ID A0A0S4LBX9_9BACT Unreviewed; 581 AA.
AC A0A0S4LBX9;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=lipopolysaccharide heptosyltransferase II {ECO:0000256|ARBA:ARBA00044042};
DE EC=2.4.99.24 {ECO:0000256|ARBA:ARBA00044042};
GN Name=gmhB {ECO:0000313|EMBL:CUS35191.1};
GN ORFNames=COMA1_20165 {ECO:0000313|EMBL:CUS35191.1};
OS Candidatus Nitrospira nitrosa.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=1742972 {ECO:0000313|EMBL:CUS35191.1, ECO:0000313|Proteomes:UP000199032};
RN [1] {ECO:0000313|EMBL:CUS35191.1, ECO:0000313|Proteomes:UP000199032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COMA1 {ECO:0000313|EMBL:CUS35191.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-
CC [alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-
CC (1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid
CC A + H(+); Xref=Rhea:RHEA:74071, ChEBI:CHEBI:15378, ChEBI:CHEBI:61506,
CC ChEBI:CHEBI:193068, ChEBI:CHEBI:193069, ChEBI:CHEBI:456216;
CC EC=2.4.99.24; Evidence={ECO:0000256|ARBA:ARBA00043830};
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
CC {ECO:0000256|ARBA:ARBA00043995}.
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DR EMBL; CZQA01000008; CUS35191.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S4LBX9; -.
DR STRING; 1742972.COMA1_20165; -.
DR Proteomes; UP000199032; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR CDD; cd07503; HAD_HisB-N; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006549; HAD-SF_hydro_IIIA.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006543; Histidinol-phos.
DR InterPro; IPR011910; RfaF.
DR NCBIfam; TIGR01662; HAD-SF-IIIA; 1.
DR NCBIfam; TIGR02195; heptsyl_trn_II; 1.
DR NCBIfam; TIGR01656; Histidinol-ppas; 1.
DR PANTHER; PTHR30160:SF7; ADP-HEPTOSE--LPS HEPTOSYLTRANSFERASE 2; 1.
DR PANTHER; PTHR30160; TETRAACYLDISACCHARIDE 4'-KINASE-RELATED; 1.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR Pfam; PF13242; Hydrolase_like; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:CUS35191.1}; Hydrolase {ECO:0000313|EMBL:CUS35191.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199032};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CUS35191.1}.
SQ SEQUENCE 581 AA; 63246 MW; D0B702EBE6CCDD9A CRC64;
MGLYREAVTQ RSVMLETQPR KILLRAPNWI GDAVMCEPAL RGLRSLFPEA EVTMLAKSAV
AELFRAAPEL NRVLVYEDKG AHAGLSGKWA LAGLLRRHGF DLAVLFQNAF EAAFLAWLAG
IHQRYGYATD GRVFFLTNPV AVVEPRQSVH QVEYYWNLLK PLGLSGGAPK PTLHVTAEES
HALDARLETL GTGVSDIVIG INPGSTYGSA KRWLPERFAE VASRLAAQVG RDEGRQVLVA
ILGAKGEESL GQDIASRING RTVVLSGATT IRELMAVVKR CRLLITNDTG PMHVAAACGV
PVLAVFGPTD SRTTSPYGQE QSVVREAVDC APCLLRECPI DHRCMTRISV DRVYEAALRQ
VSRLGVTGEG QAKNSSSALH ASHLMPNRLL EGYTIFLDRD GTLNPDPGYI NSPDQFELFP
GVAEALGRLK LAGARLILVT NQSGIARGLL SRQHLDAIHR KLAYLLGQAG TTLDGIYFCP
HHPDDGCGCR KPNRGMIDQA VQEQEVDLKQ SYVIGDHLRD VELAKRVGAR SVLVTTGATR
LQDVEGLTDT QLIPDRVEAS LTEAVDWLLS DVKRGALSQH E
//
