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Database: UniProt
Entry: A0A0S2DEY7_LYSEN
LinkDB: A0A0S2DEY7_LYSEN
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ID   A0A0S2DEY7_LYSEN        Unreviewed;       447 AA.
AC   A0A0S2DEY7;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   28-MAR-2018, entry version 18.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378,
GN   ECO:0000313|EMBL:ALN57100.1};
GN   ORFNames=GLE_1745 {ECO:0000313|EMBL:ALN57100.1};
OS   Lysobacter enzymogenes.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Lysobacter.
OX   NCBI_TaxID=69 {ECO:0000313|EMBL:ALN57100.1, ECO:0000313|Proteomes:UP000061569};
RN   [1] {ECO:0000313|EMBL:ALN57100.1, ECO:0000313|Proteomes:UP000061569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C3 {ECO:0000313|EMBL:ALN57100.1,
RC   ECO:0000313|Proteomes:UP000061569};
RA   Kobayashi D.Y.;
RT   "Genome sequences of Lysobacter enzymogenes strain C3 and Lysobacter
RT   antibioticus ATCC 29479.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|SAAS:SAAS00984457}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; CP013140; ALN57100.1; -; Genomic_DNA.
DR   RefSeq; WP_057947021.1; NZ_CP013140.1.
DR   EnsemblBacteria; ALN57100; ALN57100; GLE_1745.
DR   KEGG; lez:GLE_1745; -.
DR   PATRIC; fig|69.6.peg.1721; -.
DR   KO; K03601; -.
DR   OMA; NARRRWP; -.
DR   Proteomes; UP000061569; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000061569};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558,
KW   ECO:0000313|EMBL:ALN57100.1};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000061569}.
FT   DOMAIN       13    103       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      126    440       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      267    287       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   447 AA;  50014 MW;  8AC2BB541046B8A7 CRC64;
     MPPSSPDEVL TPSQLNTLAR DLLEDTFPLI WVEGELGNLS RPSSGHLYMT LKDARAQVRC
     AMFKPKSSWL KFVPREGLRV LARGRLTLYE ARGDYQLVLD HMEEAGEGAL RRAFEELKAR
     LAAEGLFDRE RKRELPRFPE RIAIITSPSG AAVRDVLSVL GRRFPLAQAE VLPVPVQGDG
     AAEKIVAMLQ RAQAAQRYDV IVLARGGGSL EDLWAFNDER LARAIAASDV PVVSAIGHET
     DFTLADFAAD VRAPTPSVAA ELLVPQREDL LHRLRVLEAR LHNLHSQRLR QAMQRTDRAG
     LRLNALRPQA RLAALRNRQQ DALRRLEQAW RLRVERETAR LRHSDAVLRA HHPQRRIARL
     RERLAALAPR PRAALARRLH GDALRLRGLA RSLAAVSPLA TVARGYAIVQ HDDGRVVRSV
     LDAAPGDRLS ARVQDGQIRV RVEPRED
//
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