ID A0A0S6VWY5_9BACT Unreviewed; 630 AA.
AC A0A0S6VWY5;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=MrdA protein {ECO:0000313|EMBL:GAK50479.1};
GN ORFNames=U14_01710 {ECO:0000313|EMBL:GAK50479.1};
OS Candidatus Moduliflexus flocculans.
OC Bacteria; Candidatus Moduliflexota; Candidatus Moduliflexia;
OC Candidatus Moduliflexales; Candidatus Moduliflexaceae.
OX NCBI_TaxID=1499966 {ECO:0000313|EMBL:GAK50479.1};
RN [1] {ECO:0000313|EMBL:GAK50479.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sekiguchi Y., Ohashi A., Parks D.H., Yamauchi T., Tyson G.W.,
RA Hugenholtz P.;
RT "First genomic representation of candidate bacterial phylum KSB3 points to
RT enhanced environmental sensing as a trigger of wastewater bulking.";
RL PeerJ 3:e740-e740(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; DF820456; GAK50479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S6VWY5; -.
DR STRING; 1499966.U14_01710; -.
DR HOGENOM; CLU_009289_1_2_0; -.
DR Proteomes; UP000030700; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030700};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..239
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 271..604
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 630 AA; 69894 MW; 8AEEA7E9F484D333 CRC64;
MHQQFHQRSS IIVKFRLGVY IGVVLLLFAV LVGRLWYLQI IQGEQFLKKS EENRIRLLRI
RAPRGIISDA DGFALVRNRP SFNVYLIRED VPLKKGGKTQ DFETIAAHLD ELLPISKDEI
LDKINKSTRP KFEPTLIFRD ASLKTVAYLE EHKIELPGVM VDVEPLRYSI YDSGVCHVVG
YLGEINEKEL KDTLNNPDAV QGDLVGKSGI EQTFNLYLSG KPGGKQIEVN AHGRELETIS
QKNPMPGNNI MLTLNLHIQL IAEEALGDKI GAIVAVDPRN GHILAMVSHP GFNPNFFAGG
ISSDNWKSLV KNPDKPLQNK AIQSHYAPGS TFKPMIGSAL LQNRIVSSTS ASFCGGQFSA
ANTTKRCWKT GGHGYLNIKQ AIEQSCNVFF YRNGLELGID ELARYAMSFG LGAKSGIELP
NEVPGLIPTR EWKQETIGDK WYPTETMDAA IGQGFVAVTP LQLAMMTSVI ANGGTLYKPQ
IVKKIVRPNG EILKEYEPTV VRKVPIDEKH FKTIREGMWM VVNGTKGTAR GSQLKTFQFA
GKTGTAQVVK LQRGSQEGLP EKFRDHGWFI CFAPAEKPEI AMAIIVEHGM GGAKAAAPVA
KYIFERLFTP QELLVEQPVM EPTELDTLED
//
