ID A0A0S2DBW6_LYSEN Unreviewed; 351 AA.
AC A0A0S2DBW6;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Alcohol dehydrogenase, zinc-containing {ECO:0000313|EMBL:ALN56025.1};
DE SubName: Full=NAD(P)-dependent alcohol dehydrogenase {ECO:0000313|EMBL:QCW24963.1};
GN ORFNames=FE772_04030 {ECO:0000313|EMBL:QCW24963.1}, GLE_0667
GN {ECO:0000313|EMBL:ALN56025.1};
OS Lysobacter enzymogenes.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Lysobacter.
OX NCBI_TaxID=69 {ECO:0000313|EMBL:ALN56025.1, ECO:0000313|Proteomes:UP000061569};
RN [1] {ECO:0000313|EMBL:ALN56025.1, ECO:0000313|Proteomes:UP000061569}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C3 {ECO:0000313|EMBL:ALN56025.1,
RC ECO:0000313|Proteomes:UP000061569};
RA Kobayashi D.Y.;
RT "Genome sequences of Lysobacter enzymogenes strain C3 and Lysobacter
RT antibioticus ATCC 29479.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QCW24963.1, ECO:0000313|Proteomes:UP000308311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YC36 {ECO:0000313|EMBL:QCW24963.1,
RC ECO:0000313|Proteomes:UP000308311};
RA Feng T.;
RT "Intraspecies Signal LeDSF and Interspecies Signal Indole Synergistically
RT Regulate the Twitching Motility of Lysobacter enzymogenes.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP013140; ALN56025.1; -; Genomic_DNA.
DR EMBL; CP040656; QCW24963.1; -; Genomic_DNA.
DR RefSeq; WP_057946200.1; NZ_CP040656.1.
DR AlphaFoldDB; A0A0S2DBW6; -.
DR STRING; 69.GLE_0667; -.
DR KEGG; lez:GLE_0667; -.
DR PATRIC; fig|69.6.peg.656; -.
DR OrthoDB; 9771084at2; -.
DR Proteomes; UP000061569; Chromosome.
DR Proteomes; UP000308311; Chromosome.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000061569};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 11..342
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 351 AA; 37484 MW; 0A8D0681587B5B49 CRC64;
MPKTAAYAAQ NAHSPLAPFS IDRRDPGPDE VLIDILYCGV CHSDIHQARD EWGGSIFPMV
PGHEIVGRVA RAGANVKTFN VGDAVGVGCF VDSCRECAQC KAGEEQYCDQ GMTGTYNSTE
RGSGAPTYGG YSTRITVDQA YVLRIPESIP LDRAAPLLCA GITTYSPLRH YGVKAGDELA
VVGLGGLGHM AVKLAVAMGA RVTVLSTSES KREAALELGA HAFAATRDKD TLKRLGRSFD
FVIDTVSGEH DYNAYLSLLK VDGTMVLLGV PEKPAPVAAG ALIMQRRKLG GSLIGGIRET
QEMLDFCAEH GVASDIELIG IESINEAYER MIKGDVRYRF VIDIASLENA A
//
