ID A0A0S4KNK6_9BACT Unreviewed; 684 AA.
AC A0A0S4KNK6;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=NITINOP_0968 {ECO:0000313|EMBL:CUQ65943.1};
OS Candidatus Nitrospira inopinata.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=1715989 {ECO:0000313|EMBL:CUQ65943.1, ECO:0000313|Proteomes:UP000066284};
RN [1] {ECO:0000313|Proteomes:UP000066284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Daims H.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; LN885086; CUQ65943.1; -; Genomic_DNA.
DR RefSeq; WP_062483653.1; NZ_LN885086.1.
DR AlphaFoldDB; A0A0S4KNK6; -.
DR STRING; 1715989.NITINOP_0968; -.
DR REBASE; 132199; M.NspENR4ORF968P.
DR KEGG; nio:NITINOP_0968; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000066284; Chromosome 1.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000066284};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..140
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 152..456
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT REGION 576..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 78183 MW; D75545F41A0E0405 CRC64;
MNNFGEKVSF IWNVADLIRD TFKRGKYQDV ILPFTVLRRI DCVLAPTKEK VLEENAKLKA
KKLENPAPRL CKVSGYAFYN TSRYDFDKLL ADAPNLAANL RNYINGFSPN MKEVLEKFDF
DNTIKKLDEA GLLFQVMERF KTIDLHPDKV SNHEMGYIFE ELIRKFNEAL DENPGEHFTP
REVIRLMVNL LLAQDKDVLA KNHIVRTVAD PCCGSGGMLT IAKERILEIN PHADVYLFGQ
EVNPETWAVS KADMLMTSPD GRDAENIAFG SVLSNDKHAD KQFDYLLANP PYGKDWKRDQ
EAVEAEHERG HAGRFGAGLP RISDGQLLFL QHMLNRMKDT KDGGSRVAII MNGSPLFTGD
AGSGESEIRR WILENDWLEA LIAMPEQLFY NTGIATYVWV LTNRKERKRR GKVQLINASS
FWVPMRRSLG DKRREISAEQ IQQITDLFTA FREGEHCKIF NTTDFGYRKI TVECPLRLNF
QASPERIARL NEQTALKNLA VSKKKHAKER VKEEEEGRKK QGAILAMLQT LPSTLFKDRA
RFIEELDKAQ EKVDLKLSKS LREAILNALS ERDETAEICR DEDGNPEPDP ELRDTENVPL
KEDIQAYFDR EVKPHVQDAW INRAVVDHKD GQVGKVGYEI NFNRYFYTYQ PPRPLEDIEA
DIRSIEQDIV HILGELTGGG CAGA
//
