ID A0A0S4JCE3_BODSA Unreviewed; 4270 AA.
AC A0A0S4JCE3;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Dynein heavy chain, putative {ECO:0000313|EMBL:CUG85918.1};
GN ORFNames=BSAL_91085 {ECO:0000313|EMBL:CUG85918.1};
OS Bodo saltans (Flagellated protozoan).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Eubodonida; Bodonidae; Bodo.
OX NCBI_TaxID=75058 {ECO:0000313|EMBL:CUG85918.1, ECO:0000313|Proteomes:UP000051952};
RN [1] {ECO:0000313|Proteomes:UP000051952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lake Konstanz {ECO:0000313|Proteomes:UP000051952};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CYKH01001210; CUG85918.1; -; Genomic_DNA.
DR VEuPathDB; TriTrypDB:BSAL_91085; -.
DR OMA; CIEWQRY; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000051952; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000051952}.
FT DOMAIN 1588..1727
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2221..2370
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 591..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 944..1004
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3087..3121
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3363..3390
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 591..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4270 AA; 488305 MW; 6ADFA537B6B4B256 CRC64;
MSGERTIKDL VEVVPEALLE GKTEKEKFEI SRGFRALARL KEQEAGLTTQ AYLKSAPAEQ
KIPKPQRRIP QTGHSKSIVK VNVPKALVNL RRDKSAVITT SSGLSPKRLA RDEFGTVHID
PRSDLATVEM KGSIKNASPS ERIALLYTPT ANVRTTGRND VMCAYEYQIS YRNVDVPPPP
QDEASKASGA GVAGKDPALS HFLPLDEFDN LEFELHAPQA WIELGTECGG TPARSKYHTE
SDGDVWTACR VTSYDETTNA FRITWNHNGK QKWVKRLNLI FEEEDELMWQ ERVAQAEELR
QVAETNIRLH LYVESIDDNV ITPVDEDQVD RILGLVAGEF PLHHLHVVEE CIAEMRHMYS
VGLKKAVHNY HFRNPVEQKR LGPLCLPAPD ADPIHSLNRL LGTIDTPSPN FLGARTYVGE
NLFTTHALLY DTLLAINVRW RQFENGLLCD TKLKGIALPC ELHIFEDSQN KCGSFVSERL
REDWSSNVNT TIQNDLDTHF NFYEESMERF VESRMFRFFR MVNIAMSSQL RQLLVATITS
YTDFLQRYKV VFPEGFDQQA DIVEELGTDT KEREYWEQKA ADILERRAKE KALREAAKPQ
ERKKKKPVAE VNPDNDESVR PAGEEGAPEE PSALEFPFVR NEIPYSRCIV DKTQNPNGLR
PLFVIRLISN GDSVMFSPLL EEVEDKVKGV FDNFFTYSDN IKGIGDQLFP LLALPPVILK
PLDQQEVTVV ACKEAIHEVI ASNMEGPLQL QRMYQPFEYI LKTEIDELVE SFTTRKPAPT
LDDFDVTLER LRRDMERIRS RTLNEVKFEL IRVECEGVKN SLLGKAYNIM RSIMDLLAQQ
LADDTQTVSA GYKNIFTRVG FEPTTPEELQ ELKNFIDTVP DQMTKLTEMF QRITEGNDIF
LKYKYLTQYD DFVGYWDAFE WPRKVQQQLE DSEFRLKEYR NTFQTELREN CEQLSEDINT
LAAQVETFSR VGDDARADEY YEHAKMLDKK LKQYQADIIK YNSREQLFGL PTTQWAHIKE
IKTAFEPYYH LWEVASNFNA ESERWQSALI TALTPKDIDN QVTEWSKKMA VVSKKIKEEA
PAEVVRKVRE NIERFKPLIP LIYALRSNLQ ASHWKNIFQI CGVDQGKGQQ QPGSEVKPLN
EYIKMGMLDH IIQIESIATT AKKTFELESE LTGMENEWKK LCFEMEPYLD TFKLKASEIM
QQVLDENILK TQSILSKPIL RQAQNVQTRA FLWAKQLDNI QNTLDEWFKC QNTWAYLEPI
FSSADIARSL PHEKGMFTVI DEAWHKIMDV TRQTPQVIAR CQDETLLKTL SESNINLEHI
LRKLQQFLET KRMSFPRFYF ISNEELLQIL SNSKDPYLVQ PYLAKCFEGI KRIHFQDSLD
ITAMESPEGE VVQFCKKVNP TDHNNMVELW LGAVEEVMAE SIRDHLRRSR EDYPNRKRTE
FIRHWPGQIV IAICSVYWTM EATEAMVSDA TGLQGYAEKC TAQLDDLILL VRDRDLKHVE
