ID A0A0S7BXV4_9BACT Unreviewed; 443 AA.
AC A0A0S7BXV4;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase {ECO:0000313|EMBL:GAP43435.1};
GN ORFNames=TBC1_111588 {ECO:0000313|EMBL:GAP43435.1};
OS Lentimicrobium saccharophilum.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Lentimicrobiaceae;
OC Lentimicrobium.
OX NCBI_TaxID=1678841 {ECO:0000313|EMBL:GAP43435.1};
RN [1] {ECO:0000313|EMBL:GAP43435.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TBC1 {ECO:0000313|EMBL:GAP43435.1};
RA Tourlousse D.M., Matsuura N., Sun L., Toyonaga M., Kuroda K., Ohashi A.,
RA Cruz R., Yamaguchi T., Sekiguchi Y.;
RT "Draft Genome Sequence of Bacteroidales Strain TBC1, a Novel Isolate from a
RT Methanogenic Wastewater Treatment System.";
RL Genome Announc. 3:e01168-15(2015).
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
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DR EMBL; DF968182; GAP43435.1; -; Genomic_DNA.
DR RefSeq; WP_062040500.1; NZ_DF968182.1.
DR AlphaFoldDB; A0A0S7BXV4; -.
DR STRING; 1678841.TBC1_111588; -.
DR PATRIC; fig|1678841.3.peg.1773; -.
DR OrthoDB; 9764892at2; -.
DR Proteomes; UP000053091; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053091}.
SQ SEQUENCE 443 AA; 49292 MW; 03B8E8B42847C881 CRC64;
MIEKKFISGF SKLTKDLKLS FIAAQMPNGE HIISELKSFW HQDASVQKMF DEFSENTLTN
YFFPYGVAPN VMINGNIMMV PMVIEESSVI AAAANSAKYW AEKGGFHSEI LSTVKNGQVH
FIWKGEFGRL KELFPQLKDQ LLQRTFPITA NMQKRGGGVL DMELIDMTSK LQDYYQLSVK
FDTRDSMGAN FINSCLEEYA SGLRAFVNDS GLFEGEPLQV IMSILSNYTP ECTVRTWVEC
DVKDFADIDD SLTAEDFVWK FEKAVQIARV DVHRAATHNK GIFNGVDAVT LATGNDFRAI
EACGHAWAAR DGQYRSLTEI KVEGGRFHYS LTLPIAIGTV GGLTSLHPMA RFSLHLLGNP
SAPELMQIAS VIGLANNFGA IKSLTTKGIQ IGHMKMHLLN ILNMFNAGES EKLLAVEYFK
HHKVSHNAVA GFLSSIRNGH VKN
//
