ID   A0A0S4L3S4_9BACT        Unreviewed;       480 AA.
AC   A0A0S4L3S4;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=NAD-dependent malic enzyme {ECO:0000313|EMBL:CUS31370.1};
DE            EC=1.1.1.38 {ECO:0000313|EMBL:CUS31370.1};
GN   ORFNames=COMA2_10066 {ECO:0000313|EMBL:CUS31370.1};
OS   Candidatus Nitrospira nitrificans.
OC   Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC   Nitrospira.
OX   NCBI_TaxID=1742973 {ECO:0000313|EMBL:CUS31370.1, ECO:0000313|Proteomes:UP000198736};
RN   [1] {ECO:0000313|Proteomes:UP000198736}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Luecker S., Luecker S.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   EMBL; CZPZ01000001; CUS31370.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0S4L3S4; -.
DR   STRING; 1742973.COMA2_10066; -.
DR   OrthoDB; 9805787at2; -.
DR   Proteomes; UP000198736; Unassembled WGS sequence.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR   CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR   PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51671; ACT; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:CUS31370.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198736}.
FT   DOMAIN          13..87
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   480 AA;  51077 MW;  4399708E02CA7944 CRC64;
     MRDVGPYSNY RLTVRLELAN KPGIFAGVAA LLAEEQANLG AVDLVSATKT RMVRDITFDV
     QNEEHGEKVL ARLGELPDVT VLSASDRIFL LHLGGKIRVG SKFPISTRNV LSMVYTPGVG
     RVAQAIAKDR SKVYTFTSKS NSVAVVSDGS AVLGLGNLGP EAALPVMEGK VMLFKELANI
     DAWPICVNTQ EPDEIVRIVQ GIAPGFGGIN LEDISAPRCF EIERKLKQSL DIPVMHDDQH
     GTAVVLLAAL TNALRVTGKP LDQVRIVVNG LGAAGTACCR MLLAAGAAHV LGCDKEGIIL
     YGEAEQLRAC RSDLRACFTR DHPKGTFRDA LKGADVFIGL SVGNVVTADD LELMAPERIV
     FALANPDPEV PPELGTAHST IFATGRSDYP NQINNALAFP GIFRGALDVQ AGEINEAMKL
     AAAQAIAHVI PEGTLSEDYI IPSVFDKEVV PCVARAVAAA ARASGVARRR AKADDSPIFE
//