ID A0A0S4LJN1_9BACT Unreviewed; 654 AA.
AC A0A0S4LJN1;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=COMA2_30069 {ECO:0000313|EMBL:CUS37086.1};
OS Candidatus Nitrospira nitrificans.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=1742973 {ECO:0000313|EMBL:CUS37086.1, ECO:0000313|Proteomes:UP000198736};
RN [1] {ECO:0000313|Proteomes:UP000198736}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Luecker S., Luecker S.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CZPZ01000023; CUS37086.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S4LJN1; -.
DR STRING; 1742973.COMA2_30069; -.
DR Proteomes; UP000198736; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CUS37086.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198736};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CUS37086.1}.
FT DOMAIN 13..85
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 111..426
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 654 AA; 73699 MW; 9E0279D8CB50329C CRC64;
MNKAKIVHQD PALRQAAGQD FYNTSKFTLR DLKARASQQQ LKADFGAYLD GFSPNVQDIL
EKFEFRNQIP RLSKSDALGT LINKFLSPDI NLSPNPVKNP DGSVKHPGLD NHAMGTIFEE
LVRRFNEENN EEAGEHWTPR DAVKLMAKLI FLPIADQIKS GTYLLYDGAC GTGGMLTVAE
ETLQQLAAEH NKKVAAHLYG QEINAETYAI AKADFLLKGE GEAADNIVGG PEYSTLANDA
FPSREFDFML SNPPYGKSWK SDLERLGGKE GIKDSRFVIQ HAGEAEYSLI TRSSDGQMLF
LANMLSKMKH KTKLGSRIAE VHNGSSLFTG DAGQGESNIR RWIIENDWLE GIVALPLNMF
YNTGIATYIW VLANRKSAHR KGKVQLIDAT QWFKPLRKNL GKKNCELSED DITRICDTFI
DFKETEQSKI FPNETFGYWK VTIERPLRLR VDLDAQSLSA FRTICEEEEE APLSNLAERV
AGQLGPGPHL NFNEFVKTVE ADAEKHNIKL TGARKKLLKD QLAKRDETAA EVIRKIHKPG
KNKPDPLRGL FETTIDGKLC VTEYEPDTDL RDTEQIPLLE DGGIEAFIRR EVLPHVPDAW
YDAESVKTGY EISFTRYFYK PQPLRLLEEI RADIMALEKE MEGLLGEIIG DTRR
//
