ID   A0A0T2IE65_9MICO        Unreviewed;       592 AA.
AC   A0A0T2IE65;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:KQZ88984.1};
GN   ORFNames=ASD62_06350 {ECO:0000313|EMBL:KQZ88984.1};
OS   Phycicoccus sp. Root563.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC   Phycicoccus.
OX   NCBI_TaxID=1736562 {ECO:0000313|EMBL:KQZ88984.1, ECO:0000313|Proteomes:UP000051641};
RN   [1] {ECO:0000313|Proteomes:UP000051641}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root563 {ECO:0000313|Proteomes:UP000051641};
RA   Garrido-Oter R., Bai Y.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQZ88984.1, ECO:0000313|Proteomes:UP000051641}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root563 {ECO:0000313|EMBL:KQZ88984.1,
RC   ECO:0000313|Proteomes:UP000051641};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KQZ88984.1}.
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DR   EMBL; LMGM01000001; KQZ88984.1; -; Genomic_DNA.
DR   RefSeq; WP_056915237.1; NZ_LMGM01000001.1.
DR   AlphaFoldDB; A0A0T2IE65; -.
DR   STRING; 1736562.ASD62_06350; -.
DR   OrthoDB; 9771883at2; -.
DR   Proteomes; UP000051641; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 2.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000051641}.
FT   DOMAIN          7..185
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          188..284
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          314..492
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          495..591
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   592 AA;  63436 MW;  5F74775E4642D878 CRC64;
     MAREFSKVAV VGLGTMGAGI VEVFARNAID VVAIEVDEAA VDKGRGVLQH STDRAVSRGK
     LSVEDQADLH ARVHFTSSMD EVADCQLVIE AVPEHLHLKK EIFAKLDAVV GPDAILATNT
     SSLSVTEIAV ATSNPKRVVG MHFFNPAPVL QFVEVIRTVV TEDEVFEDVK ALAQRLGKQP
     VVVGDKAGFI ANALLFGYLN HAVAMFESRY ASREDIDAAM KLGCGYPMGP LALMDLIGLD
     TAYEILDTMY KQGRDRLHAP SPILKQMVSA GLKGRKSGRG FYTYAEPGSS QLVDDALSPA
     ADGGDHEATR TVRTVGVVGS GTMATGIIEV FAKAGFDVTY VTRSQPKVDA VTAAVQKSLE
     KAVQRGKLTQ EARDEALRHL TGSTSLDDLA TVDLVVEAVL EDLAVKRALF ENLDEICKPG
     AILATTTSSL PVVECAAATT RPQDVIGMHF FNPAQVMKLV EVVHTVSTAP DVVATVEQLC
     ADLDKHSVTC GDRSGFIVNA LLFPYLNDAV KMLEANYATA DAIDTAMKTG CGLPMGPFEL
     LDVVGLDVSL AIQRELYLEF RERGFAPAPL LEHLVTAGYL GRKSGRGFRT YA
//