GenomeNet

Database: UniProt
Entry: A0A0S8D8C4_9PROT
LinkDB: A0A0S8D8C4_9PROT
Original site: A0A0S8D8C4_9PROT 
ID   A0A0S8D8C4_9PROT        Unreviewed;       316 AA.
AC   A0A0S8D8C4;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Homoserine kinase {ECO:0000256|HAMAP-Rule:MF_00301};
DE            Short=HK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            Short=HSK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            EC=2.7.1.39 {ECO:0000256|HAMAP-Rule:MF_00301};
GN   Name=thrB {ECO:0000256|HAMAP-Rule:MF_00301};
GN   ORFNames=AMJ66_06580 {ECO:0000313|EMBL:KPK32416.1};
OS   Betaproteobacteria bacterium SG8_40.
OC   Bacteria; Pseudomonadota; Betaproteobacteria.
OX   NCBI_TaxID=1703389 {ECO:0000313|EMBL:KPK32416.1, ECO:0000313|Proteomes:UP000051602};
RN   [1] {ECO:0000313|EMBL:KPK32416.1, ECO:0000313|Proteomes:UP000051602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG8_40 {ECO:0000313|EMBL:KPK32416.1};
RX   PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA   Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT   "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT   among widespread estuary sediment bacteria.";
RL   Microbiome 3:14-14(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC         Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC         EC=2.7.1.39; Evidence={ECO:0000256|HAMAP-Rule:MF_00301};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 4/5. {ECO:0000256|HAMAP-Rule:MF_00301}.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC       {ECO:0000256|ARBA:ARBA00038240, ECO:0000256|HAMAP-Rule:MF_00301}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPK32416.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LJTS01000094; KPK32416.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0S8D8C4; -.
DR   PATRIC; fig|1703389.3.peg.24; -.
DR   UniPathway; UPA00050; UER00064.
DR   Proteomes; UP000051602; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05153; HomoserineK_II; 1.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_II.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   NCBIfam; TIGR00938; thrB_alt; 1.
DR   PANTHER; PTHR21064:SF6; APH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605, ECO:0000256|HAMAP-
KW   Rule:MF_00301}; ATP-binding {ECO:0000256|HAMAP-Rule:MF_00301};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000313|EMBL:KPK32416.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00301};
KW   Threonine biosynthesis {ECO:0000256|ARBA:ARBA00022697, ECO:0000256|HAMAP-
KW   Rule:MF_00301};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000313|EMBL:KPK32416.1}.
FT   DOMAIN          27..251
FT                   /note="Aminoglycoside phosphotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF01636"
SQ   SEQUENCE   316 AA;  35228 MW;  A6A8E2D482A32343 CRC64;
     MSVFTTVTPE QARAWLRNYS IGSLVELKGI LSGIENTNYF LTTAHGRYVL TLFEKLTPNE
     LPFYLNLMAH LSNHGVPSPK PIANLQNEFL GELNGKPAAI VTCLPGQPVM DPGPDHCALV
     GEQLADMHLS GQSFKQHLDN LRCANWWTRV APEIYPFLSQ DDAQLLQSEI EFQAAVSREG
     LPRGPVHADL FRDNVLFDGD VVGGFIDFYF ACVDSLIYDV AITVNDWCAN PDATLDAERC
     EAMLGAYATV RSFTDQERAL WPAMLRAGAL RFWVSRLYDF HLPRPGELTH AHDPEPFRRL
     LQSHRNGGAD ASFLPG
//
DBGET integrated database retrieval system