ID A0A0S8E3N4_9BACT Unreviewed; 168 AA.
AC A0A0S8E3N4;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 13-SEP-2023, entry version 20.
DE RecName: Full=HIT domain-containing protein {ECO:0000259|PROSITE:PS51084};
GN ORFNames=AMJ78_00115 {ECO:0000313|EMBL:KPK43011.1};
OS Omnitrophica WOR_2 bacterium SM23_29.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1703776 {ECO:0000313|EMBL:KPK43011.1, ECO:0000313|Proteomes:UP000050824};
RN [1] {ECO:0000313|EMBL:KPK43011.1, ECO:0000313|Proteomes:UP000050824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM23_29 {ECO:0000313|EMBL:KPK43011.1};
RX PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT among widespread estuary sediment bacteria.";
RL Microbiome 3:14-14(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPK43011.1}.
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DR EMBL; LJUB01000001; KPK43011.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S8E3N4; -.
DR Proteomes; UP000050824; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd01275; FHIT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR039383; FHIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR Pfam; PF01230; HIT; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 24..132
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 117..121
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 119
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT BINDING 49
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 121
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ SEQUENCE 168 AA; 19492 MW; 1BEFE9DE4B35B151 CRC64;
MDRIWAPWRI GYIKVTGKKQ TRCLFCHSLK SRKKNYVFLK NEYSFAMLNI FPYNNGHVMV
SPKRHIRDLQ SLTESEFTDM LKTLKQTLLL LDRVLKPQGY NVGMNIGKCS GAGIPGHLHL
HIVPRWEADT NFMPVVSNTK IISQSLDELY RELIAKAQKS DKSIKKKR
//
