ID A0A0S2DHM7_LYSEN Unreviewed; 2241 AA.
AC A0A0S2DHM7;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:ALN57906.1};
GN ORFNames=GLE_2557 {ECO:0000313|EMBL:ALN57906.1};
OS Lysobacter enzymogenes.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Lysobacter.
OX NCBI_TaxID=69 {ECO:0000313|EMBL:ALN57906.1, ECO:0000313|Proteomes:UP000061569};
RN [1] {ECO:0000313|EMBL:ALN57906.1, ECO:0000313|Proteomes:UP000061569}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C3 {ECO:0000313|EMBL:ALN57906.1,
RC ECO:0000313|Proteomes:UP000061569};
RA Kobayashi D.Y.;
RT "Genome sequences of Lysobacter enzymogenes strain C3 and Lysobacter
RT antibioticus ATCC 29479.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
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DR EMBL; CP013140; ALN57906.1; -; Genomic_DNA.
DR STRING; 69.GLE_2557; -.
DR KEGG; lez:GLE_2557; -.
DR PATRIC; fig|69.6.peg.2517; -.
DR Proteomes; UP000061569; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000061569}.
FT DOMAIN 1011..1085
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1082..1156
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2145..2220
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2241 AA; 242191 MW; 499D3EB71186E966 CRC64;
MASSTPASPA STSPAPASAI LASYWRKGGT LERGPQGWTM PAGEGEALAP VERRALDEHR
DEIDAILAAQ PDYFDWRPLQ ANPRALWFLH RLAPHSAAYH CTAVLGMDGR IEDAQLAAAF
ERLCARHPML RAQFGERDGE PCYRILAEHR NECRALVADA DLAQAKRTLL AEADRPFALE
QAAVMRLASV RVGQRVVVSL VLHHIVADFY SCEILARELV AELSGDTAGA AVVASYEQWS
RENAEYLDSD RGRDAAHYWQ TLLRDAPSEL HLPTDFARPP LRQWSGERIE RDLDPGLSAQ
VRATATALGV TPYIVLLAAY QLWLWRLSGQ ADFVIGTPTL GRHAARHRHL VGYLANPVPV
RVRIDPQQRF ADLSTALKAQ MDASLRRQRY PLTRLLDELA LPRRSDRAPL FQHFFTYSQA
RLGWGEAVAM ETLHMGMRGA AHELILTVFE NGADLCCQIG YSDALYGAQT VSGWLDGYVE
LLARIVADPS RRLDALDWAG HGQAGERGET IDAGARHAIK RIEAAPDACI ALHEGERTLD
YAALRARART LAAGLQAHGG DVVALALPRG ETQIVAMLAA WYAGQAWLAL DPRLPDERLA
YMVEDSGARV VLGDGPRPAW LPTAAAWFAP DALTGKSLGE TARDPDDVAY LIYTSGSTGQ
PKGVAVSHAN LCGYVEGVLA RLQQDRPLAQ DAVFSTLATA SADLGHTALF GALLSGRGLR
LIDDALARDP HALAEHLQRH RVDVLKIVPS HLQALLAAEQ PQRLLPRQAL VFGGEALPWP
LVDQIRALAP HCRVFNHYGP TETTVGATCI DTERAPRGTA SVAIGMPLPN YRAYVLDQQG
RAVAQGAIGE LYIGGIGVAR GYWRREALSA ERFLPDPLDP SQRVYRTGDR VQRLPAGELV
FHGRADDQVK IRGYRVEPGE VEQRLRAVPG VEQAVVLAAP GANGTQTLAA FYRGAHADPL
ATLRAALPDY MVPARCLRVE TVPVTANGKV DRAALLALLD AAEPAAVAQD APLEPFEARL
AALWQPLFPQ ASIGPQSSFF GLGGDSILAL RLVASARKSG IELTPALLLE TASLRELAQR
LRPPSPTELL LRQACAQALG RDRIDRDADF FELGGDSIAA LKLVARARQA GLALTPAELL
EHRPLSALAA HLDRAADAID AVAPAPVEPT PAAALAPFGL LDAAEGARLR AAHADAIDAY
PLSPLQEGLL FAALAAPDSG QYLNQQVLSL TGPLDRARLV AAWSALQQRH ESLRVGFDWD
HAGRPVQWLP VQAGPSLHEH DWSGRDSART QAELWALCER ERDSAFALER PGLLRLHLVC
AGPSQAWLVL TVHHLVIDRW SAAVLLQELF ALYAGEALPP APRYRDYIGW LGAQPVQGED
AFWRAQLADY EGGEELPAPA APGEGRYVTE ARLARAEIVA LRECAARLQV PLTSVLQAAW
ALLLSRYTNS ADVCFGLTVS GRPPALAQAE RMTGLFINTL PMRLRLEAGQ DFGALCRKAR
DLSFAVQAHD RLPLARIAEL AGVPNGAALL HSLLVIENIP LDTAARLPDG LAYEFVHAAS
ATNLPLLVQI TPEDDSLHLL LQSQRNQLPD DFVERVLGDW LRLLRGVAGL VDTPVGQIGL
LAPADWAAWR ARGQGPALPF VPERMPDSLA DCIERAAAWH PAEPALVGGG RCLSYDELNR
RANRLAHHLR ALGLSAGERV ALVADRSVAI TVAMLAVLKA GGAYVPIDPE HPHERIAFVL
ADAGCRFALA RGTGLACVSG GASRVLDLDS EALLGELAAQ PERNPARNHD AASPAYVIYT
SGSTGQPKGV LVPHRGPLRL MQAVQAMLPA GPGDRVLQFT GLHFDMSVLE WLCAWTQGAC
LHLIERELTR SGDGLLALLA EQAITHVVAQ PAVFAPLPPP SLPALRYLLL GGDVCPTELA
ERWGRGRVVL NGYGPTEASV LVTADRYEPG RAIALGHPLP HAQCYVLDWS GQPCPPESVG
ELHLAGDYLA HGYLGLPEKT AAAFRTPERG PLAGVRLYAT GDRVRQRRDG RLEFLGRRDH
QVKIRGLRIE LGEVEAALRA QAGVAEAVAL VHRPGQDNAC LVAFVQGEAD PAALREALRL
RLPAHLLPAH IECRATLPQS ASRKVDRRAL AALVEHVLRP QVRLAPASDS ERRLLAVWQR
LFQRDAIGVT EDFFALGGHS LLATRLASAI ALEFDLRLDL RRLFATTTIR DQALLIDALQ
AAALASSAGD GAESVIESGF L
//
