ID A0A0S4LNM2_9BACT Unreviewed; 514 AA.
AC A0A0S4LNM2;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=COMA2_60017 {ECO:0000313|EMBL:CUS38847.1};
OS Candidatus Nitrospira nitrificans.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=1742973 {ECO:0000313|EMBL:CUS38847.1, ECO:0000313|Proteomes:UP000198736};
RN [1] {ECO:0000313|Proteomes:UP000198736}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Luecker S., Luecker S.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CZPZ01000033; CUS38847.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S4LNM2; -.
DR STRING; 1742973.COMA2_60017; -.
DR OrthoDB; 9804645at2; -.
DR Proteomes; UP000198736; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45453; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR PANTHER; PTHR45453:SF1; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CUS38847.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198736};
KW Transferase {ECO:0000313|EMBL:CUS38847.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 278..497
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 514 AA; 57509 MW; 41B94E2F2B419D3A CRC64;
MFNTLYGKLA AVLFGLFCVI GAVAVALTLY STRLYFQEVS QKLNRTLAER MVSEQVLMLE
GRVNEEALKE VFHQLMVINP SIELYLLDPQ GTILTFSAPP GKVKRQRISL EPLERFLSGA
EDFPILGDDP RDITRRKVFS VFPIETLDGS LEGYLYIILG GEEFDSVMQM LEQSYILRLS
LWTVGAILVG TLLAGLLCLK LLTRRLSSLA SVMETFRCGE LVTQPDVSSP ADAEPSATRR
GDDIDQLAMT FSHMTSLIRQ QVHQLKETDQ LRRELVANVS HDLRTPVTSL QGYLETLVLK
EGMFSQQERQ RYLGIAIAQS KRLGELIEEL FELAKLNSQE MKPRIESFSL SELVQDVVQK
FRLTVEAKQM TLQAKLGEDL PFVSADIGLI ERVLENLIEN ALRYTLQGGR ITVILNRMGE
NVMTRVTDTG CGIPPEDLPH VFDRYYQVGK NHRSNDKGAG LGLAITKRIL ELHGSAIEVQ
SVVNQGTTFV FHLAVAQPSV LPVATVTTEY SSHM
//
