ID   A0A0S4LQE0_9BACT        Unreviewed;      1792 AA.
AC   A0A0S4LQE0;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=Putative Multi-domain non-ribosomal peptide synthetase {ECO:0000313|EMBL:CUS39166.1};
GN   ORFNames=COMA2_70002 {ECO:0000313|EMBL:CUS39166.1};
OS   Candidatus Nitrospira nitrificans.
OC   Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC   Nitrospira.
OX   NCBI_TaxID=1742973 {ECO:0000313|EMBL:CUS39166.1, ECO:0000313|Proteomes:UP000198736};
RN   [1] {ECO:0000313|Proteomes:UP000198736}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Luecker S., Luecker S.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CZPZ01000034; CUS39166.1; -; Genomic_DNA.
DR   STRING; 1742973.COMA2_70002; -.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000198736; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd05931; FAAL; 1.
DR   CDD; cd19531; LCL_NRPS-like; 1.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR040097; FAAL/FAAC.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198736}.
FT   DOMAIN          593..668
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1674..1749
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1753..1792
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1792 AA;  197903 MW;  A6E782CF7EA4AB4F CRC64;
     MASEERKGVV TLVDLLRRRA DDLADRPAFI FLIDGETETC ELTYGELDRR ARAIAARLQS
     FGARGDRAVL LYPPGLDYIA AFFGCLYADI VAVPAYPPQR KRTLGRLRAV LANSGATIAL
     ATTKVRAGID RLCGQDSGID EFGSVRWIET DALPRNIESA WQTPSVTGQT LAFLQYTSGS
     TGSPKGVMVS HGNLLHNQRM IHKAFGHNEE TTVLGWLPLY HDMGLIGNVL QPLYLGRPCV
     LMSPVHFMQK PFRWLSAISR YRATTSGAPN FAYDLCVRQI ALEERDQLDL SSWSVAFNGA
     EPIHAGTLDR FSERFAPCGF KRAAFYPCYG LAEATLFVAG GKQGALPVVR TVEKTAMERG
     RFIDSPQTNS SAQRLVGCGR TSADQEVMIV DPDTLSRCLE GRVAEIWVKG LSITQGYWGS
     PEATAAIFLA KTVDTGEGPF LRTGDLGVIQ HGELFVVGRL KDLIIIRGRN HYPHDIEATV
     QESHPSLRPG CGAVFSIPVE DEERLVVVQE VVGNSAIDFD SVAAGVGRAV TEYHEVQVHA
     VVLIKPGTLP KTSSGKVQRH LCRAKFLAHE LEAVHATFHD EPAETGVALA AADVDDEVVA
     TVAEVWAQVL DRPHVEPGAN FFELGGDSLR GIQVLAKLQA IYGVDLPLES LFDAPTAAGL
     ATQIQAGSRS TSSPARTHLE PTIRQDLTPL SFSQQRFWFL DQLAPGSSFN NIPVALRIGG
     ALDLTALRRA LTEIVRRHEI LRARFIIDQG HPAQVIDPPC DLPLPVEDLT SLEGTVQEEH
     VTALASNEAH QSFDLMAGPL IRARLLRLSQ TDYVLLLTIH HIVADGWSMR IFGLELTQLY
     EAFKKGTDSP LVPLSRQYLD AVLHQRRCVD SEEWQRQETY WRRQLASVPH VLELPTDRPR
     PAVQGQKGDR YAWTVPEDVG RRLHDIGCRQ QASLFMTVLA AFDVLMARYS GQSEFCIGTP
     VANRSHLESA SIIGCFVNTV ALRADLSGHP TFLDLLTQVR KTVLEAQANQ DLPFERLVDA
     LQVPRSLSHT PLYQVMLTLE EEQPELCRLD GLDARRMKTS LRTSAFDLTL ELVAMKSGVL
     EAVFEYSTDL FTGETIARMA GHFQELLGQI ALHPDAPVSE LGMLGNDERR RLLQDYNDTA
     ASYPHELCLH QLFEHQTKRT PDAVALVWEG VSHSYRSLNG RANQLARHLR SLGVEMESRV
     ALCLDRSLEM GTALLGALKA GAAYVPMDPS APQERLSVMI QDSGARLLLT QKRFAALFRD
     ATIPVIALDE AWPALASLSD LDCPSYAVPQ SLAYVLYTSG TTDRPKGIEI SHHALVNHST
     AMAKHYGLRP ADRVLQFASI SFDVAAEEYF PTWAAGASVV LRPNEPVPEF SEFGRFIDDH
     GLTVLNVPTP YWADWIESCE QPGTALPVSI RLVIVGSEKA RPDSLVRWER LVGDRVAWCN
     SYGPTEATIT ASYFMPEGGE DWISASTVPI GRPIANVEMH ILDSACRPVP IGVAGELYIG
     GAGLARGYHR QAARTAEQFV PHCFSREPGR RLYRTGDKAR RRADGQVEFL GRYDDQIKVR
     GFRVEPAEIE CRIKQHPAVK DALVLQDSNE QPDGSAGARA QEPRLVGYIV HRGETAATAH
     DLRRFLAARL PGYMIPAEWI FIETMPLTSR GKVDRRALRA LAELVPKRES VSSPLQTDTE
     RAIADIWKKI LGRESVGRQD NFFDLGGHSL LLTKVLTQVR AISARPLAMV DLFQYPTVQA
     LAAYLNGDGP SIGHNEASGE ADQMHKTKER RMAGIRRVQR QRQQRQTTTD RT
//