ID   A0A0S4J2H7_BODSA        Unreviewed;       285 AA.
AC   A0A0S4J2H7;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Aldo-keto reductase, putative {ECO:0000313|EMBL:CUG58400.1};
GN   ORFNames=BSAL_81680 {ECO:0000313|EMBL:CUG58400.1};
OS   Bodo saltans (Flagellated protozoan).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Eubodonida; Bodonidae; Bodo.
OX   NCBI_TaxID=75058 {ECO:0000313|EMBL:CUG58400.1, ECO:0000313|Proteomes:UP000051952};
RN   [1] {ECO:0000313|Proteomes:UP000051952}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lake Konstanz {ECO:0000313|Proteomes:UP000051952};
RG   Pathogen Informatics;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CYKH01000886; CUG58400.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0S4J2H7; -.
DR   VEuPathDB; TriTrypDB:BSAL_81680; -.
DR   OMA; WPPFLYD; -.
DR   OrthoDB; 5305445at2759; -.
DR   Proteomes; UP000051952; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd19071; AKR_AKR1-5-like; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 2.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000051952}.
FT   DOMAIN          53..198
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   DOMAIN          205..265
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   BINDING         115
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            82
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   285 AA;  31481 MW;  96D1F9AED9474BC7 CRC64;
     MAAIRSLPLS QGPKPIPTFG LGTFRAEGND CHESCLAALP RPMADNLCRR EIENEDQVGT
     SIEAFLAEQT EVTRDDLFIV TKLHWDSHGG DKAVAKVEES LKKLKLAYVD LFLMHSPKGN
     KVVETYKGLL EAKARGLIRA LGVSNFGKEQ LIELLATGVE VPAVNQIELH VWNQQRDLTY
     FCQQKNIVVM AFCPLARGDK FGKTRLTAIA ERLGTSEATL CNYWVLKSGF VTIPKSVKPS
     RITGNLEVLE IRLSANDVAE LDTLEEAFEC SLAVAAQRIP WSEVA
//