ID A0A0T5PDJ9_9RHOB Unreviewed; 575 AA.
AC A0A0T5PDJ9;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Acetolactate synthase isozyme 3 large subunit {ECO:0000313|EMBL:QEW25800.1};
DE EC=2.2.1.6 {ECO:0000313|EMBL:QEW25800.1};
GN Name=ilvI_1 {ECO:0000313|EMBL:QEW25800.1};
GN ORFNames=RIdsm_01589 {ECO:0000313|EMBL:QEW25800.1}, XM52_06155
GN {ECO:0000313|EMBL:KRS19229.1};
OS Roseovarius indicus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseovarius.
OX NCBI_TaxID=540747 {ECO:0000313|EMBL:KRS19229.1, ECO:0000313|Proteomes:UP000051401};
RN [1] {ECO:0000313|EMBL:KRS19229.1, ECO:0000313|Proteomes:UP000051401}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B108 {ECO:0000313|EMBL:KRS19229.1,
RC ECO:0000313|Proteomes:UP000051401};
RA Li G., Lai Q., Shao Z., Yan P.;
RT "The draft genome sequence of Roseovarius indicus B108T.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QEW25800.1, ECO:0000313|Proteomes:UP000325785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26383 {ECO:0000313|EMBL:QEW25800.1,
RC ECO:0000313|Proteomes:UP000325785};
RA Vollmers J., Petersen J.;
RT "Genetic Globetrotter - A new plasmid hitch-hiking vast phylogenetic and
RT geographic distances.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; LAXI01000002; KRS19229.1; -; Genomic_DNA.
DR EMBL; CP031598; QEW25800.1; -; Genomic_DNA.
DR RefSeq; WP_057814287.1; NZ_LAXI01000002.1.
DR AlphaFoldDB; A0A0T5PDJ9; -.
DR STRING; 540747.SAMN04488031_1033; -.
DR KEGG; rid:RIdsm_01589; -.
DR PATRIC; fig|540747.5.peg.2817; -.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000051401; Unassembled WGS sequence.
DR Proteomes; UP000325785; Chromosome.
DR GO; GO:0003984; F:acetolactate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd00568; TPP_enzymes; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR18968:SF13; ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000051401};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:QEW25800.1}.
FT DOMAIN 13..117
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 214..349
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 405..550
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 575 AA; 59977 MW; CF513DBEDF824A10 CRC64;
MTCQPLYDAP VAAADAIVDT LIAAGIKHVF GLSGGHTGRI FGALEKRQEK IRTILVREES
LGAVMAETIG RITGAPSVLL GQGPWVLGNG LLGTIEAHLS ATPLLLLTDF SDTPGASLHA
PYQSGTGEYG NWDARQAFGA VTKEVFTAED PNSAVVATQL AIKHACSGEP GPVAMLLGLR
ALDGEARPEA APRIYPAEAF IAPPLRGVPE LTASLAALQG AARPLIIAGN GIRVGRAEAA
LMRFAEACGI PVVTSPSGKG VFDEDHVLSC GVYGGYGNPL AHRAVAGADV ILAIGTKLSA
SDTNNGDTGL IDPSRQTLIQ VDIEPRNLSW TIPVAHPLLG DAATILDALR TGWTAAAHET
WTAALNTPRH VSLPASDAGA AAIHPHEIIA TMQEILPRET IYTCDAGENR IFMLHFLRPR
GAGRFIQPAG AGPMGYALPS AMARKLLSPE NPVVAFSGDG GFSMTMNGLI TAIEAALPII
SVVMNNDALG WSQHSRGPFA TQFSRVDYAA IARGMGCAGF HASGIEPLKE ALAAALRVTQ
EEQRPAVIDV EASMEVSFAR LAYSETSETR GLAAD
//
