ID A0A0S6WZG3_9SPHN Unreviewed; 346 AA.
AC A0A0S6WZG3;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
DE Flags: Fragment;
GN ORFNames=MBENS4_1472 {ECO:0000313|EMBL:GAM04474.1};
OS Novosphingobium sp. MBES04.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1206458 {ECO:0000313|EMBL:GAM04474.1};
RN [1] {ECO:0000313|EMBL:GAM04474.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MBES04 {ECO:0000313|EMBL:GAM04474.1};
RA Ohta Y., Nishi S., Kobayashi K., Tsubouchi T., Iida K., Tanizaki A.,
RA Kurosawa K., Adachi A., Nishihara M., Sato R., Hasegawa R., Hatada Y.;
RT "Draft Genome Sequence of Novosphingobium sp. Strain MBES04, Isolated from
RT Sunken Wood from Suruga Bay, Japan.";
RL Genome Announc. 3:e01373-14(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; DF850488; GAM04474.1; -; Genomic_DNA.
DR RefSeq; WP_039389729.1; NZ_DF850488.1.
DR AlphaFoldDB; A0A0S6WZG3; -.
DR STRING; 1206458.MBENS4_1472; -.
DR HOGENOM; CLU_018284_0_0_5; -.
DR OrthoDB; 9806213at2; -.
DR Proteomes; UP000053513; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..142
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 151..344
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT NON_TER 346
FT /evidence="ECO:0000313|EMBL:GAM04474.1"
SQ SEQUENCE 346 AA; 38626 MW; 3E47814D0A16629D CRC64;
MLTGAIRSQI DKLRDSLWSG GVSNPLTGVE QITYLLFAKR IDEIQTREEA KANQLKRPLA
RRVFPEGKDD LGTPGFPDGC PYELMRWSRF KNEPPERMYE IVSDHVMPFL RTLGGAESVM
AHHMKGARLA FTKPALLDKL VQGLDEIPMD DRDTKGDVYE YLLSMISSAG ENGQFRTPRH
IIDLIVRLMN PGPEDTICDP AAGTAGFLMM AAEHVRREHP GLFYDAESRK HFETEAFTGY
DFDETMLRIG AMNMTLHGIE EPRIFYRDSL AEGGGDDVGH YSMILANPPF AGSLDNESCS
KDLLKVVKTK KTELLFLALF LRMLQTGGRA AVIVPDGVLF GSSKAH
//
