ID A0A0S2DFX5_LYSEN Unreviewed; 118 AA.
AC A0A0S2DFX5;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=NADH-quinone oxidoreductase subunit A {ECO:0000256|HAMAP-Rule:MF_01394};
DE EC=7.1.1.- {ECO:0000256|HAMAP-Rule:MF_01394};
DE AltName: Full=NADH dehydrogenase I subunit A {ECO:0000256|HAMAP-Rule:MF_01394};
DE AltName: Full=NDH-1 subunit A {ECO:0000256|HAMAP-Rule:MF_01394};
DE AltName: Full=NUO1 {ECO:0000256|HAMAP-Rule:MF_01394};
GN Name=nuoA {ECO:0000256|HAMAP-Rule:MF_01394,
GN ECO:0000313|EMBL:ALN57509.1};
GN ORFNames=BV903_015810 {ECO:0000313|EMBL:UZW58775.1}, D9T17_13265
GN {ECO:0000313|EMBL:ROU06423.1}, FE772_10895
GN {ECO:0000313|EMBL:QCW26103.1}, GLE_2159 {ECO:0000313|EMBL:ALN57509.1},
GN LEN_2880 {ECO:0000313|EMBL:BAV98367.1}, SAMN05421681_10492
GN {ECO:0000313|EMBL:SDX17054.1};
OS Lysobacter enzymogenes.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Lysobacter.
OX NCBI_TaxID=69 {ECO:0000313|EMBL:ALN57509.1, ECO:0000313|Proteomes:UP000061569};
RN [1] {ECO:0000313|EMBL:ALN57509.1, ECO:0000313|Proteomes:UP000061569}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C3 {ECO:0000313|EMBL:ALN57509.1,
RC ECO:0000313|Proteomes:UP000061569};
RA Kobayashi D.Y.;
RT "Genome sequences of Lysobacter enzymogenes strain C3 and Lysobacter
RT antibioticus ATCC 29479.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000218824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M497-1 {ECO:0000313|Proteomes:UP000218824};
RA Takami H., Toyoda A., Uchiyama I., Itoh T., Takaki Y., Arai W., Nishi S.,
RA Kawai M., Shinya K., Ikeda H.;
RT "Complete genome sequence and expression profile of the commercial lytic
RT enzyme producer, Lysobacter enzymogenes M497-1.";
RL DNA Res. 0:0-0(2016).
RN [3] {ECO:0000313|EMBL:SDX17054.1, ECO:0000313|Proteomes:UP000183696}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29487 {ECO:0000313|EMBL:SDX17054.1,
RC ECO:0000313|Proteomes:UP000183696};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:BAV98367.1, ECO:0000313|Proteomes:UP000218824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M497-1 {ECO:0000313|EMBL:BAV98367.1,
RC ECO:0000313|Proteomes:UP000218824};
RX PubMed=28065880; DOI=.1093/dnares/dsw055;
RA Takami H., Toyoda A., Uchiyama I., Itoh T., Takaki Y., Arai W., Nishi S.,
RA Kawai M., Shinya K., Ikeda H.;
RT "Complete genome sequence and expression profile of the commercial lytic
RT enzyme producer Lysobacter enzymogenes M497-1.";
RL DNA Res. 24:169-177(2017).
RN [5] {ECO:0000313|EMBL:UZW58775.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B25 {ECO:0000313|EMBL:UZW58775.1};
RX PubMed=28473380; DOI=10.1128/genomea.00271-17;
RA Hernandez I., Fernandez C.;
RT "Draft Genome Sequence and Assembly of a Lysobacter enzymogenes Strain with
RT Biological Control Activity against Root Knot Nematodes.";
RL Genome Announc. 5:e00271-e00217(2017).
