ID A0A0S2K4L2_9GAMM Unreviewed; 648 AA.
AC A0A0S2K4L2;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=PP2015_2523 {ECO:0000313|EMBL:ALO43013.1};
OS Pseudoalteromonas phenolica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=161398 {ECO:0000313|EMBL:ALO43013.1, ECO:0000313|Proteomes:UP000061457};
RN [1] {ECO:0000313|EMBL:ALO43013.1, ECO:0000313|Proteomes:UP000061457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 12086 {ECO:0000313|EMBL:ALO43013.1,
RC ECO:0000313|Proteomes:UP000061457};
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; CP013187; ALO43013.1; -; Genomic_DNA.
DR RefSeq; WP_058030706.1; NZ_CP013187.1.
DR AlphaFoldDB; A0A0S2K4L2; -.
DR STRING; 161398.PP2015_2523; -.
DR KEGG; pphe:PP2015_2523; -.
DR PATRIC; fig|161398.10.peg.2577; -.
DR OrthoDB; 9806424at2; -.
DR Proteomes; UP000061457; Chromosome I.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ALO43013.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000061457};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..134
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 269..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 71995 MW; 2D029D1675183007 CRC64;
MKLYIAEKPS LGRAIANALP KPHKNNDGFI EAANGDIVTW CIGHLLEQAE PEAYDPKFKK
WAIADLPIVP EQWQLVAKSK TKKQFNTVKK LIKSAETIVN AGDPDREGQL LIDEMINFCG
ATKAQKEQTL RCLISDLNPS AVKQAINNLK PNLDFLSLSV SALSRARADW LYGINMTRMS
TIKGQQAGYQ GVLSIGRVQT PVLGLVVYRD WEIANFVSKP FYEVEAKLNT QAGASYIGKW
QPSDACQPYM DEEGRVLVKG LAENVASRVK NQSGEVSKDK STQSKKSRPL PHSLSTLQIE
AAKVFGMNAQ SVLDTCQSLY ERHKLITYPR SDCRYLPKDH YKERGSVVDA IDTISDKLSA
FTGKANLEIK SSAWNDSKVG AHHAIIPTSK KSSGALSQNE QNVYYLIARH YLAQFFEPSV
YAEREIHTLI QGGLFTSKFK SLIDKGWEVL FNKQEKGEAE LTQLPMLQKG EQVQCVDAQV
IEKHTSPPKH FTDATLLAAM TGIARYVTDP EIKKILKETD GIGTEATRAG IIELLFKRQY
LQRKGKAIHS TEIGQSVIKA LPESVGRPDM TAVWEQSLEQ IYQKSQSYNQ FMGSVEVHLN
RLLQDTQTAS FQGLAGKGKA SFKRFKKGKR SAGKGKSAVK SPRAKSKA
//
