ID A0A0S7E4J9_9EURO Unreviewed; 1016 AA.
AC A0A0S7E4J9;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA mismatch repair protein MSH3 {ECO:0000256|ARBA:ARBA00019000};
DE AltName: Full=DNA mismatch repair protein msh3 {ECO:0000256|ARBA:ARBA00022151};
GN ORFNames=ALT_009255 {ECO:0000313|EMBL:GIM44036.1};
OS Aspergillus lentulus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=293939 {ECO:0000313|EMBL:GIM44036.1};
RN [1] {ECO:0000313|EMBL:GIM44036.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IFM 54703 {ECO:0000313|EMBL:GIM44036.1};
RA Kusuya Y., Sakai K., Kamei K., Takahashi H., Yaguchi T.;
RT "Draft Genome sequence of the pathogenic filamentous fungus Aspergillus
RT lentulus IFM 54703T.";
RL Genome Announc. 4:e01568-15(2016).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA
CC mismatches thereby initiating DNA repair. MSH3 provides substrate-
CC binding and substrate specificity to the complex. When bound, the MutS
CC beta heterodimer bends the DNA helix and shields approximately 20 base
CC pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to
CC 13 nucleotides in size, but can also repair base-base and single
CC insertion-deletion mismatches that occur during replication. After
CC mismatch binding, forms a ternary complex with the MutL alpha
CC heterodimer, which is thought to be responsible for directing the
CC downstream MMR events, including strand discrimination, excision, and
CC resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch
CC repair functions. {ECO:0000256|ARBA:ARBA00025373}.
CC -!- SUBUNIT: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a
CC ternary complex with MutL alpha (MLH1-PMS1).
CC {ECO:0000256|ARBA:ARBA00025902}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GIM44036.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BCLY01000017; GIM44036.1; -; Genomic_DNA.
DR STRING; 293939.A0A0S7E4J9; -.
DR VEuPathDB; FungiDB:TMP_alenIFM54703_9532; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
SQ SEQUENCE 1016 AA; 113015 MW; CFC74644F98E47B4 CRC64;
MRINGCRFAR LVPSQFHHVH KFDTSAAHRC LVHRTICHHA HRPHARVELP TPHLELRRGA
RTRTTVKVKD LPQGTLKLEP YDDGATDATD DAPRYPTVVQ GHRNNMQKFR NCVILTRVGG
FYELYFEQAE ELAPLLNLKL AVKKTSAGPV PMAGFPFFQL DRFLKVLVQD LNKYVAISEE
FANATEDKAR GGLLFDRRVA RIITPGTLID EKFMDPSENN FLMAVYIDVA ALKAQLEQQE
GDLSAQQHVL SSASQRVGLS WLDLSTGDYF TQSTTTQMLP SAIARIAARE ILVDQKLQDL
IGQELQLLVG HDHRLMTFFA YPSKILPIAQ WSSVLEAPVA DQDSDAFTPE EVAAGYSLLE
YIRVQLQGLN LKLQPPRRRH LNESMNIDRN SLRGLEILET ARDGFGKGSL LHAVRRTSTK
SGARLLRDRL TSPSTSLQVI NERLDLVSVF LENSDLRDSV IQLLKRSYDA QRLVQKFTLG
RGDADDLICL ARAIQASREI KTVLSSQGNG RLDRLPHIQS IDSKRSLSAM TGRLCLDGPT
MLADRISAAI DEEGLLQKQR LEDDTATEAA ILAQEVAMSE GQPGEVETLP KKVRAKNSDQ
SKASTEETTA PDTWIMRRNA SAALLELHES LDRLQDEKTR LTQRLREAVG SSALSLRWTS
GLGHICHVKG AKISQQSLEA LGVTRNVSST KSTRSFYLPS WTALGDRMDQ VKVQIRQEEQ
AIFETLRREV ILNLVKIRRN AAVMDELDVA CSFATLAEEQ RLVRPILTSG LTHKIVGGRH
PTVKLGLEEQ GRQFVSNDCF LGDSERIWLI TGPNMAGKST FLRQNALITI LAQVGSFVPA
EYAEIGIVDQ IFSRIGAADD LFRDQSTFMV EMLETATILK QATARSFVIM DEVGRGTTPE
DGTAVSFACL HHLHYRNKCR TLFATHFHAL ADMTDDFEAL GRYCTDVKET ASGSFSFVHR
LRKGVNRNSH ALKVAQLAGL PKETLEMASR VRQSLGNRAP CSSGGSHSHT IASATA
//
