ID A0A0S6W5B1_9BACT Unreviewed; 713 AA.
AC A0A0S6W5B1;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=U14_04894 {ECO:0000313|EMBL:GAK53628.1};
OS Candidatus Moduliflexus flocculans.
OC Bacteria; Candidatus Moduliflexota; Candidatus Moduliflexia;
OC Candidatus Moduliflexales; Candidatus Moduliflexaceae.
OX NCBI_TaxID=1499966 {ECO:0000313|EMBL:GAK53628.1};
RN [1] {ECO:0000313|EMBL:GAK53628.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sekiguchi Y., Ohashi A., Parks D.H., Yamauchi T., Tyson G.W.,
RA Hugenholtz P.;
RT "First genomic representation of candidate bacterial phylum KSB3 points to
RT enhanced environmental sensing as a trigger of wastewater bulking.";
RL PeerJ 3:e740-e740(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; DF820459; GAK53628.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S6W5B1; -.
DR STRING; 1499966.U14_04894; -.
DR HOGENOM; CLU_000445_114_15_0; -.
DR Proteomes; UP000030700; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF13188; PAS_8; 1.
DR Pfam; PF00072; Response_reg; 2.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 1.
DR SMART; SM00448; REC; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 2.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:GAK53628.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000030700};
KW Transferase {ECO:0000313|EMBL:GAK53628.1}.
FT DOMAIN 8..125
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 144..187
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 200..250
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 268..483
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 507..623
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 57
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT MOD_RES 556
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 713 AA; 80146 MW; 9C110B9E1F49F4CF CRC64;
MNMDAPQKVL IVDDEPHLRA GYLRIATQAG YEVASASGVA DGWQRALEFR PDVALLDVAL
GDGSGLDLCR KIKTNPEMSG TLVIMLSGTQ ITSEDQANGL DAGADGYLIK PIQPRELVAR
IKALLRIKEV EIHLQRTLDE LRQSEARFQK VITYHADAIL VVDRQSRIRF ANPAAERLFS
RHKDDLIKQE FGLPIGDADQ FAELEIHQPT GSKIMVEMRA VEIEWDGEAA YLASLRDISE
RKKMEFALQR AKEAAEAANN AKTQFLAHMS HEIRTPLNGI LGYAQLLKRG GDLTDYQQHG
LDVIQQSGEH LLTVINDILD LSRIEAGKLE LSPTNFHLSR SLLTLVEMIK IRAEQKGLSF
IYENESGRAS LVYGDEKALR QVLLNLLGNA IKFTSDGHVA LRVRMAEDGR RIRFDVEDTG
VGIPPEKIDF VFAPFERLHH GQEGTGLGLA ISRRLVEIMG DSLRVQSQIN LGTRFWFEID
LPAIDERSNA PLRHVRRIIG CRGKTPVIGI VDDYADHRRL LKEMLLLCGV AVVEWANGRE
TCEQIERQMP DLVFMDIVMA DMDGLETTRQ LRQRPSLSSL PIIALSASAF EETRQQSLMA
GCQEFLSKPV IEEMLWETLQ QYLPTAWVFE DEPPDVEAVE LPSQAVSSDI PSREQLGRLY
EFTQIGDILG AREEIRLLKL RHPECADFLK QLEAMAARFN LVGIRSHIEQ YAK
//
