AC50AD0 CRC64;
MTVGSREDLF AQAKHIDDTE RLIGRVLAEF DGTTVLCRVC GDKASGFHYG VHSCEGCKGF
FRRSIQQKIQ YRPCTKNQQC SILRINRNRC QYCRLKKCIA VGMSRDAVRF GRVPKREKAR
ILAAMQQSTQ NRGQQRALAT ELDDQPRLLA AVLRAHLETC EFTKEKVSAM RQRARDCPSY
SMPTLLACPL NPAPELQSEQ EFSQRFAHVI RGVIDFAGMI PGFQLLTQDD KFTLLKAGLF
DALFVRLICM FDSSINSIIC LNGQVMRRDA IQNGANARFL VDSTFNFAER MNSMNLTDAE
IGLFCAIVLI TPDRPGLRNL ELIEKMYSRL KGCLQYIVAQ NRPDQPEFLA KLLETMPDLR
TLSTLHTEKL VVFRTEHKEL LRQQMWSMED GNNSDGQQNK SPSGSWADAM DVEAAKSPLG
SVSSTESADL DYGSPSSSQP QGVSLPSPPQ QQPSALASSA PLLAATLSGG CPLRNRANSG
SSGDSGAAEM DIVGSHAHLT QNGLTITPIV RHQQQQQQQQ QIGILNNAHS RNLNGGHAMC
QQQQQHPQLH HHLTAGAARY RKLDSPTDSG IESGNEKNEC KAVSSGGSSS CSSPRSSVDD
ALDCSDAAAN HNQVVQHPQL SVVSVSPVRS PQPSTSSHLK RQIVEDMPVL KRVLQAPPLY
DTNSLMDEAY KPHKKFRALR HREFETAEAD ASSSTSGSNS LSAGSPRQSP VPNSVATPPP
SAASAAAGNP AQSQLHMHLT RSSPKASMAS SHSVLAKSLM AEPRMTPEQM KRSDIIQNYL
KRENSTAASS TTNGVGNRSP SSSSTPPPSA VQNQQRWGSS SVITTTCQQR QQSVSPHSNG
SSSSSSSSSS SSSSSSSTSS NCSSSSASSC QYFQSPHSTS NGTSAPASSS SGSNSATPLL
ELQVDIADSA QPLNLSKKSP TPPPSKLHAL VAAANAVQRY PTLSADVTVT ASNGGPPSAA
ASPAPSSSPP ASVGSPNPGL SAAVHKVMLE A
//
