ID A0A0S7DLY6_9EURO Unreviewed; 3892 AA.
AC A0A0S7DLY6;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Nonribosomal peptide synthase {ECO:0000313|EMBL:GIM37708.1};
GN ORFNames=ALT_000084 {ECO:0000313|EMBL:GIM37708.1}, CNMCM8060_004705
GN {ECO:0000313|EMBL:KAF4178122.1};
OS Aspergillus lentulus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=293939 {ECO:0000313|EMBL:GIM37708.1};
RN [1] {ECO:0000313|EMBL:GIM37708.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IFM 54703 {ECO:0000313|EMBL:GIM37708.1};
RA Kusuya Y., Sakai K., Kamei K., Takahashi H., Yaguchi T.;
RT "Draft Genome sequence of the pathogenic filamentous fungus Aspergillus
RT lentulus IFM 54703T.";
RL Genome Announc. 4:e01568-15(2016).
RN [2] {ECO:0000313|EMBL:KAF4178122.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNM-CM8060 {ECO:0000313|EMBL:KAF4178122.1};
RA dos Santos R.A.C., Steenwyk J.L., Rivero-Menendez O., Mead M.E.,
RA Silva L.P., Bastos R.W., Alastruey-Izquierdo A., Goldman G.H., Rokas A.;
RT "Genomic and phenotypic heterogeneity of clinical isolates of the human
RT pathogens Aspergillus fumigatus, Aspergillus lentulus and Aspergillus
RT fumigatiaffinis.";
RL bioRxiv 0:0-0(2020).
RN [3] {ECO:0000313|EMBL:KAF4178122.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNM-CM8060 {ECO:0000313|EMBL:KAF4178122.1};
RA Santos R.A.C., Steenwyk J.L., Rivero-Menendez O., Mead M.E., Silva L.P.,
RA Bastos R.W., Alastruey-Izquierdo A., Goldman G.H., Rokas A.;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GIM37708.1}.
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DR EMBL; BCLY01000008; GIM37708.1; -; Genomic_DNA.
DR EMBL; JAAAPS010000027; KAF4178122.1; -; Genomic_DNA.
DR STRING; 293939.A0A0S7DLY6; -.
DR VEuPathDB; FungiDB:TMP_alenIFM54703_3428; -.
DR Proteomes; UP000713487; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 3.
DR CDD; cd19542; CT_NRPS-like; 2.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 775..849
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1841..1919
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3375..3448
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3892 AA; 430057 MW; 7B91CB2D694AB495 CRC64;
