ID A0A0S7BNH2_9CHLR Unreviewed; 737 AA.
AC A0A0S7BNH2;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=ATC1_131721 {ECO:0000313|EMBL:GAP41725.1};
OS Flexilinea flocculi.
OC Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC Flexilinea.
OX NCBI_TaxID=1678840 {ECO:0000313|EMBL:GAP41725.1};
RN [1] {ECO:0000313|EMBL:GAP41725.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TC1 {ECO:0000313|EMBL:GAP41725.1};
RA Matsuura N., Tourlousse D.M., Sun L., Toyonaga M., Kuroda K., Ohashi A.,
RA Cruz R., Yamaguchi T., Sekiguchi Y.;
RT "Draft Genome Sequence of Anaerolineae Strain TC1, a Novel Isolate from a
RT Methanogenic Wastewater Treatment System.";
RL Genome Announc. 3:e01104-15(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; DF968181; GAP41725.1; -; Genomic_DNA.
DR RefSeq; WP_062283518.1; NZ_DF968181.1.
DR AlphaFoldDB; A0A0S7BNH2; -.
DR STRING; 1678840.ATC1_131721; -.
DR OrthoDB; 139066at2; -.
DR Proteomes; UP000053370; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 3.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000053370};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 326..391
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 404..495
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 557..680
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 737 AA; 84373 MW; E00BEF106A3792C7 CRC64;
MKTFLKGWIL DIYEDETDGV RIWFITEENQ RICLKQYLPV RFFAAGPRER LHQYCLAIQG
TPGLLHLSRE NKRDVFKPEP VCVLEIEMDN PVRQRLCFQR LKKDFPDLIY YNADLAVHIH
HAARYHTFPL AFCSVTYDSE NQEILNLEVL NSRWDVAPLH PVLRILEMEP SCDPNKKNPE
SLRLSYNHHT QQIRMSDPAN VLNHINQLIE KIDPDLIQTK WGDDWLFPEL LEMESTAGIP
LKMNRDEERK LFWKKEITYY SYGQIVFRGR EAHLFGRCHI DTKNAVMWSD YHLDGALESA
RVTTLPIEQA ARVSPGSGIS AMQMITALEQ DVLVPEQKQQ IEASKSALDL IQFDRGGLIY
QPRTGLHCNV AEIDFTSMYP AVIINGNISP EVPLPDGLKP ASSVLGIVPL TLKPLYEKRV
LIKEKLLHFP DKSAPLAKSY TARASALKWL LVVCFGFLGY KNARFGRIEA HEAVTRGGRE
ALLIAKETSE EMDCEVLHMF VDALWIQKSG CKKVSDFQPV LDEISRRTGM IISMDGIYRW
IAFLPSRAND DQPVPNRYFG VFEDGSLKIR GIEARRRDVP VWIIETQLEM LNCLAKAADA
RKLPDYLPKA FRIFHNALED INADRIPPEK LIVTNRISRK LCEYKAPTAA VRAARQLLEA
TGKNTAPGQK IRYLYTVGTP DVFAWEIPEP IQREQIDKSK YRELLARAAG TILYPFGINA
KQISDYAHGG LQLNFFD
//
