ID A0A0S1TPJ9_9BETA Unreviewed; 957 AA.
AC A0A0S1TPJ9;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Helicase subunit {ECO:0000313|EMBL:ALM26025.1};
GN Name=U77 {ECO:0000313|EMBL:ALM26025.1};
OS Elephant endotheliotropic herpesvirus 4.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Proboscivirus.
OX NCBI_TaxID=548914 {ECO:0000313|EMBL:ALM26025.1, ECO:0000313|Proteomes:UP000161618};
RN [1] {ECO:0000313|Proteomes:UP000161618}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=19112123; DOI=10.1354/vp.46-1-97;
RA Garner M.M., Helmick K., Ochsenreiter J., Richman L.K., Latimer E.,
RA Wise A.G., Maes R.K., Kiupel M., Nordhausen R.W., Zong J.C., Hayward G.S.;
RT "Clinico-pathologic features of fatal disease attributed to new variants of
RT endotheliotropic herpesviruses in two Asian elephants (Elephas maximus).";
RL Vet. Pathol. 46:97-104(2009).
RN [2] {ECO:0000313|Proteomes:UP000161618}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20579821; DOI=10.1016/j.vetmic.2010.05.042;
RA Latimer E, Zong JC, Heaggans SY, Richman LK, Hayward GS.;
RT "Detection and evaluation of novel herpesviruses in routine and
RT pathological samples from Asian and African elephants: identification of
RT two new probosciviruses (EEHV5 and EEHV6) and two new gammaherpesviruses
RT (EGHV3B and EGHV5).";
RL Vet. Microbiol. 147:28-41(2011).
RN [3] {ECO:0000313|Proteomes:UP000161618}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=25231309; DOI=10.1128/JVI.01675-14;
RA Zong JC, Latimer EM, Long SY, Richman LK, Heaggans SY, Hayward GS.;
RT "Comparative genome analysis of four elephant endotheliotropic
RT herpesviruses, EEHV3, EEHV4, EEHV5, and EEHV6, from cases of hemorrhagic
RT disease or viremia.";
RL J. Virol. 88:13547-13569(2014).
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DR EMBL; KT832477; ALM26025.1; -; Genomic_DNA.
DR RefSeq; YP_009179342.1; NC_028379.1.
DR GeneID; 26196614; -.
DR KEGG; vg:26196614; -.
DR OrthoDB; 496at10239; -.
DR Proteomes; UP000161618; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003840; DNA_helicase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF02689; Herpes_Helicase; 2.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:ALM26025.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000161618}.
FT DOMAIN 64..251
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 448..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 957 AA; 106014 MW; 5A05A7BFD4770606 CRC64;
MTDASGGMFD TGFFLNMCSA SKVERIVDKV RALAARRLDA PLPYNWFGVM GDPERDPYDL
PFFPFTAVAV TGTAGAGKTV SVQVLAANLR CLCTGATVIA AQNLSSVLNR SKAAQVRTIH
KEFGFNSRHV SMLLRDSNVN ITDVASKQRH ELSRYWAVLS DIADSALEAG AAKARAMPIC
RHNIIVIDEA GVILEHMLHA VVFMYWFYNA LGDTPQYRRR LVPCLVCIGS PTQSEAITTT
FDHSRQNSIV RRGRDILSSL ICDPHMMRYC DTERNWVLFI NNKRCTDVDF GSLLKHIEFG
LPLTPEHLAY VDRFVRPGSF IKDPRNVPDM TRLFISHSEV QEYYRTLHAQ LQTSGDEKRN
LFVVPIYCIL NVREFEDYVE TIGNPHLKKE AWFEMNKPRI WNYSQFADQD LSNTTVVAAA
ASSSSSSAPS SSLSSLWATG GYGGSILGGE EDGGGDDDGH RAAVGGGGAV AGEEDEAHQL
FKCEFTYIRS SAVSVSSKLK CCVIGYEGTY DEFVEILQKD LFLEAVPYEQ INYAYSFLIG
LLYSGMFTFY THDRLSHDLL LEMRNIPLPH IEGISRNNHG DLCGSEYQWD AGRSHGANNE
GSGAAVAGAV AADVDARNVN MENYGAFRTT SGGRASGNDN VGEGEERSRD DDDEVRASGD
ATATGAAAGR GEGQGKVETE RGGGGVGEEE EGKDGGGNYY DAELDRMMCD ATGLYNDAFY
DRYENPPVSC STFEETIYMY TVFKDIFLKR YYASQKHTGN EFGGKTFVTY NRRNVSVRNN
RCEIVSHSKS FIGLLSYTSP AKVYTLQGYT HDMIMAFARS RHTKATQVAH ERRVPRLILK
DALGFMQVIE HNVSHFSDTA NGRTFAMCTA IDYGISPKIA MTITKSQGLS LDKVAVHFGD
GTKPLKLNQI YVAISRVTNP QHLIINVNPL RGEYINNNHI TRYIAMGLKN PHTHIIY
//
