ID A0A0S4IM00_BODSA Unreviewed; 4428 AA.
AC A0A0S4IM00;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Dynein heavy chain, putative {ECO:0000313|EMBL:CUE71257.1};
GN ORFNames=BSAL_52975 {ECO:0000313|EMBL:CUE71257.1};
OS Bodo saltans (Flagellated protozoan).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Eubodonida; Bodonidae; Bodo.
OX NCBI_TaxID=75058 {ECO:0000313|EMBL:CUE71257.1, ECO:0000313|Proteomes:UP000051952};
RN [1] {ECO:0000313|Proteomes:UP000051952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lake Konstanz {ECO:0000313|Proteomes:UP000051952};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CYKH01000104; CUE71257.1; -; Genomic_DNA.
DR VEuPathDB; TriTrypDB:BSAL_52975; -.
DR OMA; EWERESK; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000051952; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF07728; AAA_5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000051952}.
FT DOMAIN 1003..1403
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1573..1899
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1934..2042
FT /note="ATPase dynein-related AAA"
FT /evidence="ECO:0000259|Pfam:PF07728"
FT DOMAIN 2083..2266
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2498..2579
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2636..2910
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2925..3053
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3078..3201
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3230..3448
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3762..3880
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3922..4072
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4080..4424
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3516..3538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3672..3699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3078..3168
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3392..3426
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 200..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4428 AA; 492119 MW; 2C67719B6929AD07 CRC64;
MIPNRPQSAP RAAQSANEAQ SRPSTARRPP QDPRTSSPRA TTPRSVVTRG GGTQEEFTQR
SIGNAIGGSL PNHSRSGTPG AQLVVSDGSA STYLTSLYDG EAHASNVKRF DVGRVPDIRS
VISSRPSSAK SAGLASTEPL HPKPPQAKGT SVRSPPPQAA VFDVNDNTYT FGTATAHLRA
MQGNKSTPSG PPTAPPHPPQ LSSSTVKSTP IVASAPQAST LDDDAALDSS AKDNSSDTSS
