ID A0A0S7Y9B5_9BACT Unreviewed; 180 AA.
AC A0A0S7Y9B5;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Signal peptidase I {ECO:0000256|RuleBase:RU362042};
DE EC=3.4.21.89 {ECO:0000256|RuleBase:RU362042};
GN ORFNames=AMJ50_02745 {ECO:0000313|EMBL:KPJ71254.1};
OS Parcubacteria bacterium DG_74_3.
OC Bacteria; Candidatus Parcubacteria.
OX NCBI_TaxID=1703767 {ECO:0000313|EMBL:KPJ71254.1, ECO:0000313|Proteomes:UP000051833};
RN [1] {ECO:0000313|EMBL:KPJ71254.1, ECO:0000313|Proteomes:UP000051833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG_74_3 {ECO:0000313|EMBL:KPJ71254.1};
RX PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT among widespread estuary sediment bacteria.";
RL Microbiome 3:14-14(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC from secreted and periplasmic proteins.; EC=3.4.21.89;
CC Evidence={ECO:0000256|RuleBase:RU362042};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362042}; Single-
CC pass type II membrane protein {ECO:0000256|RuleBase:RU362042}.
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|RuleBase:RU362042}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPJ71254.1}.
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DR EMBL; LJNG01000014; KPJ71254.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S7Y9B5; -.
DR STRING; 1703767.AMJ50_02745; -.
DR Proteomes; UP000051833; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019533; Peptidase_S26.
DR NCBIfam; TIGR02227; sigpep_I_bact; 1.
DR Pfam; PF10502; Peptidase_S26; 1.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU362042};
KW Protease {ECO:0000256|RuleBase:RU362042}.
FT DOMAIN 42..179
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT ACT_SITE 46
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 88
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 180 AA; 20444 MW; 448FAB398D256CED CRC64;
MFLIISGFLV FIFFFYFYLN KLDPSLENLN KECVIQTEKK IVQGNSLNGL IESGEVVEIL
FDYYNCNEVE REDVVLLNYP GFEKPIIKIV KGVSGDRFQL KETEQGWHVL INGNILQNSE
GIPYLLNEKR VGMLKLYEKD YRGIIPDNTL LLLGNLPSGS IDSTIFGLVD KSGILGKAIR
//