MTFQVHTPSH SLSRVAEFAC LFPRFGEDAN CKETYQSVEL DATASQLVQS CSSLYQSKPA
LVLSTVWAAT LQSFTEGERV KFALFQKEPV HGVCCAQGGK EYVRGEAYAA LIHPETPASE
LMKQDNWEIL PHVPGDRFLN TGLCIAGEDE AEFATILKGL DICIVCRPES LRMTLLFSSK
SLSRTFARAI ASAIPQGMQH ILKYPTTSIG EMNLFSQTQE ELVKSWQCSE PLQTQSCFLF
DFLSRQAVKQ SGALAIDAWD GRWTYQELDE TSTILASHLQ ACGVRSGVLV TVCFEKTCWA
VVALLAVNKA GGGFVPCDPT YPVERREKIL QQARSPLILT SAKCADLFAG RENPAVMVIS
SATFSELQTA SYRRPVDGEA PAYVLFTSGS TGEPKGCEIS HEAFASISNH VKALHLGPAS
RALQFASFSF GMAIIEIFCA LVAGGTVCML SDEQRLNSLA GTMTEMKIDW ALMTPTVLGS
LQPHDLPYLK CLLVAGEALN ESQIQIWGST LELFQAYGLT EWTGIFAVSD KITSIRQRRT
IGVPANGQAW LVDPRDPHKL VPVGAAGELV IRGPGLASGY YRDSERTRAR FFSSKWLNHW
SSHGGSRVYR TGDIMRYTAD GSLSYVRRAD NQVKIRGMRV ELNEVEYNLM QLIPEARQAV
AMLWKPQERD GQPVLLALIQ MPPSSESKPA VLDSTDGQLL FLQPTAERSR AMDTALEGLH
SRLPDYMVPQ YLLALAAFPT TVTGKVDRRK LASLTNGLTT DDLKYLAGRQ AEHQAPTTDS
ERQVYDLACT VLGVKSVSMG DNFFDLGGDS VAAMKMAGLA RRRKIELTVA DVFDRPVLKD
LAVAIRQPNG SMTSQRVAFG LLNAADRPRI IHEATNAMDT GHIVDIYPCT PLQEGIWALS
ARNPALYKAR VISHLQPDVD LDRFRKAWER VFELNDILRT RLFPSSSGLF QAVLQESFEW
DTAEELQTYL DRAGQEQMGV GRRLVRACLL TEKDQATFVL TIHHALCDRW SLRLLLEQIE
KQLSPLPPSA HHAFSPFIEH LVNIAPQFEK FWVDQFQGFE ASPFPVLPSP DYTPTAHHIS
RSNVGLPRRV LRDRTLASHL RLAWALVISH NICSDDVVFG STVTGRGSNL SGIETLSGPT
IATVPFRAVL NPAGTVADAL AAIQAQSISM MPFEQVGLQK IQRYSPEAES ACMFQSTLTV
QHALPNSFTL FKDCQEGAAT PGGFASYALC LECYPDTEET QLEIQVAYDS NVIPATRMGR
LIDHFRFALY EIMEAPDKTI REIQHISPSD LIQLGRWNDN IPPQLRQTIH GVVQGQAEKT
PHSPAVSSWD GDLTYQELER YSTQLRDELL LRGAKPGMLI PLLFEKSRWA IVAMLAVLKA
GAGIVALDPS YPVDRMRAIC GQVQSPLGIC SERYAATMEK IGPKPIIASE SSSTWDRAVE
ELNLLAVDAD ATMYLIFTSG STGVPKGVIV SHGSFASSTL AYRAEINLDA NSRLLQFCSF
AFDVCFAEIF GALMAGACLC IPSDADRMND IHHAMRKLHV THAFFTPSYA RLVKPDQVPS
LRVVMLAGEP VKASDVEHWA PHVRLVNGYG PSECAPISAT QHIDGSADIQ PQDIGYPQGC
VAWVCDPRDH DILLPVGAVG ELVIEGPNVG SGYFQNASET MKAFVDAPLW LKAFRGRTSK
RVYKTKDLVH YTEDGRLRYV GRIGQQAKLR GQRLEPSHVE HHLLQAFEGA VEVAAIVATP
KDAGGRATLV AFVLSENATA RSGEDICLPA SEEFCLLTAS ARSKLQQSLP EFMVPSLMIS
VSSMPRTPSG KLDRQLLTLE ITSRTWDQLM QFETSVDSSH VVVSDTEREL QAIWSRVLNL
PVSAIGTNKS FFQLGGDSIT AMLVVAQARG GPLSLNLTVE DIFRLRTISQ IATGATANSS
