GenomeNet

Database: UniProt
Entry: A0A0S3QS74_THET7
LinkDB: A0A0S3QS74_THET7
Original site: A0A0S3QS74_THET7 
ID   A0A0S3QS74_THET7        Unreviewed;       874 AA.
AC   A0A0S3QS74;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=Chaperone protein ClpB {ECO:0000256|RuleBase:RU362034};
GN   Name=clpB {ECO:0000256|RuleBase:RU362034};
GN   ORFNames=TST_0366 {ECO:0000313|EMBL:BAT71174.1};
OS   Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 /
OS   ABI70S6).
OC   Bacteria; Aquificota; Aquificae; Aquificales.
OX   NCBI_TaxID=1298851 {ECO:0000313|EMBL:BAT71174.1, ECO:0000313|Proteomes:UP000063234};
RN   [1] {ECO:0000313|Proteomes:UP000063234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6
RC   {ECO:0000313|Proteomes:UP000063234};
RX   PubMed=29420286; DOI=10.1126/science.aao3407;
RA   Nunoura T., Chikaraishi Y., Izaki R., Suwa T., Sato T., Harada T., Mori K.,
RA   Kato Y., Miyazaki M., Shimamura S., Yanagawa K., Shuto A., Ohkouchi N.,
RA   Fujita N., Takaki Y., Atomi H., Takai K.;
RT   "A primordial and reversible TCA cycle in a facultatively
RT   chemolithoautotrophic thermophile.";
RL   Science 359:559-563(2018).
CC   -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC       involved in the recovery of the cell from heat-induced damage, in
CC       cooperation with DnaK, DnaJ and GrpE. {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC       {ECO:0000256|ARBA:ARBA00026057}.
CC   -!- SUBUNIT: Homohexamer; The oligomerization is ATP-dependent.
CC       {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362034}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP013035; BAT71174.1; -; Genomic_DNA.
DR   RefSeq; WP_068549095.1; NZ_AP013035.1.
DR   AlphaFoldDB; A0A0S3QS74; -.
DR   STRING; 1298851.TST_0366; -.
DR   KEGG; ttk:TST_0366; -.
DR   PATRIC; fig|1298851.3.peg.378; -.
DR   OMA; SKMMQGE; -.
DR   Proteomes; UP000063234; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042026; P:protein refolding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0009408; P:response to heat; IEA:UniProtKB-UniRule.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR017729; ATPase_T6SS_ClpV1.
DR   InterPro; IPR017730; Chaperonin_ClpB.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR03346; chaperone_ClpB; 1.
DR   NCBIfam; TIGR03345; VI_ClpV1; 1.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU362034};
KW   Cytoplasm {ECO:0000256|RuleBase:RU362034};
KW   Hydrolase {ECO:0000313|EMBL:BAT71174.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:BAT71174.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000063234};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}; Stress response {ECO:0000256|RuleBase:RU362034}.
FT   DOMAIN          4..146
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   COILED          412..570
FT                   /evidence="ECO:0000256|RuleBase:RU362034"
SQ   SEQUENCE   874 AA;  99010 MW;  A8BFC6043583356D CRC64;
     MISIDRFTIK AREALAKSKE IASSKGHQQI EPEHLFYALI DQEGVATELL KKCGVDLSLL
     KRRVEESFEK FPQVSGVGEV YLSPKFNRVL ETADKLAKEL KDEYISTEHL LLAIAKEPGS
     YIHDILKSYG VGFEELLKAL EDVRGPHRVT DQAAEERYQA LKRYCVDLTE LARQGKLDPV
     IGRDEEIRRV IQILSRRRKN NPCLIGDAGV GKTAIVEGLA QRIAKGDVPT TLKDKSILAL
     DMGALLAGAK FRGEFEERLK AVIKEIQEKE GKIILFIDEI HTLVGAGRAE GAMDAANILK
     PALARGELHC IGATTVDEYR KYIEKDPALE RRFQPVYVTE PSVEETISIL RGLKERYEIH
     HGVRISDSAI VAAAYLSARY IPDRRLPDKA VDLIDEAAAK LRMEIDSMPS ELDDIARKIR
     QLEIEREVLK LEGKSSEELE VIEKKIADLK EEFDRLKAHW LAEKEAIQRV RELKEQINNA
     QHELELAERQ GDLEKAARIK YDVLMRLNKE LEEANKKLAQ IQSKRKLLKE VVEDEDIAEI
     ISKWTGIPVH KLLEEEAQKL LRMEEELHKR VIGQDVAVRA VSETIRRARA GLSDPNRPLG
     SFLFLGPTGV GKTELAKALA EFLFDDENAM VRIDMSEYME RHSVSRLIGA PPGYVGYEEG
     GQLTEAVRRR PYSVVLLDEI EKAHPEVFNI LLQILEDGRL TDSKGNTVSF KNTVIIMTSN
     IGSEYITPPP ADFGTPEYEK YYNEMKEKVL SALRGYFKPE FLNRIDEIIV FHSLGKEHVK
     QIADLMLNRV KKRLAEKKID LVWDDAVKEY LAEVGFDSVY GARPLRRTIQ RLVENTLAEL
     ILKGEVKPGD KVVLEATSEG IGFKKEERLL KQVA
//
DBGET integrated database retrieval system