ID A0A0S2W505_9FIRM Unreviewed; 1116 AA.
AC A0A0S2W505;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=IB211_01980c {ECO:0000313|EMBL:ALP94371.1};
OS Intestinimonas butyriciproducens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Intestinimonas.
OX NCBI_TaxID=1297617 {ECO:0000313|EMBL:ALP94371.1, ECO:0000313|Proteomes:UP000064844};
RN [1] {ECO:0000313|EMBL:ALP94371.1, ECO:0000313|Proteomes:UP000064844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF211 {ECO:0000313|EMBL:ALP94371.1,
RC ECO:0000313|Proteomes:UP000064844};
RX PubMed=26620920; DOI=10.1038/ncomms10062;
RA Bui T.P., Ritari J., Boeren S., de Waard P., Plugge C.M., de Vos W.M.;
RT "Production of butyrate from lysine and the Amadori product fructoselysine
RT by a human gut commensal.";
RL Nat. Commun. 6:10062-10062(2015).
RN [2] {ECO:0000313|Proteomes:UP000064844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF211 {ECO:0000313|Proteomes:UP000064844};
RA de Vos W.M., Bui N.T.P., Plugge C.M., Ritari J.;
RT "A butyrogenic pathway from the amino acid lysine in a human gut
RT commensal.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP011307; ALP94371.1; -; Genomic_DNA.
DR RefSeq; WP_058117922.1; NZ_CP011307.1.
DR AlphaFoldDB; A0A0S2W505; -.
DR STRING; 1297617.IB211_01980c; -.
DR KEGG; ibu:IB211_01980c; -.
DR PATRIC; fig|1297617.4.peg.2044; -.
DR eggNOG; COG3857; Bacteria.
DR Proteomes; UP000064844; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR049035; ADDB_N.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR Pfam; PF21445; ADDB_N; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000064844}.
FT DOMAIN 266..549
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 1116 AA; 124290 MW; 61F0566A8BB4483A CRC64;
MLRLLLGRAG AGKSTAILRR IAASGGARRQ LLIVPEQASH ETERRLCAVA GNQVSLYAEV
LSFTRLGSRV FSQAGGLAAP ALDPGGRLLL MCAALKSVSG SLTVYARPSR KPAFLTGLLA
TLDECKQYQV FPDDLARAGE AVEGREGEKL RDLGLIFGAY EALSAQTAAD PRDRITRLAQ
GLKECGYARG MDIYIDGFTD FTPQQGLVLR ALLRQAESVT VALTSDRLDR DTGASNIFAP
ARRTAAYLRR MAGEEHVPAE AEYLPQRGEG RSAALARLEA NLFADVPAAA ASPAPEIGLF
SALRPRSEVE YAASEVLRLV REEGCRFRDI ALVARGFERY APLVEEIFPR YGIPVFLDAM
TDILQKPVFA VVTGALDVVA RGYSYDDVFR YLKTGLAGVS RGECDELENY VLKWGIKGNR
WTAKADWDMH PRGYGFPMTG PDREWIARVN EARRKVVGPL EGLRKNRDRT GRGQAMALYR
FLESIRLPEQ LAERSERLRA RGEFKRAEEY GQLWEILCGG LEQCAGLLGE EPMELQEFAQ
LFKLVLSQYD VGTIPVSLDR VNAGEAARLG NREVKALFFL GADDGAVPQV VPAPGLFTDD
DRSLLSSFGL ELSPQLADKL DREMTIVYEA CARPSHWLTV SWAAMDPQGE EKRPSFLVSR
LRLLFPQNPL LREQDMSGTF RLSAPGPAVE LAGRYPQVRR ILSGRAEYAP RVRRMEDALH
AERGSLSPEA VQRLYGRHVP MSASRMDKYQ SCHFSYFMQY GLNAKARRTA GFQAPEYGTF
VHYVLEHVLQ DPACRVGDGS GGWSYDRERA RRLIREIMER YIAEELGGLE NKTPRFLYLF
QRLVRPVTQV VENVLDELGA SQFRPIAFEL GFGAKGELPP VELTVDGITV SISGFVDRLD
GWVHNGRLYL RVVDYKTGRK SFDLTEVWNG LGLQMLLYLF TLEDQGSALY HREVTPAGVL
YLPAREATVQ GRRDMDEAER RKRADAELRR RGLILDDPEV VEAMESPGEE WLRFLPLRVS
GRTGAITGDA LVSAERLGRL KVHTQRILRE IARELSAGNI AADPFWRGPE KNACLYCDYA
AACHFEEGRG GDRVRYLPAL DGEAFWQAVA AEETEK
//
