ID A0A0S3QT13_THET7 Unreviewed; 321 AA.
AC A0A0S3QT13;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Octaprenyl-diphosphate synthase {ECO:0000313|EMBL:BAT71478.1};
DE EC=2.5.1.90 {ECO:0000313|EMBL:BAT71478.1};
GN Name=ispB {ECO:0000313|EMBL:BAT71478.1};
GN ORFNames=TST_0672 {ECO:0000313|EMBL:BAT71478.1};
OS Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 /
OS ABI70S6).
OC Bacteria; Aquificota; Aquificae; Aquificales.
OX NCBI_TaxID=1298851 {ECO:0000313|EMBL:BAT71478.1, ECO:0000313|Proteomes:UP000063234};
RN [1] {ECO:0000313|Proteomes:UP000063234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6
RC {ECO:0000313|Proteomes:UP000063234};
RX PubMed=29420286; DOI=10.1126/science.aao3407;
RA Nunoura T., Chikaraishi Y., Izaki R., Suwa T., Sato T., Harada T., Mori K.,
RA Kato Y., Miyazaki M., Shimamura S., Yanagawa K., Shuto A., Ohkouchi N.,
RA Fujita N., Takaki Y., Atomi H., Takai K.;
RT "A primordial and reversible TCA cycle in a facultatively
RT chemolithoautotrophic thermophile.";
RL Science 359:559-563(2018).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|ARBA:ARBA00006706, ECO:0000256|RuleBase:RU004466}.
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DR EMBL; AP013035; BAT71478.1; -; Genomic_DNA.
DR RefSeq; WP_068549472.1; NZ_AP013035.1.
DR AlphaFoldDB; A0A0S3QT13; -.
DR STRING; 1298851.TST_0672; -.
DR KEGG; ttk:TST_0672; -.
DR PATRIC; fig|1298851.3.peg.698; -.
DR OrthoDB; 9805316at2; -.
DR Proteomes; UP000063234; Chromosome.
DR GO; GO:0106350; F:octaprenyl pyrophosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR12001:SF87; OCTAPRENYL DIPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000063234};
KW Transferase {ECO:0000256|RuleBase:RU004466, ECO:0000313|EMBL:BAT71478.1}.
SQ SEQUENCE 321 AA; 35980 MW; 0B72683C97CFEF6E CRC64;
MIIKEVAQYL KEDLNEVERI LNENLHSTIK VIPELSTYIL ESGGKRFRPM LALLSAKMCG
YHGVEAAVAG AVIEYIHTAT LLHDDVVDES DTRRGRKAAH KIWGNQASIL VGDFLFARSF
WLMTENLPPE ALGVMSDACV NLAEGEILQL IKSFDINTTE EDYYNIIYGK TAALISAACE
VGAILGNGDR EALRRYGTEI GYAFQISDDL LDIVGDPEKT GKPVGNDFKE GKVTLPLIFA
LKRASREEYK HIRDLLLAEE LEDGAFQYVK EVILKYQGVE EAINRVKDHG KRALEALRSF
DNSKEKEFLI GIAEYLAERD Y
//
