ID A0A0S4LHJ8_9BACT Unreviewed; 2186 AA.
AC A0A0S4LHJ8;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Putative Multi-domain non-ribosomal peptide synthetase {ECO:0000313|EMBL:CUS36981.1};
GN ORFNames=COMA1_30351 {ECO:0000313|EMBL:CUS36981.1};
OS Candidatus Nitrospira nitrosa.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=1742972 {ECO:0000313|EMBL:CUS36981.1, ECO:0000313|Proteomes:UP000199032};
RN [1] {ECO:0000313|EMBL:CUS36981.1, ECO:0000313|Proteomes:UP000199032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COMA1 {ECO:0000313|EMBL:CUS36981.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CZQA01000009; CUS36981.1; -; Genomic_DNA.
DR STRING; 1742972.COMA1_30351; -.
DR Proteomes; UP000199032; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000199032}.
FT DOMAIN 1003..1077
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2077..2151
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1075..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2186 AA; 241773 MW; E7D87E3761A6A33D CRC64;
MKPTHPGTFT GPTAPAASPT NVDVFPASFA QKRLWFLSQL EPDSASYNTA LAVRLRGALN
REATVLSLNE IVRRHEVLRT TFDEVEGELV QVIAEDRPID VPVVDFSLKS PSQREASAAA
AAQAEARRPF DLRSGPVMRV RLLKLRPQEH ILVLTLHHIV CDGWSSQILA QEFGALYEAF
DAGLPSPLPP LPIQYADYAV WQGGWLQGSV IEERLAYWKE KLKGKLPVLD LPSDRPRQVI
QSDRGARFPF SVSRDLVDRL QTLSRTQGAT LFMTLLAAFQ VLLMRYSGLD DFCLGTPVAN
RPKRETETLI GFFANTLVLR ANLSGNPTFT DLLARVQETV LGAQAHQDLP FEQLVDALQP
VRTLSHTPLF QVMFALQTSL ARSLTITSLE VRAMELDAGG AKFDLSLDMT EDETGLDCAF
EYNQDLFDQV TVARMASQLK RLLEGIVDNP QDRLHELPML TEKERRKILT EWNDTAAGTT
EGQVARLFEE QVARSPQAVA VSCGEEALSY RDLNDRADRI ARALSIAGVG CESIVAVLGE
RSINYVALMI ALWKRGGVYL PLDPGHPPSR WTSILETSQA SMVLTTEAWA SRTNDAIARL
PEAGRPGILT VEACLSENPA PSGDGTAWPS SKLAYVIYTS GSTGIPKGAM VTEGGLINHL
RSKVSMLRLG PSDVVAQTAS QGFDISVWQL TAALLCGART LIVPDETARD PEQLLRYADT
QEVTVLETVP ALLRGMLDSA AATGNEAPRL ARLRWVLPTG ETLPPALVRR WFERYRHVPL
INAYGPAECA DDVAMATITV PPDDTYAHSP IGKPIVNLRL YVVDDWLEPV PIGAVGELCV
AGAGVGRGYL YDPAKTAEAF VPDPFSGELG SRLYRTGDRV RHRSDGTVEF IGRRDHQVKI
RGVRIELGEI ELRLQAFPDV REAAAVVRQD HPGQKRLVAY VVPRDGASYD SDILIRSLRE
QLPEPMVPSA IVRLEMLPRS VNGKIDREAL PQPDRVAARE WTAPRTPTES QLAAVWAEVL
GLERVGVHDN FFELGGDSIL SLQVISRAKA QGLPLTPRDL FQHQTVAELA EATGNRIETG
DSQSKPGIRA QRPTDSVRLE TARRLYAEAE DVYPLTPLQQ GLLFHSLYEP QSGIYIEQLS
CLLRGYLDHA AFIDAWRMVI GRSTPLRTAF MWQKLNSPMQ VVLPGEAPPI IELDWRDLPE
SEQRQRLQEF LQEDRLTDFD LTRPPLMRLA LIRIADDARY LIWTHHHIVL DGWCLPIILS
DLFACYACST GGPDPRKPQS QPYRDYVEWI LSQDQTAAEQ YWRKTLAGMT APTPLPTDLA
QNDVQPATGY GIHRLAISAA RTSALQAYAS KERITVNTLV QGAWALLLSR YSGEDDVLFG
TTVSGRSADV PGIETMLGLF INTLPLRVAV PRDAILQTWL RGLLQQNAEL RQYEHTSLAQ
IQSWSQMPRG GRLFNSLLVF DNHPTDQTLD DGGAGLTAHD VSLQGQTNYP LTVNVVPGDS
LCFLLSYQQK QFSPEQVGRI AEHLDMVLSQ LVEPSETRLS TIGVLRADER RLVLEGWNAT
RQKYSMDATV PELIYENVMR TPEATAVRFD EQALSYRELW TRSQALASEL RRHGVGPDVL
VGICTERSLE LIVGLLGIWQ AGGAYVPIDP RYPADRIGYM LADAAPPILL MQPALREQLP
PFAGLYLELY AAASVAETPV LPPTPVRLQH LAYTIYTSGS TGRPKGAGNT HGGLLNRLQW
MQEYFSLTPA DRVLQKTPFG FDVSVWELFW PLMTGAELVL AQPDEHKDGL RLKERIVKQK
ITTLHFVPPM LQAFLETPGV QACAGSLRRV ICSGEALTAT VQQQCWTKLP GVELHNLYGP
TEAAIDVTVW SCDQKAPADP VPIGRPIANT QIYLVDHRDE PVPIGVPGEL YIGGVNVARG
YHKRPALTAE KFVPDPFSAE PGRRLYRTGD LARYRADGAI EYLGRLDHQV KIRGVRIELG
EIESCLLQHP TVHEAVVVDQ DTAAGSKRLV GYVVPRMGHD VTGEMIRQWV AVRLPEAFVP
DLVVTLEALP LTPHGKVDRK ALPLPDTETS RTQSYEEPVT ESEHILAAIW AEVLGQPRVG
RLDNFFELGG DSINTLQVLA RAHQRGVKLT PKQLFEHPTV AAAAAVAVPI EVVAEETSQT
EETEVGTRVD IELSDEDMSN LLEELK
//
