ID   A0A0S4LAZ2_9BACT        Unreviewed;       518 AA.
AC   A0A0S4LAZ2;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=HD-GYP domain-containing protein {ECO:0000259|PROSITE:PS51832};
GN   ORFNames=COMA2_120025 {ECO:0000313|EMBL:CUS33019.1};
OS   Candidatus Nitrospira nitrificans.
OC   Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC   Nitrospira.
OX   NCBI_TaxID=1742973 {ECO:0000313|EMBL:CUS33019.1, ECO:0000313|Proteomes:UP000198736};
RN   [1] {ECO:0000313|Proteomes:UP000198736}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Luecker S., Luecker S.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CZPZ01000004; CUS33019.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0S4LAZ2; -.
DR   STRING; 1742973.COMA2_120025; -.
DR   Proteomes; UP000198736; Unassembled WGS sequence.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1.
DR   PANTHER; PTHR43155:SF9; METAL DEPENDENT PHOSPHOHYDROLASE-RELATED; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198736}.
FT   DOMAIN          246..446
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  57487 MW;  4C09705CE9503256 CRC64;
     MIVKEGQSQS LGNPPTHDQS QPLLTHEKSL SRKIGQGSEA GDILDQQLVM LGFQLITQLN
     TLIKTSKIHG RANAALDKPV ETMLTLIETL AHDRPVTLWV QDDFLFLGEN HLKVTAQQML
     VVSSILDALK KWKIGGLTFA SSVSSKDLRE FAHLFVTLDP ATKSIEDFRR ELSNLAVAGI
     ELNDPRLLNL KEDLPENRNS KTHHKARSKT AYGKAADAVG NLTQSSRDGK ALNFKQAKRA
     IQNIVDLMMQ DESIMLGLTT LRCHDQYTHN HSVNVSLLSI ALANRAGYPK VELADLGLAA
     LFHDMGKSTI PLEVLNKPGE FTEDEWTMMR NHPTEGVLSL TQLRGITNLP ARMAAASFEH
     HMNLDYSGYP KLKTPWKLSL TGRILTIADC YDAMTSSRVY RREPMSPSKV LTMMLAKSGK
     SFDATLLKLF VNCVGIIPIG SLVVLDSDEF AVVLKPAADT TESERPVVKV ITDAEGTPIE
     HGPELDLTEK DDTGEYRHSI IRLVDNTEHK FDTSRYFV
//