RN [6] {ECO:0000313|EMBL:ROU06423.1, ECO:0000313|Proteomes:UP000275910}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OH11 {ECO:0000313|EMBL:ROU06423.1,
RC ECO:0000313|Proteomes:UP000275910};
RA Liu F., Zhao Y., Qian G., Chen Y., Xu H.;
RT "The genome of Lysobacter enzymogenes OH11.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QCW26103.1, ECO:0000313|Proteomes:UP000308311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YC36 {ECO:0000313|EMBL:QCW26103.1,
RC ECO:0000313|Proteomes:UP000308311};
RA Feng T.;
RT "Intraspecies Signal LeDSF and Interspecies Signal Indole Synergistically
RT Regulate the Twitching Motility of Lysobacter enzymogenes.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:UZW58775.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B25 {ECO:0000313|EMBL:UZW58775.1};
RA Fernandez G., Fernandez C., Hernandez I.;
RT "Improved assembly of Lysobacter enzymogenes B25.";
RL Submitted (OCT-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur
CC (Fe-S) centers, to quinones in the respiratory chain. The immediate
CC electron acceptor for the enzyme in this species is believed to be
CC ubiquinone. Couples the redox reaction to proton translocation (for
CC every two electrons transferred, four hydrogen ions are translocated
CC across the cytoplasmic membrane), and thus conserves the redox energy
CC in a proton gradient. {ECO:0000256|HAMAP-Rule:MF_01394}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01394,
CC ECO:0000256|RuleBase:RU003639};
CC -!- SUBUNIT: NDH-1 is composed of 14 different subunits. Subunits NuoA, H,
CC J, K, L, M, N constitute the membrane sector of the complex.
CC {ECO:0000256|HAMAP-Rule:MF_01394}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01394,
CC ECO:0000256|RuleBase:RU003639}; Multi-pass membrane protein
CC {ECO:0000256|HAMAP-Rule:MF_01394, ECO:0000256|RuleBase:RU003639}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family.
CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|HAMAP-Rule:MF_01394,
CC ECO:0000256|RuleBase:RU003639}.
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DR EMBL; CP013140; ALN57509.1; -; Genomic_DNA.
DR EMBL; AP014940; BAV98367.1; -; Genomic_DNA.
DR EMBL; CP040656; QCW26103.1; -; Genomic_DNA.
DR EMBL; RCTY01000033; ROU06423.1; -; Genomic_DNA.
DR EMBL; FNOG01000004; SDX17054.1; -; Genomic_DNA.
DR EMBL; CP110813; UZW58775.1; -; Genomic_DNA.
DR RefSeq; WP_057947326.1; NZ_RCTY01000033.1.
DR STRING; 69.GLE_2159; -.
DR KEGG; lem:LEN_2880; -.
DR KEGG; lez:GLE_2159; -.
DR PATRIC; fig|69.6.peg.2122; -.
DR OrthoDB; 9791970at2; -.
DR Proteomes; UP000061569; Chromosome.
DR Proteomes; UP000183696; Unassembled WGS sequence.
DR Proteomes; UP000190203; Chromosome.
DR Proteomes; UP000218824; Chromosome.
DR Proteomes; UP000275910; Unassembled WGS sequence.
DR Proteomes; UP000308311; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.1610; NADH:ubiquinone/plastoquinone oxidoreductase, chain 3; 1.
DR HAMAP; MF_01394; NDH1_NuoA; 1.
DR InterPro; IPR023043; NAD(P)H_OxRDtase_bac/plastid.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR PANTHER; PTHR11058:SF9; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01394};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01394};
KW NAD {ECO:0000256|HAMAP-Rule:MF_01394, ECO:0000256|RuleBase:RU003639};
KW Oxidoreductase {ECO:0000313|EMBL:BAV98367.1};
KW Quinone {ECO:0000256|HAMAP-Rule:MF_01394, ECO:0000256|RuleBase:RU003639};
KW Reference proteome {ECO:0000313|Proteomes:UP000061569};
KW Translocase {ECO:0000256|HAMAP-Rule:MF_01394};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01394};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01394};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01394};
KW Ubiquinone {ECO:0000256|HAMAP-Rule:MF_01394}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01394"
FT TRANSMEM 60..81
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01394"
FT TRANSMEM 87..110
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01394"
SQ SEQUENCE 118 AA; 13312 MW; 995BB9DE5F4FAC6B CRC64;
MLAEYLPTLL FLIVASGIGV ALLVVGNVLG PKRPTAEKLS PYECGFEAFE DARMQFDVRY
YLIAIQFIIF DLEIIFIVPW ATVFRDLGVV GLIEMGIFAS MLLLGFVYVW KKGALEWE
//
