ID A0A0S1Y2J8_9BORD Unreviewed; 700 AA.
AC A0A0S1Y2J8;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Fatty-acid oxidation protein subunit alpha {ECO:0000313|EMBL:ALM84243.1};
GN ORFNames=ASB57_15815 {ECO:0000313|EMBL:ALM84243.1};
OS Bordetella sp. N.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=1746199 {ECO:0000313|EMBL:ALM84243.1, ECO:0000313|Proteomes:UP000064621};
RN [1] {ECO:0000313|EMBL:ALM84243.1, ECO:0000313|Proteomes:UP000064621}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N {ECO:0000313|EMBL:ALM84243.1,
RC ECO:0000313|Proteomes:UP000064621};
RA Hou L.;
RT "Draft genome of Bordetella sp. N.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP013111; ALM84243.1; -; Genomic_DNA.
DR RefSeq; WP_057653087.1; NZ_CP013111.1.
DR AlphaFoldDB; A0A0S1Y2J8; -.
DR STRING; 1746199.ASB57_15815; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000064621; Chromosome.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000064621}.
FT DOMAIN 294..469
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 473..565
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 601..689
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 700 AA; 75548 MW; 72E9BE5C41F351D2 CRC64;
MSSAPSTRYE VQDRIAIITV DNPPVNALAP GAREDIVAGV ERANADDQVD AIILTGAGSH
FIAGADIRQF GKARGISTNT SSAAIAQSGK PVAAVIDGYC LGGGLEHALA CHYRLASPRA
KLGLPEIKIG LIPGGGGTQR LPRLIGARAA LDLILSGRHV KSDEALRLGL IDRVEESPLL
DAAVAFMKKM SAARPLPQVD GRPVTDADEG VFSNARKKAL RQGLRAPQYA IDMVELSVAT
PLEVGMEKER ERFTELENSD ESRALRYAFF AEKTSAKIPG APIDYQADPV KRPAVIGAGT
MGGGIAICFA EAGIPVRLLD SSPEALERGL QRIRSNYDAK LKRGTITEAQ IHERMARILP
VGSYEEIVDC DAVIEAVFER IDLKLEIFGK LNAIMNPDAL LLTNSSAIDI NTIAQATSRP
HLVAGAHFFA PANIMKLCEI VRSDTSSIET VLRAGRMARD LGKISVVAGT CDGFAANRSR
APLVTEMMLL LEEGALPQQI DKVMTDFGYP MGPFAVSDLS GLDVSYDTRK RRAAANPAYR
KLHVPDRLVE MGRFGQKVGA GWYRYEEGSR TPQPDPIIAD VIAGVARDFN IPQRTFSDEE
ILHRLLFASV NEACKIIEEG KALRASDIDV MWLNGFGFPR HRGGLLYWAD GIGAQDIHRQ
IQTWHTTYGA RWKPGALLAS IAASNGKLRD AEAGSFSTAE
//
