ID A0A0S4JPL1_BODSA Unreviewed; 1048 AA.
AC A0A0S4JPL1;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=WD40 repeat-containing protein, putative {ECO:0000313|EMBL:CUG93449.1};
GN ORFNames=BSAL_42935 {ECO:0000313|EMBL:CUG93449.1};
OS Bodo saltans (Flagellated protozoan).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Eubodonida; Bodonidae; Bodo.
OX NCBI_TaxID=75058 {ECO:0000313|EMBL:CUG93449.1, ECO:0000313|Proteomes:UP000051952};
RN [1] {ECO:0000313|Proteomes:UP000051952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lake Konstanz {ECO:0000313|Proteomes:UP000051952};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CYKH01002155; CUG93449.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S4JPL1; -.
DR VEuPathDB; TriTrypDB:BSAL_42935; -.
DR OrthoDB; 56358at2759; -.
DR Proteomes; UP000051952; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR039241; Rrp9-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19865; U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR19865:SF0; U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000051952};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 384..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 839..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 66..107
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 108..151
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 152..191
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 192..223
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 432..637
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 658..873
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 1048 AA; 118827 MW; E6C1080B5C05C493 CRC64;
MDLRFMQYNS EFDENEEKST PIVTWMEKER IFCMAATPGG RIITAGDTSG DISFWDSRTG
TKEYDLSGHT EAVLALVVVA DLNALFSAGA DSTVRLWNLE TLQNTMVFEG HRGFIVGLFA
MRSETGTGLF SGSDDRTVKQ WNSNSGACVH TYKGHKGPVN AITATETNMI SGSSDGIIKI
WDLGSRRCIR TIEAHTDSIW CLIQLKDGRF ASGSTDSSIK IWENIFLNNN AVTLTAHHGK
VRKLLSYGPI LFSAGADAVI YAWDTRTNNL VRTLKYHTKQ ISGLTLHNNN LCSSGFDKNV
CRWDVQLLLP EKQPIVQFQQ LSVAKDQDGD GGDKNEGVNY RRNQKRVREK TPEDIVELYK
ELPINFVVDA LDFKVTSSRL MGEIIFYIPF LICFVFVFML ARPIEDGYYM TQAISDVLVT
QQLPSFKNPR TFTEVTTVAW FYTWMTLMVT ELWRDRSDLT FPSVQGQNIL VGAMRVRQQR
ATPNSCSFNK HFFNMSVGGL PCYGALDSQG DTSPFVCPQY SLCSNTTTDN ANAIAAALST
LGLTSAGFTF DASAGLPYEG QVASYTDGGF AIDFNFSEPL QVQLDKIAAM ETLGYVDEVV
TRLVDVAFYV YNPSIDVFVS FLMVLEVPYG GTWMPLARTT GFEVFTTRHS GQLGFQVFFF
FFVLGFIALF IWQFVADFRK GRTTSFILDA WNVIEFVNLL IFIVMYGYLY SWIIQSRQLK
LDDLLAETAY SSILEKTNTY YQSMVWFNAV NTVLTFMKLL KYVRLNDRLN ILTRTLSVAQ
QSLLGVLVLF VYVVFGFALT GNNLYGVAMF NFRNISVSYV ALLRALIGDV DYTAMTMETI
IVTIFFFWAY MILGQFILLN FLVAVISDGF HEVSMTKSSI PLDQTIVKAF KDARYEFLPK
VLRWKFLLLR HRATQTTIVA NTLDELVDKR NKMVDEDAAQ RQDYDEVEDV LMRKADFKAL
VPKDDQELLK ENETFIDEVW KDMAWEYHHK QMAAKGQDEI EREAIVFEEV EQALRGLSAS
FPVMEQLKNR LQVQEAKLRP LARSMGIR
//
