ID A0A0S2W571_9FIRM Unreviewed; 492 AA.
AC A0A0S2W571;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anthranilate synthase component 1 {ECO:0000256|ARBA:ARBA00020653};
GN ORFNames=IB211_01769 {ECO:0000313|EMBL:ALP94160.1};
OS Intestinimonas butyriciproducens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Intestinimonas.
OX NCBI_TaxID=1297617 {ECO:0000313|EMBL:ALP94160.1, ECO:0000313|Proteomes:UP000064844};
RN [1] {ECO:0000313|EMBL:ALP94160.1, ECO:0000313|Proteomes:UP000064844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF211 {ECO:0000313|EMBL:ALP94160.1,
RC ECO:0000313|Proteomes:UP000064844};
RX PubMed=26620920; DOI=10.1038/ncomms10062;
RA Bui T.P., Ritari J., Boeren S., de Waard P., Plugge C.M., de Vos W.M.;
RT "Production of butyrate from lysine and the Amadori product fructoselysine
RT by a human gut commensal.";
RL Nat. Commun. 6:10062-10062(2015).
RN [2] {ECO:0000313|Proteomes:UP000064844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF211 {ECO:0000313|Proteomes:UP000064844};
RA de Vos W.M., Bui N.T.P., Plugge C.M., Ritari J.;
RT "A butyrogenic pathway from the amino acid lysine in a human gut
RT commensal.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Heterotetramer consisting of two non-identical subunits: a
CC beta subunit (TrpG) and a large alpha subunit (TrpE).
CC {ECO:0000256|ARBA:ARBA00011575}.
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DR EMBL; CP011307; ALP94160.1; -; Genomic_DNA.
DR RefSeq; WP_058117777.1; NZ_CP011307.1.
DR AlphaFoldDB; A0A0S2W571; -.
DR STRING; 1297617.IB211_01769; -.
DR KEGG; ibu:IB211_01769; -.
DR PATRIC; fig|1297617.4.peg.1818; -.
DR eggNOG; COG0147; Bacteria.
DR Proteomes; UP000064844; Chromosome.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF48; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:ALP94160.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000064844}.
FT DOMAIN 32..172
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 222..475
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 492 AA; 54600 MW; E1FF65A77378171E CRC64;
MYYPTLEEAR QIAGTGDFRS IPITREILSD FTTPIQAMRI LRTESSHCFL LESAADSAQW
GRYTFLGFDP TLEVTCADGI LRLKRGTQTA EASASHPGGT LRRLLAEHKS PRLPGLPPFT
GGLVGYFSYD YIKYAEPSLH LNAEDQEGFH DMDLMLFEKI IAFDNFRQKL VLIVNADVGD
LDRSYPAACA ELDRIDALLH SGNLLPSRPA HLTTPLRPLF DQASYCAMVE RAKQYIREGD
IFQVVLSNRL EAGFEGSLLD TYRILRTENP SPYMFYFTSD DIELAGASPE TLVKLENGIL
HTFPLAGTRP RGRTAEEDLA LEAELLADEK ELAEHNMLVD LGRNDIGRIS RFGTVEVERY
LSVERFSHVM HIGSTVRGVL REDRDAVDAV DAILPAGTLS GAPKLRACEI INELENNKRG
VYGGAIGYLD FTGNMDTCIA IRLAFRKNGK VFIRSGAGIV ADSVPEKEYL ECINKAKAVV
KALELAQKEA DL
//
