ID A0A0S3SJK5_PHAAN Unreviewed; 1986 AA.
AC A0A0S3SJK5;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN Name=Vigan.07G187100 {ECO:0000313|EMBL:BAT92990.1};
GN ORFNames=VIGAN_07187100 {ECO:0000313|EMBL:BAT92990.1};
OS Vigna angularis var. angularis.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Vigna.
OX NCBI_TaxID=157739 {ECO:0000313|EMBL:BAT92990.1, ECO:0000313|Proteomes:UP000291084};
RN [1] {ECO:0000313|EMBL:BAT92990.1, ECO:0000313|Proteomes:UP000291084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Shumari {ECO:0000313|Proteomes:UP000291084};
RX PubMed=26616024; DOI=10.1038/srep16780;
RA Sakai H., Naito K., Ogiso-Tanaka E., Takahashi Y., Iseki K., Muto C.,
RA Satou K., Teruya K., Shiroma A., Shimoji M., Hirano T., Itoh T., Kaga A.,
RA Tomooka N.;
RT "The power of single molecule real-time sequencing technology in the de
RT novo assembly of a eukaryotic genome.";
RL Sci. Rep. 5:16780-16780(2015).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP015040; BAT92990.1; -; Genomic_DNA.
DR Proteomes; UP000291084; Chromosome 7.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000291084};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 36..374
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1191..1427
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1585..1965
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 425..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1547..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1547..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1986 AA; 215572 MW; E163941C94DE744B CRC64;
MRSESDPNIN RFAVSHLQQN PNSIRRSLHN NIPVMWTNVF KIGSLHQISW FQYLPHEPDL
NPLPDKSVKV DQKDAANLLV LSSHLQLQKE GFLSTWTNSF VGPWDPSQGL HNPDEKIKLW
LFLPGRHSSV VETAQPAVCR LRVVASGLWL APGDSEEVAA ALSQALRSRI ERALLGLCYM
RFGDVFSKFH QFQSEELFRR GQPAVEFAFA ATEEAIFIHV IVSSKHIRML TTSDLEKVLK
HSVESTCRLP VIVSPHGIRG SLTGCSPSDL VKQSYFSSTK FRVSNGIIGL PYNVSQGVGC
QLRGQNCYVE VSLGFSRSGT DNSLQPNKIS ARNLPTLHVA ESPITGRSDH KGSADHLSDY
EKTFLYPTEA VLVPVLQTSL ARSSLRRFWL QNWMGPSLPS SSSFIQCAGN EDCCEDPWTE
INGARTQNSY DSSSNSNSSS ISSLSASSSD SDYKTTGPSE LEADADSLTC RQSMVSSADQ
LDSDGPKLGS KRSRTGVTES LSTATNIPVQ DTYMSDFGSV EVTNSAITGV GNEPIASYWD
WDDDDRGMEM DIQALLSEFG DFGDFFENDV LPFGEPPGTA ESQALMFSSP DYGDVNSSPG
GVIDVPDQIL LPVGFPSFES FNPPPSTSVE ECLNKSQDNL NNSMSLGPSN HSQMLYTREF
DHIMKAEAMM TFAAEFGAVE TPTCELSTTL FRSPYFPKCR KAESSNSSSN NYLYGSAPPS
SPCNEGSEGK NGMSVNTKTG SGKHDSSTSL LSKHYYTFVE SRKEKNDKNP VICNDNSIAK
SEGILPLSNI GSNAIVKSSL RKTAEGTHEP EHVLLSAKTL LATDITCVML QASVCRLRHT
LLSSGNLMTI GFSRSTGVSF LNQLPSDPNT ATDNISGKYD VKKKENIPIR IAGDIDGGML
DGHLNAPVGV WRTLGSSKVV KPSNSANMEV GSSFSHSSFN EEGILSYGQR KPLQELLDGI
ALLVQQALSF VDLALDADCG DGPYGLLAMQ EQWRRGFCCG PSMVHAGCGG TLASSHSLDI
AGLELVDPLS ADVHASTVIS LLQSDIKTAL KSAFSNLEGP LSITDWCKGC NPLVDTGSIV
DGVSVESTNN ECRDSSEPMS PSQSSVGGSS SIKVSNMMDG AKVDENSQRR SGHDLCSTES
EQQTCSRLKP TLIALPFPSI LVGYQDDWLK TSANSLQHWE KAPLEPYALQ KPITYHVVCP
DIDPLTSAAA DFFQQLGTVY ETCKLGTHSP QGLGNQMEIE SSKLSSCGFV LLDCPQSMKI
ESSNASLVGS VSDYFLSLSN GWDLTSYLKS LSKALRGLKI GSCFSTNPGE GSNSSCLVIY
VVCPFPDPTA ILQTVIESSV AIGSVVQQLD RERKSSLHSQ VVKALSGLAA VDEASPSNVL
VLSGFSIPKL VLQIVTVDAI FRVTSPSVSE LVILKETAFT VYCKARRISR GISSDFSQSA
FSGRSHSVLT QLPSPISGMW KDCVGPRMAG HSLPREGDID ASLRPGTWDN SWQPTRTGGL
SCDASRTGDI FLLDEIRYMF EPLFILAEPG SLESGISVIG SPTSESSKAL VDDSSGNYVQ
STSTAGSVES ASSTDGSGSD PKTPASLHCC YGWTEDWRWL VCIWTDSRGE LLDCNIFPFG
GISSRQDTKG LQCLFVQILQ QGCLIIQSCD PGLARPRDFV IARIGGFYEL EYLEWQKAIY
SVGVSEMKRW PLQLRKSMSD GLSATSNGSS LQQQDMSLIP ERTLPSSPSP LYSPHTKSTG
FMKGNLGQPS ARKQLMGGHS MVDNSRGLLH WAQSISFVAV SMDHTLQLVH PADSSTPGYI
EGFTPVKSLG STSSAYILIP SPSMRFLPPT VLQLPTCLTA ESPPLAHLLH SKGSALPLST
GFVVSKAVPS MRKDYRSNLK EEWPSILSVS LIDYYGGTNI PQEKVVRGIN KQAGRSLSWE
AKDFEIETHL VLESIAAELH ALSWMTVSPV YLERRTALPF HCDMVLRLRR LLHFADKELT
KQSEKS
//
