ID A0A0T2Q8P5_9SPHN Unreviewed; 521 AA.
AC A0A0T2Q8P5;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KRA80594.1};
GN ORFNames=ASD76_15675 {ECO:0000313|EMBL:KRA80594.1};
OS Altererythrobacter sp. Root672.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Altererythrobacter.
OX NCBI_TaxID=1736584 {ECO:0000313|EMBL:KRA80594.1, ECO:0000313|Proteomes:UP000051125};
RN [1] {ECO:0000313|EMBL:KRA80594.1, ECO:0000313|Proteomes:UP000051125}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root672 {ECO:0000313|EMBL:KRA80594.1,
RC ECO:0000313|Proteomes:UP000051125};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KRA80594.1, ECO:0000313|Proteomes:UP000051125}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root672 {ECO:0000313|EMBL:KRA80594.1,
RC ECO:0000313|Proteomes:UP000051125};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRA80594.1}.
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DR EMBL; LMHH01000003; KRA80594.1; -; Genomic_DNA.
DR RefSeq; WP_055925236.1; NZ_LMHH01000003.1.
DR AlphaFoldDB; A0A0T2Q8P5; -.
DR STRING; 1736584.ASD76_15675; -.
DR OrthoDB; 7178350at2; -.
DR Proteomes; UP000051125; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000051125}.
FT ACT_SITE 88
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 22..25
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 88
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 343
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 352
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 356
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 521 AA; 59046 MW; 8D771AC7ED5B69C5 CRC64;
MTVSDSTTSE GREVERVVIV GGGTAGWMAA AALSRFLDNG RRQFHLVESE AIGTVGVGEA
TIPPILNFNR MLDINENEFL RETQGTIKLG IEFVNWGRIG DRYTHPFGFF GQELHGIAFH
QLWLREQGRG NPGYISDYCM SAVAAANGRF GRPSQNTKPP VSEMLYAFHF DASLYARYLR
GRAEKQGVRR HEGRIVQVHR DSELGDVRSV ELESGERIEG DLFIDCSGFR ALLIGETLGV
GYEDWSQWLP VDRAIPVPTT NIATPDPFTR ATAHSAGWQW RIPLQHRTGN GHVYCSAFMD
DDEAERILMA NLEGEPFADR RVIRFTTGRR KQSWSHNVIA LGLSSGFLEP LESTSIHLIQ
NGIQRLLALF PDRQISSIER DEYNRGMQDL YEDIRDFIIL HYKATQRDDT PFWRHVRDMA
VPETLTRKLE LWRLHGRVFR EGAELFGLTS WVAVLLGQNI WPDTYEPIVD TLDEAKVAVA
FKEMRERYYA AAMALPSQEE FLRMAGAWAA QDVRPQVAAA Q
//
