ID   A0A0S7E2M4_9EURO        Unreviewed;       689 AA.
AC   A0A0S7E2M4;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KAF4173268.1};
GN   ORFNames=CNMCM8060_000308 {ECO:0000313|EMBL:KAF4173268.1};
OS   Aspergillus lentulus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=293939 {ECO:0000313|EMBL:KAF4173268.1, ECO:0000313|Proteomes:UP000713487};
RN   [1] {ECO:0000313|EMBL:KAF4173268.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CNM-CM8060 {ECO:0000313|EMBL:KAF4173268.1};
RA   dos Santos R.A.C., Steenwyk J.L., Rivero-Menendez O., Mead M.E.,
RA   Silva L.P., Bastos R.W., Alastruey-Izquierdo A., Goldman G.H., Rokas A.;
RT   "Genomic and phenotypic heterogeneity of clinical isolates of the human
RT   pathogens Aspergillus fumigatus, Aspergillus lentulus and Aspergillus
RT   fumigatiaffinis.";
RL   bioRxiv 0:0-0(2020).
RN   [2] {ECO:0000313|EMBL:KAF4173268.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CNM-CM8060 {ECO:0000313|EMBL:KAF4173268.1};
RA   Santos R.A.C., Steenwyk J.L., Rivero-Menendez O., Mead M.E., Silva L.P.,
RA   Bastos R.W., Alastruey-Izquierdo A., Goldman G.H., Rokas A.;
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00006743}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAF4173268.1}.
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DR   EMBL; JAAAPS010000109; KAF4173268.1; -; Genomic_DNA.
DR   STRING; 293939.A0A0S7E2M4; -.
DR   VEuPathDB; FungiDB:TMP_alenIFM54703_6410; -.
DR   Proteomes; UP000713487; Unassembled WGS sequence.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR004621; Fadh2_euk.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   NCBIfam; TIGR00677; fadh2_euk; 1.
DR   PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   REGION          325..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   689 AA;  77062 MW;  A1AE37285128E82A CRC64;
     MEKITDKIAA LPPNENYFSL EFFPPKTQMG FSNLTARLER MSQALRPLFV TVTWGAGGST
     AARSLELAEI CQRQLQLTTC LHLTCTNMSR ALIDEALEEA KVLGIRNILA LRGDPPRSEE
     YNMHGEDDSN KDFTFAVDLV RYIRKKYGDY FCLGVAAYPE GHPVDSYQDV QDPVRDLPYL
     VEKTLAGADF IMTQLTYDIE AYTKFEEMLR NHESGAFKTI PIIPGLMPIH SYKILTRTTK
     LSHVKIPPQI MASLEAVKHD DDAVKRIGVD VLSDLVEAIK KIPCPGFRGF HFYTLNLEKT
     VSFIIERCGL IPDYPEDTNA VVDDDYTTAP TGAQNRSLSR RRASSVNSHP HNRVIVDRLQ
     VPSDGSSRAS THEAPAASAG MPAMPPDRNT TLQISEGQGA LGREATWDDF PNGRWGDARS
     PAFGEIDGYG PSLHVSGAVA RRIWGYPVSR EDISALFRRH VSGDLYIVPW SEGGAEENSS
     GLNAETEVIR PELLKLIDSK GWWTLASQPA VNGVRSDDPT FGWGPPGEGF VFQKPFVEFF
     CPSKDFQTVL KPLFAKHGHE KLAWFATNVK GEFESSLPAD PAHADTIEMN PNNVNAVTWG
     VFRGKEIVTP TIIEEVSFRA WGEEAFRIWD EWRRVYPRGT PTERLLEEVK NDVWLVCVVG
     QDFGAGTENG SEEEQQETKW MWNVLINSQ
//