ID A0A0S7YF69_9BACT Unreviewed; 232 AA.
AC A0A0S7YF69;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=AMJ48_01885 {ECO:0000313|EMBL:KPJ73302.1};
OS Parcubacteria bacterium DG_74_1.
OC Bacteria; Candidatus Parcubacteria.
OX NCBI_TaxID=1703765 {ECO:0000313|EMBL:KPJ73302.1, ECO:0000313|Proteomes:UP000051540};
RN [1] {ECO:0000313|EMBL:KPJ73302.1, ECO:0000313|Proteomes:UP000051540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG_74_1 {ECO:0000313|EMBL:KPJ73302.1};
RX PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT among widespread estuary sediment bacteria.";
RL Microbiome 3:14-14(2015).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPJ73302.1}.
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DR EMBL; LJNE01000005; KPJ73302.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S7YF69; -.
DR STRING; 1703765.AMJ48_01885; -.
DR PATRIC; fig|1703765.3.peg.358; -.
DR Proteomes; UP000051540; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 79..219
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 232 AA; 26826 MW; 6AA1605F21552966 CRC64;
MYITERQKTI LSSIVDEYIN SAQPVSSKFL EKKYDFGICP ASIRIEMQKL TDAGFLLQPH
TSAGRIPSDK GYRFFVDELL KKEMEGLELE DWFTGEIDGT IKFIQLLTKN LALASQSLAL
SYFEKEKIFW KEGWEEILRK PEFKEEDYII NFTELLASFE KNIEDLKLNS EIKVYIGREN
PFKKTKDFSI ISSKCCLPGD CQTIISLLGP KRMDYDRNIG LINSLTRLLS NT
//