DLPLLANHDL LDTPFDLSPI QQLFFETNGL QKQNRFNHNL FLRLRQPVTF DQLRLAIHEI
AEEHPLLRAR FLQNANGEWQ QLIPSEIEGS YGCKHHRLTS ADMVKKVLAG SRQALDISAG
PIFSADLIEI NGSQSIFLLA HHLVIDMVSW TVLLSDLETL LQGRPIPKGQ STSFQTWCSL
LAAHGHKTFS VPQELPQCDA LQDFWGTSDG LNTIGGAREM VIQVDTATTE ALLGEANKAL
GTQPVELLHA ALLFAFTTTF SDRPAPVIFT EAHGREPWDS GIDLTRTVGW FTTIAPVPVK
VDAAHDIFTV VGRVKDTRRR LHKNGLEAFT ANYFNTRKQR TSPAGKMEIV FNYGGRYQQQ
LGQAGSFFEV ESLQTMSIFD AADDARRWSM VDINAFVEDG KLSFTFTFPQ GYNASQAVQS
WTASLRNCLN LVASEFRNHP RSYTLADFPM LDLDYPQLDH LLMALHRANI QPQDIEEIYP
CSPMQRGILL SQAKDPSCYH VIMTWEIVSG EKGTASAERA KSAIEQVMAR HASLRTCFIE
TTSEVAAFDQ VVLREPHHQI PIFHSGENDT RALLQSDQFQ PSPHSPLRFS IHVSCDQKVY
IRLDISHALT DAKSTELLKR DICLAYENQL NSQRGPLFSN YISFIQTRDH VDDAEFWDTY
LDGIQPCQFP ALTEQVNTES GVAKDYVFDA AGVYGIEAYC RDRNVTAPNV FGLAWALVLG
SYTGADDVCF GSLNSGRELP FDGAPEIVGP LINLLTMRVN LKDATLQQLV RQVHADYAAG
LAHQTYPVAD IFHRKGLGGR SLFNTGISVE RVSSPQDAQS ATELRLVQRV DPTEYDIVLN
VEIEKTRTIV HLRYWSSCLS DSQAPLIAAC FDQALKMIIN DDHTPACRVN LFCQPHQDLI
WRWNKVLPSS RDCLVHDLVQ QHATKNPDAP AVCSSESTLT YAEVDVHSTA LAHYLSQQGI
GTETFVPLCF EKCIWTVVAI LAVLKTGAAF VLLDPGHPDQ RLETICQDVG SPLLLSSPTQ
AARCARLSST VVVVGGTQDL WRGLCPAGSS PLLSAATQPG PNNAAYAVYT SGSTGKPKGI
IIEHRSLCSM IHAQAPILDM TPSARMLQFS SYAFDVSIFE MLMPLMTGAC VCILSEVERR
DRFVETVVSL QVSHALLTPS FSRLISPDAL PDLQVLVCGG EAMTQHDMKR WLGHVRLINH
YGPAECSVCS VVQPNINTTS RVGEIGWGVG CATWVVDTDD HERLVPVGAV GELVIEGPIV
GRKYLNNPTA TQTAFIEPPQ WLHNMRSSLG SNNRLYKTGD LVRYGSDGRL YILGRKDTQI
KIRGQRLELQ ELEHHVHRCF GSAGNVVVEL VRNGPDGNPR LFAFIGSTKE MSSQFDGFSV
AGKEFRDCAA AASMKLFESL PSYMVPTYFI PSATLPLNSS GKVDRKRLQS LAAAFTPDQL
KDYCPSAGGQ RKPSSPEEKL LHAIWVDVLG VEPETIGVDD HFFQAGGDSV NAMRVAASAR
KQGLNIVVAD IFAHPRLEAL AKAGTRGKVE QFAPAPFSLC PVSDPELFTM LLRVRRTIPS
DSHVVDILPA SAAQSFFLTR PTLHHFTFDI EGSLDIRRLR DACDKVFNMF TVLRTVFVPH
EKQILQVIID KVDTPFHHFV VDGAIPDVRE RLLTADRQHI PLMGQLAFAF VLISHSDGSR
HSLSFRISHA QWDGLSIAEL FGSVQEAYHE RPLTPSTPLS TYIYYRALRD KSHSLQFWRE
YLQGSTITRI TDVPSELTDL SHGDTIWENT NLQPAPEPPL GITMASVVKS AWSLVLARER
GARDIVFGQT VNGRSSPLPD IDRILGCCLN FIPARIQLQE SWTGRDLLQH AQSQYQKSVQ
HDDIELQEII DHCTDWQSGT DFNSIVQHQN IPLNHTMPLG DFQSTFSPNG YFRPGPELFI
FTEPFGDILS VQLCVNPNMM GLPRAQSLHQ RLVQLIVDLC RSPDEPISCF LG
//
