ID A0A0S6VX77_9BACT Unreviewed; 1622 AA.
AC A0A0S6VX77;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Serine/threonine protein kinase with WD40 repeats {ECO:0000313|EMBL:GAK50003.1};
GN ORFNames=U14_01228 {ECO:0000313|EMBL:GAK50003.1};
OS Candidatus Moduliflexus flocculans.
OC Bacteria; Candidatus Moduliflexota; Candidatus Moduliflexia;
OC Candidatus Moduliflexales; Candidatus Moduliflexaceae.
OX NCBI_TaxID=1499966 {ECO:0000313|EMBL:GAK50003.1};
RN [1] {ECO:0000313|EMBL:GAK50003.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sekiguchi Y., Ohashi A., Parks D.H., Yamauchi T., Tyson G.W.,
RA Hugenholtz P.;
RT "First genomic representation of candidate bacterial phylum KSB3 points to
RT enhanced environmental sensing as a trigger of wastewater bulking.";
RL PeerJ 3:e740-e740(2015).
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DR EMBL; DF820455; GAK50003.1; -; Genomic_DNA.
DR STRING; 1499966.U14_01228; -.
DR HOGENOM; CLU_005857_0_0_0; -.
DR Proteomes; UP000030700; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR CDD; cd00200; WD40; 3.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44129; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR PANTHER; PTHR44129:SF13; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF07719; TPR_2; 2.
DR Pfam; PF00400; WD40; 15.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00028; TPR; 2.
DR SMART; SM00320; WD40; 18.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 3.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 15.
DR PROSITE; PS50294; WD_REPEATS_REGION; 14.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:GAK50003.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000030700};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:GAK50003.1};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transferase {ECO:0000313|EMBL:GAK50003.1};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 143..425
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 448..481
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 551..584
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 711..752
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 753..793
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 835..876
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 877..918
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1049..1090
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1091..1132
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1133..1174
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1175..1206
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1300..1341
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1342..1383
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1384..1425
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1451..1492
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1493..1534
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1535..1576
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1577..1611
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 172
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1622 AA; 180603 MW; 2D9A79369A52A227 CRC64;
MDEKKSEVPH PSEKKQEQAA KDLTAMFSDE KDEDFDPTLT GRWMYSPQPQ APFFNEHEEE
WDDDEISHQE IFSSLTASIT QETKQSFSVL SLSDELEAFA EKRTQESESV EPFSPSAPSF
RKEVEALQEK LHWKVGAVVD GKYEVKGVVG RGGMGIVYNV RHREWDVELA VKMPLSYSEA
SEIFKARFIR EAQIWVNLGM HPNIVQCWYV RELGGIPCVF MDYISGGSLK DWIKAKKIQP
GEWGKILDFI IQACDGLGYA YQNGVAAHRD VKPGNLLLSS DGRLHVTDFG IVRHQKEQDI
ETQSVTLPVG VAGLSMTITG SDLGTPEYSA PEQWGKAKEA DPRSDIYALG GILFELCCGR
RPFDDGKQRE PAQVMIGRHL FMPPPDPRAF RTDVPADLAN LILTCLQKDP EKRPASIAKL
RQQCVEIYAS AVGKPYERPE PQTTELRSNA LNNRAVSLLD LGQKFEALAA FNEALKLDPH
HPESVYNKAL VEWRDRQIND EEVIRRLKEA KQASPRAGLY LANIYAEQAA ADAAERELIE
TIEHGAVIPY SAIWRALGDA QMAQEKFAEA SDSYEKALEL LPDDQALQQR RSLVNQQNRS
LDGQILFPWP HCLHTFVGEK SDVKSATLTP DGRLALLRYQ HEFKLWDLTS GETLWTFIWN
AAHEQWNCKG QANTTTSVGL TPDGKFLLSS HSKSSHLVLW ELDTGRCLRT FTGHTDGINA
IIMLPGGNHI ISGSADMTLR LWDIRTGESL QEFRGHTNPV KSAAVTPDGQ YLFSCGGESV
RVWEVLTGKY LKRLAGKDRI SVLAVSPDGQ KIFAGCQDGL IRIYSWPLGR LLHSFSGHGS
VVTMLAVSPD GRFVVSSSSD KTLRVWNVST GKIAHLLKGH TAAVTSCALA KNGRLLISSS
RDRTVRLWNM ATGECIRVLQ AFSHWMECVI PTPGENAIII GNGEELRLLR LQDGQYVRSF
VANAKESLSL TTHFAKLQVV EKTSKLLFQL TGDDFSFCWH EGGSAVMIPV SINGRFAIAL
SEKEKLCFSD LQTQALLEMF KGGSGLQSFR KHRNWMTVIV MTHDERLLIS NWFDASVRVW
DVQSTQEVRV LEGHQEIVTA LAITSAGTHL VSGSADKTVR LWNLRTGECL RVFTGHDGQI
STVAITPNAR YILSGSLDKT LRVWDSATGI CVRILSGHAE SIAAAAMTDD GHIAFSAGKD
KTFRIWAVDA DAPRYLATLQ VCRQQEHAEL LLFKERYGKY IARADTAMNQ GKIATAYTFL
ALARAVPGYE RDPAALALNL KLGMQLQRKT LREGRLIRNI EGHTDFITSI SVTPDGRFAV
SGGRDRTVRV WTLANGTSLR ELKGHRGSVS CVAVSPDRYF ALSGSWDTTL RLWALATGEC
LKVFKDHEDY VRAVAITPDG RFAISGSTDT TLRLWYLSPG RHVQGFEGMI VPLEDAYREA
ELTTAKCLRV FRGHTSDVVA VAVSADGRYA LSGSWDTSLR FWSLTNGKCL ETLRGHTNYV
TSVALSSDGR LALSGSRDGT IRFWSVARKK CVRVLHGHDG YVTSVAMTPD RRFAISGGWD
HTIRVWQLST GECLRVFERH TDAVEAISLT PDGHYLVSGG RDRIARYWEF DWRLAPGKHA
EE
//
