ID A0A0S9RA50_9ACTN Unreviewed; 3044 AA.
AC A0A0S9RA50;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:KQP78974.1};
GN ORFNames=ASF37_10860 {ECO:0000313|EMBL:KQP78974.1};
OS Aeromicrobium sp. Leaf289.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=1736324 {ECO:0000313|EMBL:KQP78974.1, ECO:0000313|Proteomes:UP000051640};
RN [1] {ECO:0000313|Proteomes:UP000051640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf289 {ECO:0000313|Proteomes:UP000051640};
RA Garrido-Oter R., Mueller D.B.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000051640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf289 {ECO:0000313|Proteomes:UP000051640};
RA Vorholt J.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQP78974.1}.
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DR EMBL; LMNK01000002; KQP78974.1; -; Genomic_DNA.
DR RefSeq; WP_056580335.1; NZ_LMNK01000002.1.
DR Proteomes; UP000051640; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857}.
FT DOMAIN 2511..2962
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1169..1198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1729..1756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3044 AA; 317190 MW; D6A11758C640216C CRC64;
MTTTPTTPTT TSTATTGGRR EALVDRLRGG QRYAVVAGGQ GEAWLDALAT LVRDFALEAD
LTSVVDRAER TLEPVAGELL RTGATVTPLA WVDALAVGES AEDDEAPSLP SAVDQQVPAV
SVPGILLTQL AGLAALRRQG LDVTATPPVA SAGHSQGSLA LEALAGADPA ELYAYARLAG
AAAHVVGRRR GLLGATMLSV TGESPARVAE ALSTLPASAD VVTHLRNGRR SVVLSGPEEG
LRRAVTLMDE VAAAQKDERA RKVTGGAAFK PVVEPVAAQL AFHHPALSEA ADLAATWAAT
CGLDPEQART LTRRAVVEPV DWVAEVERVL DAGAEWLLDV GPGDLAARLS AAEAKVRGAG
VVSVATRRGH RELTVPGAAP RRSRPWSSYA PTAATLPDGS LRVETAFTRL TGRSPVLLAG
MTPTTVDAAI VAAAANAGYW AELAGGGQVS EQIFTERMAE LDDLLDEGRT FQFNSLFLDP
YLWKLQLGGQ RLVQKARAAG SPIDSVIVTA GIPELDEAVA LVEELAEVGI EYVVFKPGTV
AQIRQVLAIA DKVAPRSIIV QIEGGKAGGH HSWEDLDDLL VATYAQLRAH DNVVVCVGGG
IGTPEVAAAY LTGEWARAHG HPVMPLDGVL VGTAAMATLE ATTSPAVKQL LVDTPGTPAW
VGAGAADGGM SSGRSQLGAD IHEIDNTASR TGRLLDEVAG DADAVAARRD EIVEALDRTA
KPYFGDVATM TYGAWLDRFA ALTTDHAAPT GHDDEGGSAW LDVTLRDRFH AMLQRAEARL
VDVDHGPVAT LFATPADVED ATAALTALRE AHPAADDVVL HPADVPFFVQ VCRRPGKPVP
FVPVVDADVR RWWRSDSLWQ AHDPRFAADE VCVIPGTVSV AGITRVDEPV ADLLSRFEDA
AVDAVLASGA APLEVVGLRR ADGATGAVSL VLASPDAVWA GRAVRNPVHR LGTPASSSTG