RPTTAKRPQS AKAAFEVKEA ANAMATTVHM STLQQLHRSG EPAAPNDKED MEKMKTFVDV
VSYYGRKKHA GTPTVKFVHM KRQPLVIGAT YRPYDLVVVP ADQCVNGEEH FVVSRTSVVQ
MLPAVPPVDG IGRDQQPAQL QTVAQFTQES ALFNIITKIR FFRLYLKQKM FSQWLKNIRV
KQFMSIRAKL AKRAFTAKKS YASPLRKLHQ ELASLQGPPL VNIPHVREGL SLDRFSSAMV
SQKMLVLDFY RTTMESAEHA INELIGNVQQ RADVPDFGSQ EALEQYVLFM EDQAAKRNGG
IYNPNAIPIT KRKEQMKRRL SELRGALEDQ QQLAHFLRLI DYIAAENMFY KALSSIRNLV
DEIAQSDNDR TLFFLIAVTF GEEGVLFVPA EDELLRVTSD AMDEIIASVV YLPRLITSAN
VKSVLEHASV TPKLHSMSIL LREDARVLAL RQSSKHRIEG DFCDGRDATN HFGRNKKWLA
FVNKTWPSML GDWNERLAVE NTTRDFLESR VGAVTNDEFT DVFRKGDEAF LNLKEMHAVR
RGCLVITSTV VLDFLMAKLR DITAECREKV LAVAKSRLDR VAATLNQRTK ALQERPTQLS
KFASFVSYVH DQVHDIAALN EACDQIEQLY IAAELNGCEP GQEAGRREVV LGRSQDHHHG
QSLRNRFEEA AHNAKDYVQG HSAEMGKKLM LELESESDNI ATFGTLVDSQ ILKVYSGDVV
DCLSFLTQLE ENISVSEAKL KTLLEWVKLF EVPASLEQHT SSLAEVKTQL KAKRELWLTI
GRFHEARSKC YTVPLSEADP QTYSKEIDEL YAKTYNRLNP RHQSDASERL LELLREEKLV
MGILIDLGNK NLKREHWAKI LSNQSRTFDA SMTLESLKHM KLFDAFYRDL IHEQSAVASG
EATLLSSLEE IKTKWGATQF STKPFRDIKD QYILDDVSEI IQQVEEHQLL IQSCLASRFV
TGVRPQIEDW ERKLHLLTLV LDEWIVVQNS WMYLAYIFAG EDMKRQLPTE TAMFKHVNNS
VKELVNRAHN FKNCIVVATD APILETLKGA RTSLDVIQKK LEEYLETKRA VFPRFYFLSN
DELLSILSDV RNPRAVRPHL RKCFDSINDL VFKQDSQTDI TGVVSVEGEV LSFLNIVAAR
GGVENWLGAV EQAVNASLKA NMTSTLNALA PEDGSRRQWY LNVQQGEGHT VNLKANPNAS
TGKLTSVTSM NGGHPAQCIQ AIDAVQWTVE VEEAIARTAS GESPKALEQQ YAAYRAQLSD
TVKTVRLSLT PLQRSLIQTI LVLSVHNRDV IKELVDQKVS DSDDFAWRKH LRSYYSHETQ
LVYIEQVRAK LAYCYEYLGS AKRLVITPLT DRAFLTCTQA LHLNLGAAPQ GPAGTGKTES
VKDLGKALAR HVVVFNCSDG INTAMMSRMF SGLAQAGSWA CFDEFNRIEL EVLSVVAQQM
LEITSAVSQR LTRMTFDGHE LALNPHFGVF ITMNPGYAGR TELPDNLQAL FRPVCMMIPD
YRLIAEIMFF SEGFLNAQSL SVKMVQLYKL SSEQLSKQDH YDFGMRAVKS ILVTAGSLKR
AEPNADEDML LIRAMRASNL PKFLREDANL FLAIIKDLYP SLEIEASPQQ GLSEEIERQT
LAKDLVISST FTDKTLQLFD IIVARFGVML VGPTLASKTT SSLVLEQALS SLATSAAVNS
KGHHPHYAPT TRFTVNPKAL SRQELYGSVN VTTREWVDGI LSHMVRSVCS AASVSEAAPH
RSWVTFDGPV DALWIENLNT VLDDNKMLCL VNGERIKLPD SVTFLFEVQD LRAASPATVS
RCGMVYYDSS VVDWKQQLQN LGQALAKKYS ANEVWKQDVF DRVTDALIGP ALEFLEENGK
EWIPTSHSHR IHNIMKLLDA ALAQCEDNDD DPAPTVLPPP EVDEDGQELP ADGVIVEMER
PNGGAKFAAV HALSDSEAPR RLFEMTVIFA VIWGIGGNLC DDAKANARNR FSQFIKEKIL
DVDDTFPQSS SNVAGGTGAV IIDSGAPFGV FDVFPHKGSL QWVDWAHKVP EFLYRRRQPF
GEILVATPQT VSSSHIVSSL VKGCHAVLIN GTTGTGKSVG VQQSVLTEVL HTDDAQSNYQ
