ID A0A0S6W4S9_9BACT Unreviewed; 435 AA.
AC A0A0S6W4S9;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:GAK53242.1};
GN ORFNames=U14_04507 {ECO:0000313|EMBL:GAK53242.1};
OS Candidatus Moduliflexus flocculans.
OC Bacteria; Candidatus Moduliflexota; Candidatus Moduliflexia;
OC Candidatus Moduliflexales; Candidatus Moduliflexaceae.
OX NCBI_TaxID=1499966 {ECO:0000313|EMBL:GAK53242.1};
RN [1] {ECO:0000313|EMBL:GAK53242.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sekiguchi Y., Ohashi A., Parks D.H., Yamauchi T., Tyson G.W.,
RA Hugenholtz P.;
RT "First genomic representation of candidate bacterial phylum KSB3 points to
RT enhanced environmental sensing as a trigger of wastewater bulking.";
RL PeerJ 3:e740-e740(2015).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; DF820459; GAK53242.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S6W4S9; -.
DR STRING; 1499966.U14_04507; -.
DR HOGENOM; CLU_021572_5_1_0; -.
DR Proteomes; UP000030700; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF12; BLL1977 PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000030700}.
FT DOMAIN 1..126
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 149..375
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 435 AA; 49831 MW; C8C97C3560143FFF CRC64;
MKITVIRPNM NAQKAADALQ PLVFALLKAL TPLTVEMAFY DDRIEEIPFD VPTDLVAMTV
ETFTAKRAYW IAAQYRERGV PVVMGGFHPT LMPDEARQHA DSVILGDAEA VWPQLVTDAT
RRRLQPIYQA PPLSSPLNAM YDRRIFQGKA YPPLELVQWG RGCAHNCEFC AIRAFYGKHQ
CQRPIKRVIA EIDELDAEHM IFFTDDNLLA DKARFSELLL ALIPLKRRWA AQISIEAAQN
ARMLKLLEQS GCQVMLTGFE SLNHANLRQM NKVWNTTAQD YESAIKRIYD HGIMIYGTFV
FGYDGDTPDV FDRAVEFAIR QRLFLANFNP LTPFPGTPLY RRLQREGRLL RERWWLDTAY
QYGDAMFQPA NMTPEELTQG CFEARKAFNS SVSMLRRAAN IAVNLRSWRR FALYTAANYI
NRKAIFQKQG KALGA
//
