ID A0A0S4L1R5_9BACT Unreviewed; 698 AA.
AC A0A0S4L1R5;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=COMA2_10208 {ECO:0000313|EMBL:CUS31628.1};
OS Candidatus Nitrospira nitrificans.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=1742973 {ECO:0000313|EMBL:CUS31628.1, ECO:0000313|Proteomes:UP000198736};
RN [1] {ECO:0000313|Proteomes:UP000198736}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Luecker S., Luecker S.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CZPZ01000001; CUS31628.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S4L1R5; -.
DR STRING; 1742973.COMA2_10208; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000198736; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:CUS31628.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198736};
KW Transferase {ECO:0000313|EMBL:CUS31628.1}.
FT DOMAIN 12..135
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 153..434
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 698 AA; 79028 MW; 76C58F8113552677 CRC64;
MTINQLAHIE QLEANLWDAA DNLRANSKLT AGEYCMPVLG VIFLRHATNR YAEALREIQA
EQATGKIPKR PLTAADFKKR RALLLPKEAH YDELLKLPKG SDLGTALVEA MNAIERDFEP
LQGQLPKDYT KFENTLLEDL LRVFDSETLR STSGDIFGRI NEYFLMKFAM QGAQDNGEFF
TPPSLVQTIV NVIEPDHGTV FDPACGSGGM FVQSSHFIER RGESAAHRVT FYGQEYKTSN
LRLAKMNLAV HALEGNIVEA NTFYEDPHRL PEGKPLWGNC DFLMANPPFN VDKVDAEKAK
VDRRLPFGLP GVNKDKKVSN GNYLWISYFW SYLNKTGRAG FVMSSQASSA GHGEMDVRRK
LVETGGVDVM ISIRSNFFYT RTVPCELWHF DRGKPVDRRD QVLMIDARNI YRKVTRKIYD
FSPEQLQNLT AIVWLYRGQS DRFIALVQHY LERTLTEAAA IVGKSADYRT AYGALTNAVA
PFIKTVPKDS PIRELVKERD DAAKNCFQGL EYLTKRIAKD WKKPGEPKLA AQKKLLGELE
DLATACRDLV KDVDLAFKLD TRLVDMAEKD FNAKEHEAWD GRAIGRLEKE LDARRKEAVE
QLKAAAYFER QAHWLLSRFP DAKLVAVPGL VKLVDRKDIK AADWSLTPGR YVGVAPPEVD
ENFDFEQALA DIHIELTDLT QEAAVLAKKI QRNFEELA
//