SFTFVMSAQS SGHQLQELLE AHLRKHPSKL KDQLHIGPST GKTMVMVIDD INMPSTDEYG
ACPTLELLRQ ILVQGGMYDT KRCMFKNVSN VVTVACCGPP GGNRTELSPR LTSQFFTLCQ
PQLGDTSVQR IFGSILQGFL STFNGDVRGL STGIARATID VFKKVAAELL PTPERAHYVF
NMRDIGRVVQ GVTQSSPSEY LVRNDMLRLW VHECFRVFCD RLISSSDRSR FRSIIGDVFV
NRFHAAMPMD WDDSLYSDFT SLAEVPVYRP IELGKGLEDV LAQKLREYAV QHNKDLDLVM
FDDAVRHLCR LCRVLRQARG NALLVGIHGC GRQSLAQLAA FLCRCKRYQI QLTSAYDHVD
FRKDIRNVLK MAGGDNEPVA FILTDSQIVK EVFLEDVNSL LNTGEITNLW EPDDLDGIIA
STRERVRRLK KPETVASMLA TFVTSCRDNL HIVLTMNPMG AALFRRLRTF PSLLNCMTID
WYDPWPAKAL HSVANKMLSE ALVAASATST SATSESLYEE DLGRISDLCE FFVYVHTTVE
KACIDFDRET RRKAYCTPTS YIGLLQSFAA MLRDQREASE ESILRFQTGL ERILDANRRV
DDMKNALIRL QPELETSTTE TQVFAAQVER ESKAAAEIAQ GVAKEEAQCA LMMREAQAIK
DECQAELDKA MPAYNEALDA LNSLNIKDIQ ETKAYTSPPK KVEMVMDAVL TVIEEAIGWE
NAKKVLGRSE FVTYLILLQP KQEKLAKAEA ALEKAKATLA KKQAELAELE ARLKKLKQQY
DDSMARLKQL EADKARTELH LARAAKLLSG LTSEHERWTK SIAELEAKSQ HAMALTALAS
AFVAYAGVFD AHYRDTLVQK WIVKCQAVGI PMDTSKPFRV QDVIDPVMVR HWNSQGLPIA
DFSTQNATIV SKSTRWCLCV DPHHQANGWI KNAYKAQGLI VLRMNDPNLT RHLESAVRGG
HAVLIEDVET NMDASLDPVL RRETFRSGGR LMITVRDQPI EYNPSFFLIM TSRIANPHFL
PEVHVKTTVI NFDVTVKGLE DQLLSEVVRC EKRELEDRAD QLFMQVSDAR QQLKSIEDQI
LSLLANSGAN LLENDLLITT LHQSKQTGIE LTEGLAVIEG TSVQIQDARE VYRPIATRGA
IIFSVIQHVS RLDHMYQTSL HAFIQQFRRT MIMTPTEDDG ADNNKKQGEL ENTSFTSSYD
PIKAPRTPSI IGRESAVEER ERLVRRRTLL IQNITLNSYQ FVTRSLFEVD RGVFRFLMAA
SIARSTGAIT DAEWSYFLCE SGGTLPQQLK DLPGEWMPDT NWENLLYLSE AIPAFRTLAD
SIATNEGEQW STLRNNPFVN PDGDENSDAA SPEGSPRSPT AVFTLPPMFV AMSLWHRMIL
LRTLNSSALG NMAKKFVEVE LGRVYNEVPA FDLGSAFAQS NPSTPICFLL TPGTDPTITF
SRFAERNGMA TKTTMISLGQ GQGSRAEAAV HKAMVGGQWV FLQNCHVYAS WLPQLAHLLE
SVQAQVASGE GVHSEFRLWL STLPCSDFPI SVLQSAIKLT REPPRGVKAN LRDSLALTVE
HDAWRAAPSS ATGGGSQQLL QWRKFLVAFS ITHAILQERR KFGPVGWNVP YSWSLIDLEN
TLRISQGLCE NEPLMPNHLT GNIDFSSWDA IYHLIGDICY GGRVTDLWDS RTLRCIVERV
VNPSTFGPGG MSLTEDGRYR VPSQFDSDSL MLFVEKLPGF DPPELFGLHP NAEIRVKELE
SQHLLKSLVL IQPPTTTTTS GASSSKNGAS DASSSSITVV NEVIARLPVD IDADPNADVF
VRGNDGVLTP LGNVCSQECQ RYNTLLKALR SQLVSCLRAL KGSIALNDSL TSIMQSLSFG
QVPHAWESMA YPSMKSLYSW VTDLNARVDF FRDWVDGGAP QTFWLGGFTF PQGFVAAVLQ
THCRRYAIPV DALTVASFPT ADVDPLEALL EPLATGVYLH GLTLEGARWN VAEKCLDELI
GKNMQSVMPI VALIPVLKPN LTPQPSTGGS DPSTSQREID AQNALIPALT SEEVFECPVY
KIGTRAGSLS TTGISSNFIL SLSLNAGQVH TPNHWIERGC ALLTSTGN
//
