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Database: UniProt
Entry: A0A0T1SHR5_9ACTN
LinkDB: A0A0T1SHR5_9ACTN
Original site: A0A0T1SHR5_9ACTN 
ID   A0A0T1SHR5_9ACTN        Unreviewed;       588 AA.
AC   A0A0T1SHR5;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   05-JUN-2019, entry version 19.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   ORFNames=ASD33_08815 {ECO:0000313|EMBL:KQX53279.1};
OS   Streptomyces sp. Root1304.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1736450 {ECO:0000313|EMBL:KQX53279.1, ECO:0000313|Proteomes:UP000051136};
RN   [1] {ECO:0000313|Proteomes:UP000051136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root1304 {ECO:0000313|Proteomes:UP000051136};
RA   Garrido-Oter R., Bai Y.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQX53279.1, ECO:0000313|Proteomes:UP000051136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root1304 {ECO:0000313|EMBL:KQX53279.1,
RC   ECO:0000313|Proteomes:UP000051136};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KQX53279.1}.
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DR   EMBL; LMEP01000012; KQX53279.1; -; Genomic_DNA.
DR   RefSeq; WP_056560359.1; NZ_LMEP01000012.1.
DR   EnsemblBacteria; KQX53279; KQX53279; ASD33_08815.
DR   Proteomes; UP000051136; Unassembled WGS sequence.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR014276; 2-oxoglutarate_DH_E2.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 2.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 2.
DR   TIGRFAMs; TIGR02927; SucB_Actino; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 2.
DR   PROSITE; PS00189; LIPOYL; 2.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051136};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00065550};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051136};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:KQX53279.1}.
FT   DOMAIN        2     77       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      128    203       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      285    322       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
FT   REGION       96    125       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0T1SHR5}.
SQ   SEQUENCE   588 AA;  58603 MW;  A648DDF57E25DC30 CRC64;
     MSVSVTLPAL GESVTEGTVT RWLKAEGERV EADEPLLEVS TDKVDTEIPA PASGILASIK
     VAEDETVEVG AELAIIDDGT GAPAAAAPAA EAAPAPAAAP APAAEAPAAP APVAEAPAEA
     PAAGGATGTD VVLPALGESV TEGTVTRWLK SVGETVEADE PLLEVSTDKV DTEIPAPVSG
     VLLEIVVAED ESAEVGAKLA VIGAAGAAPA AAPAPAPVAP AAAPAPVAAP APVAPAAPVA
     APAPVAPAAP VAAPAPVAPA APSIAPALVT PVPAAPAAPA EDGAYVTPLV RKLATENGVD
     LAAVKGSGVG GRIRKQDVLA AAEAKKAAAA PAAAPAAAAK APALEVSPLR GQTVKMTRMR
     KVIGDNMMKA LHGQAQLTSV VEVDITKLMK LRAKAKDAFA AREGVKLSPM PFFVKAAAQA
     LKAHPVINAR INEDEGTITY FDTENIGIAV DSEKGLMTPV IKGAGDLNIA GISKKTAELA
     GAVRASKITP DDLAGATFTI SNTGSRGALF DTIIVPPNQV AILGIGATVR RPVVINHPDL
     GETIAIRDMT YVALSYDHRL VDGADAARYL TSVKAILEAG EFEVDLGL
//
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