WVSVAPERAE HPETGAVLTG SGHAAELVVP LDRGGRTLTL TFDVTDGVAT GGAPVISTST
AAAAMLDLLT AAAGGSLPSV SEGAATLSAP WSDDLAADHA GVTAGETAAF VPDALVGLAW
PAVFAVIGAS RTEAGDPVVE GMLDLVHLDH AIDVTRTPVD GTELTLRAAV RSVRATDLGR
VVTVDVTATD ADGTVATLVE RFCVRGRPGS ADAGEPVRAG GRLGDAEVHP TPRRTRAEGT
VVTPTDLRAF ASVSGDHNPI HTSVAAARLA GLGEPIAHGM WLSAAAQRVV ADATGRTLLG
WTTRWLSPLA PGAAVSVKAE RTALVDGDEV VEVTCRAGGE LVMAATARVA APRTAYAFPG
QGIQHPGMGM AGYQRSKAAR AVWDRADAHT RSALGFSILT VVRDNPTVLV AHGTTHKHPD
GVLFLTQFTQ VAMAVLGAAQ MAELRESGAF VEGSVLAGHS VGEYNALAAV SGVIPLEAVV
EVVFQRGSVM HTLVPRDEHG RSDYRLAAIR PSQIGLADDE VTAYVDGVAE RSGQFLQIVN
YNLRGSQYAI AGTVRGLEVL EEDIAERRAR FGGKAAFILV PGIDVPFHSR VLHGGVPDFR
ARLEELLPAE IDPTILEGRY VPNLVPRPFS LGQGFVQEIA DLVGESPLDA VLSDFDTWAA
RPQALCRTLL VELLAWQFAS PVRWIETQDL MFASVENGGL GVERFVEIGV GQSPTVANLA
SSTIRLPAVQ STLGERGVEV VNVERDAAAV FATDEDPAPI EDDVVDEAPA AESAATTAAP
APAAAPVSSG GPRPADLGFD AADGTRTLIA WWTKLRPEQI GAADSIESLC DGASSRRNQL
LVDLGGELSL GAIDGAADAD VPTLSAQVKG LARSYKPFGP VLSATFADHL KKVLGPTGRK
QSAVADRVTD VWQLGAGWAS HVLAELALST RDGASVRGGD LATIPVPSNG AEVDAAVDAA
VQAVAARHGV SVDLPSAGGS DATVDAAALA EITGEITGPD GVLASTARHL LAQLGLAADV
PSTETDEDAQ RVLDRVEAEL GSDWVDAVAP AFDERRAVLV DDRWASARED LARIALGQTA
PGGGSGPWAE KEIDLTGSGE VVASQARWWA GRTDDAALRA RLEQIAEAAL DTTPGTWSDD
VAVVTGASRG SIAASVVGEL LAGGATVVAT TSSLDSRKVG FYRELYRTHA RAGARLWVVP
ANMASFADVD ALSSWIVTEQ ARTVGSTKTV TKPALVPTLL VPFAAGRVMG DLSDAGSRTE
VEARILLWSV ERLVGALATT GRDHDLASRL HVLLPGSPNR GMFGGDGAYG EAKAALDAVV
TKWGAEKSWS DRVTLTHAII GWVRGTGLMG GNDPLVQAVE SAGVRTWSPD EMADALLTQG
CTTALREQAS VAPVELDLTG GLGEADLDLR ALAEGVERPT VEEDDETPTV AALAPSPAQL
PDAATPAWGE VTARPEDMVV IVGTGELGPY GSARTRFEME VHDELSAAGV LELAWNTGLI
MWDDVNQGWY DVESNEPVDE ADVHERYHDA VVARCGIRTY GDDGSMVDNT APLLTSVYLD
DDLTFSVGSE SEARAMVAAD PERTSITSSP DGEWTVTRKA GTEIRVPRRM ELSRTIGGQI
PTGFDPSAWG VPAEMLESID RVAIWNLVCT VDAFLSSGFT PAELMRWVHP AFVANTQGTG
MGGMASMHAL YINTLLGENN PNDILQEALP NVIAAHVVQS YVGSYGAMIH PVAACATTAV
SVEEGVDKIK VGKAEFVVAG GFDDLSTEGI IGFADMSATA DSGAMLAKGI DPRRVSRAND
RRRGGFVESQ GGGTLLLARG DVAARMGLPV HGVVAYAGSF ADGVHTSIPA PGIGALAAAI
GGRESQLARS LTVLGLDADD IGVVSKHDTS TDANDPNESE LHERLAAAIG RSAGNPLFVV
SQKTLTGHAK GGAAAFQLIG LTQVLAGGML PPNRSLDCVD DVLAEHEHLV WLREPLAGAT
LKAGLVTSLG FGHVAGLIAL AHPEAFVQAL PEAEREDYVA RSRERVVAGR MRLAQVMVGA
ATAYERPAGR RLGKEGVRGR EASVLLDPQA RLGDDDVYVA TACS
//