RCTLEALVVI EVHARDIIIE LADKGIDNPN AFDWLAQLRY YWEDGNLDVR QINASLRYGY
EYLGNTGRLV ITQLTDRCYR TLMGALHLNY GGAPEGPAGT GKTETTKDLA KALGKYCVVY
NCSDQITSKD MAKLFKGLSQ SGSWGCFDEF NRIEVQVLSV IAQQVATIQD AIALKKTEFI
FEGAQIRLKH GTAVFITMNP GYAGRAELPD NLKALFRPVA MMVPNYAMIG QIQLYSYGFL
IGKVLAEKIV ATYRLCSEQL SSQDHYDYGM RAVKAVLTAA GRLKRQYPDE DEMILMLRSI
QDVNLPKFLA QDVELFKGII SDLFPGVTLP APDYGAMRKA LSTVCDEMNL QLTEYFDLKV
FQTYEMIVVR HGMMLVGLSF GGKTKVLQSL SKALGLMKLQ KLEEKTRLIT MNPKAITMGQ
LYGKVDQSGE WNDGVLSNAF RSAGVDTTPD RKWLVLDGPV DAVWIENMNT VLDDNKKLCL
QNGDIIPMSK SMNMIFEVQD LSHASPATVS RCGMVYVEPD TLGWQCLMDS YLNTVPEFVT
SNETYMTCLK GLIEHFMQPM LEVVRKNTAT AIPQGGSVSV ASFIKLFNTF IKEFDFSETG
PREYEDKDVI ARLEGWFLFS LTWSVGGCLY NKDRITFNTH LVDLINTVAN KDGFKITLPL
PENKRTFYDV CFEWTKECRF VDWLDTIPDF HIPEGSEYQE IIVPTADTAK YTYLVNTFIA
NMCPALLVGD TGTGKTIMMK AILTLLPKET YPLNMIQFSA QTSANDAQKM LDNRCEKRRK
GVYGPPIAKK MMVFIDDVNM PQLEEYGAQP PIELLRQFLD HGGWYNHTKD NVDFREVVDL
LFLCAMGPPG GGRNPITQRF TRHFNSIAVP SFDESTLKKI FGTLMDWILT RGFNAGLRSL
SLGIVSATVE VYETLVERLK PTPEKSHYTF NLRDVSKVFQ GISMVNPNRI QDQRKLYMLW
THEVFRAFAD RFIDRKDTEW FINELDPLMQ KHFKMGYRSV VPTDEPTLFT DFMNEQGLYE
EVEDIAEARK MLEDKLDLFN SSPAVRAGRM DLVVFNYVIE HVARICRVLK QPSGNVLLVG
VGGSGRHSCT RLAAYLQEYE YLTVTMTKDY KRSDFHDDIR QILLKTGQNG FPVAFTLADT
QITDETFLED VSNLLNTGEV PGIWDSKQDK DTLENAAASL REVAKELGRP DSAESFLQLF
VERCKKYLHI VLCFSPVGKT LRDRLRKFPS LVNCTTIDWF REWPEEGLRN VATRFLDDLD
LTPDLRVSIR ECFVKYHTQV RELGVQYLEE ARQNTYVTPT SYLELLGTFS ALLEKKRNEL
TKMRQRYDGG LDQLRKTEES VEVMKQELAL MQPELVKKQK ITDDLIVEVE KESKIAEAQR
ALVAVDEAAA NETAAAAKKI KDVSQAQVDE AQPLVEQAEK AVQDLDPKQL QEVKALKAPP
QGVKFVIEVV MTLLGGTYKP KPQRDPQTGK TFLPYWDHAK SVLLTGEFKN ILLQAYPVIV
DSAPEEQIEE VKEKMKDDMF KPESIKKTSI ALVGVAAYVR AVVEYYKQNK IIKPLVAQAA
VAQKEYDVAM ASLKVKKEEL RIVDEKLAKL TGHLDQVKAD KQSLEDKVAD TDTKLTRAKK
LIEGLGGEKA RYLQESKRFA EAYKYVVGDV VVSAGIVAYL GPFQNKYRQK TVVTWLEMCK
EKKILGSNDF VFEKFLGNPI SIQDWKIQQL PSDSFSVDNA IIMTNSSRYP LLVDPQQQAN
KWIRNMEGSR LVVVRPTDDG YTRKIAVAVR EGRPCLLENV LEDVDPMLEN VLLKRLVKEG
TSYTVMIDEA VEWNANFKLY ITTKLPRPHY RPEVSTKVNL INFMITPQGL QDQLLQEVML
SERREVEEKK NKMTLEAAEN KARLKQTEDT ILAILSAEGN ILDSETAIQE LDSAKIQSDK
SAKRQEEIDA MEKVSNRTRM QFVPAAQHGA ALFFCVTELA NIDPMYQYSL QFYIALFKIG
LLESEKCEEV EERIQNIRST FQSSLYVKIC RSLFAKDQLL FSFIMCLKLF DVDPAEVRWL
LMGGFEQDKG LTANPFPFLP DLAWKYAWRA STQLANFKGF TDVLAQNEDW VRDFYESTEP
LSIQTPPAME KYKDLQWLIV VRCLRTDKIV PAVTSFVQGK LGNFYVEPPF VNLENIVEEI
PDPTTAVIFV LSPGADPNAE LDRVAEIKGM LGKKLFKLSL GQGQDVPARE LIDDGKRQGN
WVLLQNCHLY KDFMPDLARI IEDYSRDAVK ESVHRDFRLW LTSLPSEDFP VAILQNGVKL
VQEPPKGLKA NLQRSYLSDP IADAKFFYSC NKPEPWRKML FGLCFFHSLV QERRKFGPLG
WNRPYEFNDT DMRISVRQLH MFINDNAEVP YEALTYLTGH CNYGGRVTDD WDRRCLMATL
AVFFSSTILE DDYLFSNDTP EYFAPPHGEH ESYVTYIQGL PMDQKPGIFG LHSNADITKD
DRDARLLMDA TLATQPRESS GGGGSALDPK AIVLQIAKEV HAKLPKLFDT EDIQAKYPIL
YNQSMNTVLL QECIRYNRLL AIVRKSLSEV QRAIKGEVVM SNDLEQVFNA IYDSKIPDGW
RKRSYPSLKP FGSYINDLLD RLNFLQKWID NGPPPTFWLS GFFFTQSFLT GVMQNYARKK
HIEIDKLVWN FTVMHEPDYD TAPEDGCLIH GFYLEGAGWD HENKRLCESK PKELFVKFPI
LLLTPCRPEE VDTSPSYACP AYKTTDRRGV LSTTGHSTNF IMVMTLPRHP ADSENHWVMR
GTALFTSLEF
//
