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Database: UniProt
Entry: A0A0S8E199_9BACT
LinkDB: A0A0S8E199_9BACT
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ID   A0A0S8E199_9BACT        Unreviewed;       397 AA.
AC   A0A0S8E199;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   08-MAY-2019, entry version 18.
DE   RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   ORFNames=AMJ78_05970 {ECO:0000313|EMBL:KPK41259.1};
OS   Omnitrophica WOR_2 bacterium SM23_29.
OC   Bacteria; Candidatus Omnitrophica.
OX   NCBI_TaxID=1703776 {ECO:0000313|EMBL:KPK41259.1};
RN   [1] {ECO:0000313|EMBL:KPK41259.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM23_29 {ECO:0000313|EMBL:KPK41259.1};
RX   PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA   Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT   "Genomic resolution of linkages in carbon, nitrogen, and sulfur
RT   cycling among widespread estuary sediment bacteria.";
RL   Microbiome 3:14-14(2015).
CC   -!- FUNCTION: Participates in both transcription termination and
CC       antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC       dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPK41259.1}.
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DR   EMBL; LJUB01000057; KPK41259.1; -; Genomic_DNA.
DR   PATRIC; fig|1703776.3.peg.443; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1480.10; -; 1.
DR   Gene3D; 3.30.300.20; -; 2.
DR   HAMAP; MF_00945_B; NusA_B; 1.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR025249; KH_dom_NusA-like.
DR   InterPro; IPR009019; KH_sf_prok-type.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR030842; NusA_bac.
DR   InterPro; IPR036555; NusA_N_sf.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR013735; TF_NusA_N.
DR   InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR   PANTHER; PTHR22648; PTHR22648; 1.
DR   Pfam; PF13184; KH_5; 1.
DR   Pfam; PF08529; NusA_N; 2.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SMART; SM00322; KH; 2.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF47794; SSF47794; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF54814; SSF54814; 2.
DR   SUPFAM; SSF69705; SSF69705; 1.
DR   TIGRFAMs; TIGR01953; NusA; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945};
KW   RNA-binding {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription antitermination {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription termination {ECO:0000256|HAMAP-Rule:MF_00945}.
FT   DOMAIN      104    168       S1 motif. {ECO:0000259|PROSITE:PS50126}.
SQ   SEQUENCE   397 AA;  43602 MW;  A6C2779BA732658F CRC64;
     MNGELLTVLD HLEREKGIDR EVLMGAVESA LLSAAKKTLG SKAEDVSVKI DRKTGMIRVY
     SGKKEIPSDD FGRIAAQTAK QIIIQKIREA ERDVIYSDFL SRVGNVITGT VYRFEKGNIV
     VDLGKTEGII PRHGQSQKET FRQGDRIKAY VLEVKKTGKG PQITLSRSDP GLVRKLFDLE
     VPEIYEGIVE IKSISREAGD RTKLAVYSKD EKVDCVGACV GMRGSRVKNI VKELQSEKID
     IVRWSEDVKE YITAALNPAK VADIKLNKEQ KRALVIVDDD QLSLAIGKRG QNVRLAAKLT
     GWDIDIKSKS ALAEAEAAKP EEEKVPAKEK AKAKKEKDIG LIPGVGPKTK DALEAAKFKT
     VESIASASVE ELTKAKGIGK KTAEKILKGA KEILLEK
//
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